Ask about this productRelated genes to: VEGFR2 antibody
- Gene:
- KDR NIH gene
- Name:
- kinase insert domain receptor
- Previous symbol:
- -
- Synonyms:
- FLK1, VEGFR, VEGFR2, CD309
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2019-04-23
Related products to: VEGFR2 antibody
Related articles to: VEGFR2 antibody
- Following the common structural features of VEGFR-2, EGFR, and HER-2 kinase inhibitors, two newly synthesized series of 3,4-dihydropyrimidine 2(1H)-(thio)ones-5-carboxamide (2a-l) and thiouracil-5-sulfonyl derivatives (4a-e) were evaluated for anti-proliferative activity against colorectal (HCT-116) and breast (MCF-7) cancer cell lines. Among the designed series, Compounds 2h and 2l were the most potent derivatives across both tumor models, exhibiting IC values of 23.3 and 30.9 μM (HCT-116), respectively, and 31.5 and 39.2 μM (MCF-7), respectively, compared to sorafenib (IC = 8.8 and 11.6 μM, respectively). Interestingly, 2h and 2l displayed a favorable safety profile toward the normal human cell line WI-38, with IC > 200 μM comparable to sorafenib (IC = 192 μM). In vitro enzymatic assays, 2h and 2l derivatives emerged as potent multi-kinase inhibitors targeting VEGFR-2, EGFR, and HER-2 with IC = 0.20, 0.21, and 0.19 μM, respectively, and IC = 0.67, 0.53, and 0.40 μM, respectively, hence circumventing cancer resistance mechanisms. The most potent Compound 2h prompted apoptosis and necrosis at % G0-G1 phase in HCT-116 via the activation of caspase-3 and 8, with significant downregulation of anti-apoptotic protein Bcl-2. Additionally, Compound 2h markedly suppressed immunomodulatory proteins TNF-α and IL-6 levels by 80.9% and 88.2%, respectively, in comparison to dexamethasone (82.7% and 93.2%, respectively), which attenuates tumor-promoting inflammation, disrupting pro-survival signaling pathways and metastasis. In silico ADMET, toxicity, and molecular docking studies were performed; notably, the docking simulations generated an interesting hypothesis for potential direct binding to Bcl-2, an effect distinct from the experimentally observed downstream downregulation of its expression. The present results pave the way for further developing of 2h candidate as a multi-tyrosine kinases inhibitor toward colon cancer cells. - Source: PubMed
Ahmed Naglaa MGaballah Mohamed SAltava BelenLotfallah Ahmed H - Cognitive impairment is a common symptom for these people entering high altitude. Unfortunately, the potential molecular mechanisms are not totally clear. This study aimed to identify the genes and signaling pathways associated with high-altitude cognitive dysfunction (HACD) in mice. - Source: PubMed
Publication date: 2026/04/23
Xin YuYang ChenyuWang GegeMa HuipingJing Linlin - Pyrethroid resistance in Anopheles gambiae s.l. compromises malaria vector control in sub-Saharan Africa. In Benin, resistance has been documented for over two decades, but the geographic distribution of emerging mutations such as N1575Y remains poorly characterized. This study investigated pyrethroid susceptibility, kdr mutations, and metabolic resistance mechanisms across twelve communes spanning a south-north transect of the country. - Source: PubMed
Publication date: 2026/05/10
Ossé Razaki AHougbe Steve ZinsouAhouandjinou Minassou JuvenalSidick AboubacarAffolabi Zul-KiflKoumodji Koffi DjigbodiTokponnon FilémonAikpon RockSovi ArthurOrou Haziz A SinaBaba-Moussa LamineAkogbeto Martin - Gliosarcoma of the central nervous system (CNS) is a rare and aggressive neoplasm exhibiting biphasic differentiation into glial and mesenchymal components. We report a primary gliosarcoma with mesenchymal differentiation resembling follicular dendritic cell sarcoma (FDCS). A 72-year-old man presented with a rim-enhancing lesion in the left frontotemporal parenchyma. Histologically, the tumor was biphasic, comprising a glioblastoma (GBM) component of diffusely infiltrative GFAP- and Olig2-positive oligodendroglial-like cells with microvascular proliferation, and an FDCS component composed of cohesive sheets, nests, and fascicles of CD21-, CD23-, and CD35-positive plump spindle cells. NGS analysis performed on the microdissected components revealed shared PTEN p.N48S mutations with high variant allele frequencies and MGMT promoter methylation, suggesting a monoclonal origin. Furthermore, the two components exhibited divergent genetic profiles: the glial component was characterized by an FGFR1 mutation, PDGFRA fusion, KIT/KDR amplification, and a whole-arm 1p/19q codeletion, whereas the sarcomatous component harbored an ERBB4 p.S853F mutation. These alterations predominantly converged on the RAS-MAPK and PI3K-AKT-mTOR signaling pathways. No IDH1/2 mutations, EGFR gene amplification, or TERT promoter mutations were detected in either component. This case represents the first documented instance of primary gliosarcoma with FDCS differentiation, thereby expanding its known differentiation spectrum. Furthermore, it demonstrates the necessity of separately analyzing each histological component in the diagnosis of challenging cases. - Source: PubMed
Zhou JingZhao ShaLi HaiYang ShudongPan Minhong - is the primary vector of major arboviral diseases such as dengue fever, chikungunya fever, and Zika virus disease, and its control is highly dependent on chemical insecticides. However, the long-term use of pyrethroid insecticides has led to the development of insecticide resistance in , which severely undermines the efficacy of vector control programs. - Source: PubMed
Publication date: 2026/04/22
Liu LifangLiang GuoruiGao HetingXing SiyuWang KaiZhou XinyuHuang XinanLi Chunxiao