Ask about this productRelated genes to: VEGFR2 antibody
- Gene:
- KDR NIH gene
- Name:
- kinase insert domain receptor
- Previous symbol:
- -
- Synonyms:
- FLK1, VEGFR, VEGFR2, CD309
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2019-04-23
Related products to: VEGFR2 antibody
Related articles to: VEGFR2 antibody
- During a mosquito resistance survey, the emerging vector Culex perexiguus was detected for the first time in different locations in Sardinia (Italy), where Culex pipiens and Aedes albopictus constitute the majority of the local mosquito community. According to preliminary phylogenetic analysis based on cytochrome c oxidase subunit I (COI) gene sequences, Cx. perexiguus specimens from Sardinia clustered with specimens from other Mediterranean populations. However, the limited resolution of the short COI fragment precludes robust inference regarding their geographic origin, dispersal routes, or colonization history. Due to the potential implications for virus transmission and the consequent importance of Cx. perexiguus population management, investigations were conducted to evaluate the applicability of resistance detection methods commonly used for other Culex species to this species. Analysis of the voltage-gated sodium channel (vgsc) gene, the primary target site of pyrethroid insecticides, revealed notable sequence differences in Cx. perexiguus compared with other Culex species. Consequently, existing PCR-based assays developed for the Cx. pipiens complex to detect knockdown resistance (kdr) mutations, were adapted and validated for use in Cx. perexiguus in surveillance programs. - Source: PubMed
Publication date: 2026/08/27
Vinci AlessiaFoxi CiprianoDedola DanieleSini ValentinaSatta GiuseppeRuiu Luca - Cardiac angiosarcoma is a rare, highly aggressive malignancy arising from endothelial cells of the heart and accounts for ∼30% of primary cardiac tumors. Understanding its epidemiology and factors influencing mortality is critical, and emerging genomic data may inform personalized management. - Source: PubMed
Publication date: 2026/08/27
Ullah AsadWali AghaBansal Puneet KFadhil NooranSohail Amir HumzaCheedella Naga K SucharitaNadeem Muhammad AhmadJain HritvikIqbal AsifKhan MarjanKhan Rozi - This study aimed to monitor the resistance status of adult () to commonly used insecticides in Jining (Shandong Province), Guangzhou (Guangdong Province), and Haikou (Hainan Province), and to provide evidence for improving vector control strategies. - Source: PubMed
Publication date: 2026/08/12
Xu NuoPan XiaoPeng KunYin HaoYang YingchunHan ChenxinGong MaoqingLiu Hongmei - Angiosarcoma is a poorly understood sarcoma due to its high heterogeneity and rarity. Here we show a comprehensive clinical and molecular analysis of a large cohort of 254 angiosarcoma patients through the patient-partnered Angiosarcoma Project. By integrating transcriptomic, somatic, and germline variant data, we find that subcutaneous angiosarcomas frequently exhibit TGF-β and receptor tyrosine kinase signaling upregulation, with driver mutations in KDR, PLCG1, and POT1. Meanwhile, cutaneous angiosarcomas are enriched for MYC-driven programs, UV mutational signatures, immune checkpoint gene expression, and TP53, FLT4, and BRAF mutations. Germline POT1 pathogenic variant carriers have a 92.7-fold higher risk of developing angiosarcoma, with 'double-hit' germline and somatic variant carriers developing disease decades earlier. Additionally, POT1-mutated tumors underexpress TERT and overexpress CHAMP1. Altogether, these findings elucidate the molecular framework of angiosarcoma, nominate therapeutic targets, and highlight the power of direct patient engagement in rare cancers. - Source: PubMed
Publication date: 2026/07/24
Chu HoyinHollyer MarissaBorden Brittany AReilly Christopher RGómez Tejeda Zañudo JorgeThomas Beena SPhelps KolbePimenta Erica MariaHan SeunghunCamp Sabrina YGillani RiazGutierrez JacobLareau Caleb ANagy MatthewJohnson JeremyAlao OyinGrundman HadleySterlin LaurenTerzi WillSosa DeliaSmall Ilan KMcGillicuddy MaryAlharbi NoufAnastasio ElanaChastain ParkerBhakhri PriyankaHornick Jason LChoudhry HaniDiehl Diane MVan Allen Eliezer MWagle NikhilPainter Corrie AAlDubayan Saud - Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is a common female malignancy. Gut microbiota and metabolites are critical regulators of tumor immunity and therapy, but their roles in CESC remain unclear. This study integrated TCGA and GEO datasets with gut microbiota information to construct a protein-protein interaction network. These targets were prioritized using machine learning, SHAP interpretation, and Mendelian randomization analysis. Immune-related pathways were explored using single-cell and spatial transcriptomic analyses. Molecular docking and molecular dynamics simulations were performed to evaluate potential interactions between key metabolites and their targets. A total of 136 gut microbiota-related DEGs were identified, which may be associated with intercellular immune interactions. KDR was selected as a core target and may exert protective effects. Single-cell and spatial transcriptomic analyses suggested that specific metabolites may be associated with changes in the tumor microenvironment potentially involving the MIF signaling pathway. Network analysis of microbes, metabolites, and targets suggested that metabolites such as 5-(3,4-dihydroxyphenyl) pentanoic acid may serve as key mediators linking gut microbiota and KDR signaling. Additionally, eight non-toxic metabolites with favorable drug-likeness were identified, molecular docking and molecular dynamics simulation demonstrated stable binding to KDR with potential bioactivity, providing a theoretical basis for developing microbiota-related therapeutic strategies. The gut microbiota and its metabolites may be associated with the immune microenvironment and tumor progression in CESC, potentially involving the MIF signaling axis. This study provides a computational framework and preliminary evidence supporting microbiota-related hypotheses, and may inform future experimental investigations and therapeutic strategy development. - Source: PubMed
Publication date: 2026/08/25
Chen BinXu Changchang