Ask about this productRelated genes to: JAK2 antibody
- Gene:
- JAK2 NIH gene
- Name:
- Janus kinase 2
- Previous symbol:
- -
- Synonyms:
- JTK10
- Chromosome:
- 9p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-16
- Date modifiied:
- 2019-04-23
Related products to: JAK2 antibody
Related articles to: JAK2 antibody
- Large cell lung carcinoma (LCLC) is an aggressive non-small cell lung cancer subtype. Mulberrofuran G (MG) from L. possesses pharmacological properties, but its anticancer mechanisms in LCLC remain unexplored. This study aimed to validate the antitumor activity of MG against NCI-H460 cells and elucidate its dual mechanism involving Janus kinase 2 (JAK2) inhibition and reactive oxygen species (ROS) induction. - Source: PubMed
Publication date: 2026/08/01
Li Zhong-RuiZheng YuHan ChaoWang Lei - Psoriasis is a chronic immune-mediated skin disease characterized by strong genetic susceptibility and autoimmune components. Identifying lead compounds from natural products for psoriasis has been proposed as a promising therapeutic strategy. Citri Reticulatae Pericarpium (CRP) is a traditional Chinese medicine material rich in polymethoxy flavonoids with anti-inflammatory, antioxidant, and immunomodulatory activities. Whereas, the bioactive constituents of CRP responsible for anti-psoriatic effects and its underlying mechanism have yet to be elucidated. In this study, we employed network pharmacology analysis to pinpoint tangeretin (Tan) as the major anti-psoriatic component of CRP, and further systematically evaluated its anti-psoriatic effects and investigated its underlying mechanisms. Tan significantly attenuated IMQ-induced psoriasiform skin lesions in mice, as evidenced by the remarkably decrease in erythema, scaling, skin thickness, inflammatory cell infiltration, and several inflammatory factors. Further mechanism revealed that Tan inhibited the binding of IL-23 to the IL-23 receptor, and suppressed downstream JAK2/STAT3 and MAPK activation, thereby reducing inflammation and attenuating psoriasis progression. Overall, these findings provide strong evidence for Tan represents to be developed into a therapeutic candidate for psoriasis management. Our study also provides a scientific rationale for the therapeutic application of CRP against psoriasis. - Source: PubMed
Publication date: 2026/09/19
Liu QingLiu JingWang ZirenZheng YihangLi YujuanHuang JianhuaJiang YachaoLei XiaoyongWang Junjie - Philadelphia-negative myeloproliferative neoplasms comprise a rare and biologically heterogeneous spectrum of hematopoietic stem cell malignancies. According to established clinicopathological criteria, these entities are principally categorized as polycythemia vera, essential thrombocythemia, or primary myelofibrosis. Ophthalmic manifestations are common in hematological diseases, yet they remain under-researched in this patient population. - Source: PubMed
Publication date: 2026/09/18
Piloni-Parreira RômuloBarbosa Melaine StefaneNeves Laís LauriaSantana Hernani LopesRodrigues João Marcos Ranyere da SilvaTavares Renato SampaioIsaac David Leonardo CruvinelPereira de Ávila Marcos - Bladder cancer (BCa) is one of the most common urological malignancies, with a steadily increasing global incidence. Pyrroline-5-carboxylate reductase 1 (PYCR1) is a metabolic regulator with noncanonical oncogenic functions; however, its protein interaction network and downstream mechanisms in BCa remain incompletely understood. - Source: PubMed
Chen HaotianJi ShuyaWu PengfeiLiu JiZhang WentaoGuo YadongZhang JingchengZhang ZhijingLiu YanLingLiu YongqiangJin ChengqiDi SichenWu YangZhang JunfengZhu XiaojunMao ShiyuShen BingYao Xudong - An 82-year-old woman with JAK2-mutated myelofibrosis who developed hemoptysis after initiation of ruxolitinib. She presented with anemia and ground-glass opacities and was treated with antibiotics. She was readmitted with worsening respiratory symptoms. Sputum cultures yielded . Her clinical course was complicated by leukocytosis with blasts prior to death. - Source: PubMed
Publication date: 2026/09/16
Sekiya MataichiYekuno KalkidanGhumare IshanMargulis Marina