Ask about this productRelated genes to: VASP antibody
- Gene:
- VASP NIH gene
- Name:
- vasodilator stimulated phosphoprotein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-07
- Date modifiied:
- 2017-06-13
Related products to: VASP antibody
Related articles to: VASP antibody
- Atomic charge descriptors are widely used to interpret chemical bonding, quantify charge transfer, and construct data-driven models for inorganic materials. This data article describes a first-principles dataset containing Hirshfeld and iterative-Hirshfeld outputs for 5080 inorganic materials, corresponding to 31,288 atomic sites and 77 chemical elements. For each material, the database stores the atomic structure, Materials Project identifier, calculation metadata, standard Hirshfeld charges, iterative Hirshfeld charges, Hirshfeld relative volumes, and iterative-Hirshfeld relative volumes. The data were generated using density-functional theory calculations in VASP with a consistent local-density-approximation setup, a 500 eV plane-wave cutoff, 0.25 inverse angstrom k-point spacing, and an electronic convergence threshold of 1e-6 eV. The dataset is distributed as an ASE database with accompanying JSON statistics, analysis scripts, figures, and a Flask-based web interface. It can support charge-transfer analysis, benchmarking of charge-partitioning methods, and charge-informed machine-learning workflows in which atomic populations, charge-transfer magnitudes, or volume descriptors are used as features for materials-property prediction. - Source: PubMed
Publication date: 2026/09/04
Su TianhaoLi MusenWang XitaoHu ShunboZhang Tong-Yi - Chemoresistance remains a major obstacle limiting the therapeutic efficacy of gastric cancer treatments, and cytoskeleton remodeling together with the abnormal membrane localization of drug efflux proteins may contribute to resistance phenotypes. This study aimed to investigate the role of CD44v6 in gastric cancer chemoresistance and to clarify whether betulonic acid, an active monomeric component of Celastrus orbiculatus extract, can reverse drug resistance via CD44v6. Analysis of public databases and validation in clinical tissue samples revealed that CD44v6 was highly expressed in gastric cancer cells and associated with poor prognosis, whereas CD44v6 expression was positively regulated by polypyrimidine tract binding protein 1. CD44v6 expression was markedly upregulated in MKN-45/DDP and HGC-27/Oxaliplatin resistant cells. CD44v6 knockdown inhibited GC cell proliferation, colony formation, migration/invasion, and tumor growth and increased the sensitivity of resistant cells to DDP or oxaliplatin. Mechanistically, CD44v6 knockdown suppressed F-actin remodeling, pseudopodia formation, cell motility, and the phosphorylation of VASP, Ezrin/Radixin/Moesin and Cofilin. Multiplex immunofluorescence analysis of tissue microarrays, molecular docking, and coimmunoprecipitation confirmed that CD44v6 was coexpressed and interacted with Ezrin/Radixin/Moesin family proteins in gastric cancer tissues. Betulonic acid was identified as a candidate active monomer of Celastrus orbiculatus extract that could potentially bind to CD44v6. Treatment with betulonic acid inhibited the malignant biological behaviors of gastric cancer cells, increased chemosensitivity, reduced membrane-associated P-glycoprotein expression, and weakened the interaction between CD44v6 and ERM proteins. In MKN-45/DDP xenograft models, betulonic acid combined with DDP significantly inhibited tumor growth and partially alleviated DDP-associated toxicity. In conclusion, CD44v6 promotes gastric cancer chemoresistance by interacting with Ezrin/Radixin/Moesin proteins to regulate cytoskeleton remodeling and membrane-associated P-glycoprotein expression, whereas betulonic acid reverses DDP resistance by through the CD44v6-ERM axis. This study provides mechanistic evidence supporting betulonic acid as a potential chemosensitizer for gastric cancer treatment. - Source: PubMed
Publication date: 2026/09/12
Chu ZewenZhu MiaoLuo YuanyuanTu XiaominLi XiangWang HaiboLiu YanqingFang LeiDing YueXiang Yanwei - Cell migration frequently employs protrusions termed lamellipodia, constituting the prime model system for generation of branched actin filament networks. Here we utilize genome editing to explore the functional connections between the actin monomer-binding protein profilin (Pfn), the filament nucleating Arp2/3 complex, its co-factor heterodimeric capping protein (CP) and Ena/VASP family polymerases in lamellipodial actin assembly. We show that Pfn counters Ena/VASP but promotes Arp2/3 complex activity, while Ena/VASP and CP mutually antagonize each other. While Pfn promotes Arp2/3 complex activity irrespective of Ena/VASP, sensitivity of CP to Pfn removal vanishes in the absence of Ena/VASP. Our findings establish Pfn as master regulator of Arp2/3 complex-dependent actin network formation, differentially regulating VASP and its antagonizer CP. Mathematical modeling of our data suggest Ena/VASP and CP to compete for recruitment to lamellipodial edges. Our work provides critical insights into the molecular logic of branched actin network assembly in protrusion and force generation. - Source: PubMed
Publication date: 2026/09/16
Tang YuboSchaks MatthiasJiang XinqiKarger MariusMietkowska MagdalenaKaltenhäuser JulianScholz JonasBenavente-Naranjo RuthHu SijianKörber SarahLi ZhilunLambert ChristopherHenty-Ridilla Jessica LStradal Theresia E BKarlsson RogerBieling PeterFaix JanFalcke MartinRottner Klemens - Zirconia is a technologically relevant material widely employed in catalysis owing to its thermal stability, acid-base surface properties, and optical response, enabling applications both as a solid acid catalyst and as a photocatalytic material. Even so, the relatively low specific surface area of bulk zirconia may limit its catalytic performance, making supported systems and mixed oxides attractive alternatives for enhancing dispersion and surface accessibility. Among these, zirconia-alumina mixed oxides have attracted significant attention because of the strong interfacial interactions established between both phases, which may involve a migration of Zr⁺ species into the subsurface region of alumina, leading to the formation of structurally stable mixed oxide domains. This behavior has been associated with modifications in the electronic structure and surface reactivity of the material. In the present work, the UV absorption spectrum of the mixed oxide was calculated, and reasonable agreement was achieved with the measured gap and spectrum, reinforcing the existence of the mixed oxide. The bandgap was determined as 6.47 eV, close to the experimental values, and the simulated spectrum shows good agreement with the experimental profile. - Source: PubMed
Publication date: 2026/09/09
Rocha Alexandre BRocha Angela S - Mg-Li alloys are among the lightest structural materials and exhibit excellent ductility, but their relatively low strength limits broader applications. Alloying, such as with Al, is an effective approach for strengthening Mg-Li alloys. However, the dislocation behavior in BCC Mg-Li alloys remains poorly understood. In this study, we first developed a highly accurate machine-learning potential (MLP) for Mg-Li-Al alloys. The developed MLP was subsequently applied to investigate the dislocation behavior of three representative alloys, Mg-38Li, Mg-38Li-2Al, and Mg-38Li-4Al (a.t.%). The results show that both alloys exhibit split screw dislocation core structures. Al addition is associated with more tortuous, intermittent edge dislocation motion and lower edge dislocation mobility. It also reduces screw dislocation velocity, although the reduction is smaller than that for edge dislocations. Screw dislocations are substantially less mobile than edge dislocations over the investigated stress range. The simulations further indicate that kink-pair activity on multiple planes and the resulting cross-kink configurations may contribute to the low screw dislocation mobility. These findings provide atomistic evidence for how minor Al additions modify dislocation motion in the modeled BCC Mg-Li alloys. - Source: PubMed
Publication date: 2026/09/08
Yao YiLiu GuoqiangMa YangzhouSong Guangsheng