Ask about this productRelated genes to: STAT6 antibody
- Gene:
- STAT6 NIH gene
- Name:
- signal transducer and activator of transcription 6
- Previous symbol:
- -
- Synonyms:
- D12S1644, IL-4-STAT
- Chromosome:
- 12q13
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-09
- Date modifiied:
- 2019-04-23
Related products to: STAT6 antibody
Related articles to: STAT6 antibody
- Solitary fibrous tumors of the pleura (SFTPs) are rare mesenchymal neoplasms that are usually benign but may occasionally recur or undergo malignant transformation. Tumor size is an important prognostic factor; lesions larger than 10 cm are associated with recurrence and poor outcomes, and tumor size ≥15 cm is considered as a risk factor in prognostic models. Histologically, benign SFTPs of ≥15 cm in size are extremely uncommon. - Source: PubMed
Publication date: 2026/04/28
Ichikawa YukiYokota KeisukeIguchi KensukeHosokawa ShinHagui EmiChiba KensukeNakamura RyujiTatematsu TsutomuOkuda Katsuhiro - : Solitary fibrous tumors are uncommon fibroblastic neoplasms. These tumors are characterized by the recurrent NAB2-STAT6 gene fusion, which is a hallmark of solitary fibrous tumors (SFTs), particularly those arising in the thoracic cavity. While SFTs are mostly found in the abdomen and pleura, they can occur in various locations, including the head and neck region (6% of cases of SFTs). Solitary fibrous tumors of the thyroid (SFTTs) are extremely rare, accounting for only 0.1% of all thyroid tumors. The gold standard imaging modality for thyroid tumors is ultrasonography, even though distinctive characteristics for these types of neoplasms are absent, making pre-operative diagnosis more challenging. : The aim of this study is to perform a systematic literature review and to describe our case by analyzing the main clinical features, histological diagnostic features and treatments of this rare tumor, in order to clarify the behavior and molecular characteristics of SFTTs. : A comprehensive systematic literature review was conducted according to the PRISMA guidelines for SFTTs. We searched the PubMed and EMBASE databases for articles published up to November 2025. The inclusion criteria include confirmed diagnosis of SFTT, while articles describing unrelated neoplasms or articles that were not in English were excluded. A standardized form was used to extract information on the imaging characteristics, histological diagnosis, treatment and outcome. : As of 2025, a total of 43 articles were selected, with 61 reported cases of SFTT in the English literature. Pre-operative diagnosis of SFTT is controversial and usually requires immunohistochemical confirmation. In our case, molecular analysis identified, for the first time, a NAB2ex6-STAT6ex17 fusion, contributing to the molecular characterization of this rare tumor. : SFTTs are rare and difficult to diagnose; thus, they require a multidisciplinary approach for accurate diagnosis and management. The combination of imaging, cytology, histopathology, and molecular testing is essential in distinguishing SFTTs from other thyroid malignancies. Surgical excision remains the mainstay of treatment, and long-term follow-up is recommended due to the potential risk of recurrence or metastasis. - Source: PubMed
Publication date: 2026/04/01
Lauretta RosaPuliani GiuliaBianchini MartaMormando MarildaFasciglione AntoniettaBagaglini Maria FlaviaMarandino FerdinandoAppetecchia Marialuisa - Microglia-mediated neuroinflammation is a key determinant of ischemic brain injury. Electroacupuncture (EA) is known to promote M2 polarization of microglia by upregulating Signal Transducer and Activator of Transcription 6 (STAT6) / Peroxisome Proliferator-Activated Receptor γ (PPARγ), however, the epigenetic mechanism governing the transcriptional stability and recruitment efficiency of this pathway remain poorly understood. We hypothesized that the transcriptional coactivator E1A-binding protein P300 (P300) may serve as a functional partner involved in facilitating this process. To test this, we established a middle cerebral artery occlusion (MCAO) model in mice and evaluated the neuroprotective effects of EA through