Ask about this productRelated genes to: VASP antibody
- Gene:
- VASP NIH gene
- Name:
- vasodilator stimulated phosphoprotein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-07
- Date modifiied:
- 2017-06-13
Related products to: VASP antibody
Related articles to: VASP antibody
- Aberrant platelet activation is a major contributor to thrombotic disorders, prompting interest in naturally derived candidates that can safely regulate platelet function. Sappanchalcone, a chalcone-type flavonoid derived from L, has diverse biological activities; however, its effects on platelet activation and clot retraction remain unclear. This study evaluated the antiplatelet potential of sappanchalcone and its underlying mechanisms in human platelets. - Source: PubMed
Lee Ga HeeLee Jin PyoPark Chang EunLee Dong-Ha - Quantum dots (QDs) have been explored as active elements of scintillators, dosimeters and detectors for X-ray and gamma-ray ionizing radiation. This integrative review catalogued the computational simulation tools used in QD-detector studies published between 2018 and 2026, reporting the empirical evidence of use for each tool and the limitations declared by the original authors. Following Whittemore and Knafl's method combined with PRISMA-ScR reporting elements, five databases were queried (Scopus, Web of Science, PubMed, IEEE Xplore, and Google Scholar via Publish or Perish). The search yielded 4530 unique records after de-duplication, from which 35 studies were extracted through a structured form (30 fields): 34 published within the window plus one pre-window historical reference. The inventory distinguished two complementary classes: (A) twenty-four codes that model the QD itself (Table 5A), spanning ab initio, tight-binding, quantum transport and open-quantum-systems methods; and (B) fourteen Monte Carlo radiation-transport codes (Table 5B), namely Geant4, GATE 10, TOPAS, EGSnrc, PENELOPE, CASINO, FLUKA, MCNP/MCNPX, PHITS, TOPAS-nBio, Geant4-DNA, SSLG4, Chroma and optiGAN. Across the 35 studies, Geant4 was the most frequently declared radiation-transport engine (six studies). In the broader QD-modelling literature, VASP, Quantum ESPRESSO and DFTB + concentrated the atomistic parametrisation of II-VI and perovskite QDs. Each study declared between one and three tools, and explicit integration between radiation-transport engines and QD electronic-structure codes remained uncommon in the analysed literature. The consolidated inventory was intended as a reference for the QD-detector research community. - Source: PubMed
Publication date: 2026/09/01
Silva Paulo José IackAlves Cristiano da CostaBarbosa Nilseia AparecidaAraújo-Moreira Fernando M - Defining quantitative biochemical mechanisms of microtubule dynamics and regulation is a current challenge. Stu2/XMAP215-family polymerases use tubulin-binding TOG domains to catalyze microtubule growth, but how polymerase activity results from the number and tubulin-binding properties of TOGs is not understood. We tested whether an enzyme-like biochemical model for the unrelated actin polymerase Ena/VASP could be applied to quantitatively relate Stu2 microtubule polymerase activity to the number of its TOGs, and the rate constants governing their interactions with tubulin. Stu2 activity displayed enzyme-like characteristics consistent with the biochemical model: Stu2 stimulated microtubule growth rates with hyperbolic dependence on tubulin concentration, and the amount of Stu2 on the microtubule end did not vary with tubulin concentration (microtubule growth rate). Complementary measurements of TOG:tubulin binding revealed high affinity (10 nM) and slow dissociation (0.03 s). The polymerase and binding measurements can be unified within the biochemical model: Stu2 operates with high efficiency, acting as a tubulin-shuttling antenna on the microtubule end that is primarily limited by the rate of tubulin:TOG association. Our work thus provides a quantitative biochemical mechanism for TOG-based polymerases. That unrelated microtubule and actin polymerases use the same enzyme-like mechanism provides an example of convergent evolution in the cytoskeleton. - Source: PubMed
Publication date: 2026/09/03
Gangadharan BinnuKober Daniel LRice Luke M - Inorganic halide perovskite RbSrI3 has recently attracted attention as a lead-free material for radiation detection and optoelectronic applications. However, most theoretical studies have assumed an ideal cubic structure as the ground-state phase, despite the strong tendency of halide perovskites toward polymorphism and experimental evidence for an orthorhombic structure. Here, we resolve this discrepancy through a comprehensive first-principles density functional theory (DFT) investigation using the GGA-PBE functional and the projector augmented-wave method as implemented in VASP. The HSE06 hybrid functional was additionally employed to validate the calculated electronic band gaps. Energetic, dynamical, and finite-temperature thermodynamic analyses consistently identify the distorted orthorhombic Cmcm phase as the true ground state, while the cubic phase is dynamically unstable. Importantly, we show that energetic ordering alone is insufficient to establish the proper ground state, since lattice-dynamical stability is essential for distinguishing a true minimum from an unstable or saddle-point structure. The instability of the high-symmetry phase is traced to an A-site-driven lattice mismatch, in which the undersized Rb+ cation gives rise to soft Rb-I vibrational modes that drive cooperative octahedral rotations. Crystal orbital Hamilton population analysis further shows that octahedral tilting strengthens Rb-I interactions while reducing antibonding Sr-I contributions, thereby stabilizing the distorted structure. Octahedral tilting also modifies the optoelectronic response, increasing the GGA-PBE band gap from 3.32 eV in cubic Pm-3m to 3.76 eV in orthorhombic Cmcm phase. Higher-level HSE06 calculations confirm this trend, giving corresponding band gaps of 4.34 and 4.77 eV, respectively. The structural distortion also modifies the optical spectra significantly. These results establish the correct structural reference for RbSrI3 and provide a microscopic framework linking geometric mismatch, lattice dynamics, chemical bonding, and optoelectronic behavior in lead-free halide perovskites. - Source: PubMed
Publication date: 2026/09/02
Majumder RinkuMondol ChandrikaChakraborty ArponHossain Md RakibChakrobortty AyonMina Md SalahuddinBiswas AnujoyHakim S M Jayed - Neuronal programmed cell death, inflammation, and blood-brain barrier (BBB) disruption drive secondary injury after subarachnoid hemorrhage (SAH). However, no multi-target therapies are currently available. Banxia Baizhu Tianma Decoction (BBTD) shows therapeutic potential for cerebral hemorrhage. This study aimed to investigate BBTD's protective mechanisms against these pathologies post-SAH. - Source: PubMed
Publication date: 2026/08/26
Wang WeiqiGuo NingZhou GuoqingZhang WanjingXu TongtongZhao JiaLiu LuHou Yajun