Ask about this productRelated genes to: GATA1 antibody
- Gene:
- GATA1 NIH gene
- Name:
- GATA binding protein 1
- Previous symbol:
- GF1
- Synonyms:
- ERYF1, NFE1, GATA-1, NF-E1
- Chromosome:
- Xp11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2019-04-23
Related products to: GATA1 antibody
Related articles to: GATA1 antibody
- Erythropoiesis is a complex, spatially constrained morphogenetic process that transforms hematopoietic progenitors into specialized, enucleated red blood cells. While decades of research have defined the cell-intrinsic transcriptional and epigenetic circuits, governed by master regulators such as GATA1 and KLF1, the critical role of the microenvironmental niche remains less understood. Recent advances in single-cell omics have revealed a multi-layered landscape in which transcriptional potential is often uncoupled from proteomic and metabolic output. The transition from dissociative single-cell sequencing to spatially resolved omics further shaped our understanding of how these molecular programs are executed in situ. This chapter summarizes the broader landscape of omics profiling while focusing on how spatial transcriptomics and proteomics are uncovering the anatomical locations of erythropoiesis within the hematopoietic organs. We highlight a significant evolutionary divergence in niche architecture: while murine terminal erythropoiesis is organized with C1q + macrophage-centered erythroblastic islands, human erythropoiesis exhibits a unique, self-sustaining capacity characterized by autonomous erythroblast clustering independent of macrophages. We further discuss the technical hurdles of spatial profiling in mineralized bone and the potential for multimodal spatial omics to link chromatin accessibility, RNA, and protein abundance within intact tissues. By integrating molecular trajectories with microanatomical context, these technologies provide a new framework for understanding ineffective erythropoiesis and identifying therapeutic targets in hematologic diseases. - Source: PubMed
Publication date: 2026/09/05
Wang PanRen KehanJi Peng - Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a dismal prognosis, mainly due to cisplatin resistance and severe adverse effects of conventional therapies. Wogonin, a natural flavonoid, exhibits anticancer activity in several cancers, but its efficacy and potential molecular mechanisms in ESCC remain unclear. - Source: PubMed
Publication date: 2026/08/29
Wei ChengmingShi MeinaWei LiujiaoWei Caituan - Currently, there is no sensitive and specific diagnostic immunohistochemistry (IHC) marker to identify gastric and esophageal adenocarcinomas (GEAs). CDX2 is the most widely used tumor marker to determine gastrointestinal (GI) origin and has been shown to be an excellent marker for lower GI adenocarcinomas, including both small and large bowel adenocarcinomas. However, it has limited utility in upper GI adenocarcinomas, as CDX2 is a key marker for intestinal differentiation and is expressed in fewer than 50% of all gastric adenocarcinomas. In this study, through TCGA data mining, we identified friend of GATA1 (FOG1) as a potential sensitive and specific marker for GEAs, as high mRNA expression levels of FOG1 were found exclusively in GEAs across 29 solid tumor types. We then analyzed FOG1 and CDX2 protein expressions by IHC in 187 cases of GEA and esophageal squamous cell carcinomas (eSCC) and found that neither FOG1 nor CDX2 was expressed in eSCC. In contrast, the majority (91.1%) of GEAs showed moderate to high FOG1 expression, whereas 51.3% of GEAs demonstrated negative to low CDX2 expression. Only 4 (2.5%) GEAs showed moderate to high CDX2 expression with negative to low FOG1 expression. Conversely, among 168 cases of colonic adenocarcinoma, most (71.4%) exhibited intermediate-to-high CDX2 expression, whereas 92.9% showed negative-to-low FOG1 expression. Only 5 (3%) colonic adenocarcinomas demonstrated moderate-to-high FOG1 expression with negative-to-low CDX2 expression. Moderate to high FOG1 expression was detected in a small proportion of pancreatic (15.5%) and ampullary (11.2%) adenocarcinomas, but was rare (1.6% to 3.3%) in adenocarcinomas of the breast, lung, and ovary. In addition, there were no FOG1 expressions detected in lung squamous cell carcinoma, hepatocellular carcinoma, melanoma, and carcinomas of the salivary gland, thyroid, bladder, kidney, prostate, and uterus. Our data indicate that FOG1 is not only a sensitive, but also a specific marker for gastroesophageal adenocarcinoma. - Source: PubMed
Publication date: 2026/09/10
Wang YaohongYin FengYao JunTan DongfengHuo LeiSun HongxiaLu WeiKhan Khaja BSolis Soto Luisa MKostousov Larisa VGan QiongZhao ShilinShakhtour RandPeng YanZhao JianpingZhang DongweiLiu JinsongChen HuiAlbarracin Constance TWu YunSahin Aysegul AWang HuaminDing Qingqing - To review advances from the past 18 months in allogeneic hematopoietic stem cell transplantation (HSCT) and autologous gene-modified stem cell transplantation for sickle cell disease (SCD), and to relate these developments to stem cell biology, conditioning and emerging prenatal strategies. - Source: PubMed
Publication date: 2026/09/09
Mackina GiulaShangaris Panicos - Congenital Dyserythropoietic Anemia type I (CDA-I) is an autosomal recessive disease characterized by anemia due to ineffective erythropoiesis and results primarily from mutations in CDAN1, which encodes CODANIN1. Research efforts to understand the CDA-I pathogenesis have been impeded by the embryonic lethality of germline Cdan1 deleted mice as well as mice deleted for Cdan1 in the erythroid compartment, using the constitutively active EpoR-Cre allele. To study the function of CODANIN1 in adult erythropoiesis, we generated mice with inducible erythroid-specific biallelic Cdan1 deletion using the Gata1-CreERT2 allele. Following tamoxifen administration to adult mice, Cdan1 is excised, resulting in features of CDA-I, including anemia, impaired erythroid differentiation, disturbances in erythroblast cell cycle progression, and the finding of 'spongy' heterochromatin in bone marrow erythroblasts. These findings confirm a critical role for CODANIN1 in effective adult erythropoiesis and demonstrate the successful generation of an inducible CDA-I mouse model, which serves as a valuable platform for testing novel therapies for this orphan disease. - Source: PubMed
Publication date: 2026/09/02
Friedman AnnKing Richard AMyers GreggoryYu LeiBergin Ingrid LLin ZesenDrysdale ClaireMullin CareaCruz Edgar DBalbin-Cuesta GinetteLiu Xiaofang LGallagher Patrick JZhu GuojingMcGee BethLang AnnemarieSingh Sharon AEngel James DouglasGallagher Patrick GKhoriaty Rami