laser speckle blood flow imaging, gait analysis, and triphenyl tetrazolium chloride (TTC) and Hematoxylin and Eosin (HE) staining. The effects of EA on microglial neuroinflammation were verified via transmission electron microscopy (TEM), immunofluorescence (IF), and Enzyme-Linked Immunosorbent Assay (ELISA). Furthermore, we utilized Western Blot (WB), co-Immunoprecipitation (Co-IP), chromatin immunoprecipitation followed by quantitative polymerase chain reaction (CHIP-qPCR), and CD68 promoter-driven adeno-associated virus (AAV) with P300 shRNA knockdown technology to deeply explore the core mechanism by which P300 regulates the assembly of the STAT6/PPARγ transcriptional complex during EA treatment. Results demonstrated that EA significantly restored cerebral blood flow, reduced infarct volume, and restore neurological function. Moreover, local knockdown of P300 in the ischemic penumbra via CD68 promoter driven AAV significantly attenuated the EA-induced M2 transition. Mechanistically, EA promoted the functional recruitment of P300 to STAT6, which was associated with the enhanced assembly of the STAT6/PPARγ complex on target promoters. In summary, EA promotes M2 polarization by enhancing the stability of the P300 associated STAT6/PPARγ transcriptional complex, providing a novel epigenetic intervention target for ischemic stroke treatment. - Source: PubMed
Publication date: 2026/05/02
Yao ZengyuLai ZhenyiZhang JipingZhang ZhinanXu XiuhongZhao AimeiChen JunqiHuang Yong - The immunosuppressive tumor microenvironment (TME) is a major issue in the malignant progression of glioma patients. The membrane spanning four domains A4A (MS4A4A) has a relationship with M2 polarization of macrophages, and participates in the malignant progression of various cancers. Therefore, exploration of the key role of MS4A4A contributing to glioma biological processes is urgently needed. We performed the bioinformatics analysis of M2 gene expression and built a model predicting the prognosis of glioma patients. Knocking down or overexpressing MS4A4A was achieved in macrophages, and we identified the polarization of macrophages with different MS4A4A expression levels. In vitro and in vivo experiments were used to investigate the role of MS4A4A in regulating M2 polarization and contributing to malignant behaviour in glioma. We found that MS4A4A was associated with the macrophages' M2 scores and the prognosis of GBM patients. MS4A4A had a higher expression level in M2 polarization macrophages. MS4A4A regulates macrophage M2 polarisation through NF-κB and JAK-STAT6 signalling pathways. Macrophages with MS4A4A overexpression promoted the proliferation, invasion, and TMZ-resistance of glioma cells in vitro and in vivo experiments. The treatment targeting the MS4A4A/ NF-κB/STAT6 axis could improve the prognosis and TMZ-resistance in the glioma mouse model. The present study revealed the novel mechanism of the MS4A4A regulating macrophages M2 polarization, contributing to the formation of immunosuppressive tumor microenvironment in glioma through NF-κB/STAT6 signaling pathways, which promotes the malignant biological process of glioma cells. Our results provided new evidence that NF-κB and STAT6 inhibitors might be a potential adjuvant agent in overcoming MS4A4A-mediated chemotherapy resistance in glioma. - Source: PubMed
Publication date: 2026/04/29
Li ZiweiWu ChunfaCui ZhongliangLiang BoWang ChenYu MingchenSun YishuoWang DiZhai YouPan ChangqingZhang JiazhengShi ZhongfangJiang TaoZhang Wei - Adipose-derived mesenchymal stem cell conditioned medium (ADSC-CM) has emerged as a promising cell-free therapeutic strategy for acute lung injury (ALI). ADSC-CM's anti-inflammatory effect is closely related to its ability to regulate alveolar macrophage polarization. Furthermore, autophagy in macrophages is considered to be related to the regulation of polarization. However, the specific role and mechanisms by which ADSC-CM coordinates autophagy to guide macrophage polarization are not yet fully clear and urgently require further research. - Source: PubMed
Publication date: 2026/04/28
Li JiachenYang FanRen ZiyiZhang ChuanyuXing MingweiJiao Zhihui