Ask about this productRelated products to: c-Jun antibody
Related articles to: c-Jun antibody
- Delirium, an acute medical emergency, significantly impacts older adults, increasing morbidity, mortality and healthcare costs (estimated at $8.8 billion annually in Australia). Environmental modifications in hospital wards are underexplored despite their potential to mitigate delirium's effects. This study evaluated a multidimensional occupational therapy environmental checklist's impact on functional and service outcomes for hospitalised delirium patients compared to standard care. - Source: PubMed
Neale SharonMcKnight ErinDixon ReneeHitch Danielle - Lung cancer, the leading cause of cancer-related mortality, faces significant therapeutic challenges due to chemoresistance. While metabolic reprogramming and circadian disruptions are implicated in tumor progression, their interplay in driving resistance remains unclear. This study identifies BMAL1, a core circadian regulator, as a key driver and potential initiator of cisplatin resistance in non-small cell lung cancer (NSCLC) through metabolic and oxidative stress pathways. We demonstrate that BMAL1 upregulates multidrug resistance protein MRP1 via HIF-1α-driven glycolysis, amplifying lactate production. Lactate activates the TAZ/c-Jun/Snail complex to increase MRP1 expression, establishing a feedforward loop that sustains chemoresistance. Furthermore, cisplatin and etoposide induce BMAL1 expression through AKT signaling in response to oxidative stress, creating a self-reinforcing resistance mechanism. Critically, targeting AKT or MRP1 reverses BMAL1-mediated resistance. These findings reveal BMAL1 as a metabolic orchestrator linking circadian dysfunction to chemoresistance and propose actionable strategies-such as AKT inhibition or chronotherapy-to circumvent therapeutic failure. This work underscores the necessity of targeting circadian-metabolic crosstalk to improve outcomes in NSCLC. - Source: PubMed
Shi ZixinQin ZiniuChen ChuantaoYang XiaolinHu YunhanMeng XiaohuiCao YuxiangTao XiangZhang ZhijianXie TianchengWei HuijunWu Zhihao - Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific role in driving lung cancer-associated cachexia remains inadequately defined. This study investigated the mechanistic role of Ido1 in cancer cachexia and evaluated the therapeutic potential of its inhibition. - Source: PubMed
Han LengJing LingjieZhu XintingLi CiqinBai LuFang YangZhou YuxuanBai DingyuanLu JinHan YonglongGuo ChengZhou ShuminYang Quanjun - This study evaluates the antioxidant activity of a topical water-in-oil cream formulated with saffron (Crocus sativus) and grape seed (Vitis vinifera) extracts and characterizes its physicochemical properties. HPLC profiling confirmed that grape seed extract was rich in catechins (26.7%), epicatechins (21.9%), and procyanidins B1 and B2 (13.6% and 9.5%), while saffron extract contained high levels of trans-4-GG-crocin (28.4%), trans-2-gg-crocin (23.5%), and picrocrocin (13.4%). In vitro assays using human lymphocyte cultures demonstrated that saffron extract (2.5%) reduced fast-flash chemiluminescence from 36.1 × 104 to 14.3 × 104, while grape seed extract (5.0%) decreased the same parameter to 16.3 × 104. Light-sum ROS output similarly declined by 39%-50% across extract concentrations. Gene expression analysis revealed significant upregulation of SOD1, NFE2L2, and JUN, indicating activation of endogenous antioxidant pathways. The final cream formulation, containing 2.5% saffron and 5.0% grape seed extract, exhibited a stable pH of 5.9, viscosity of 31,869 cP, and spreadability of 24.32 g/cm/s, with no observed irritancy during application tests. These results demonstrate that combining crocin-rich saffron and proanthocyanidin-rich grape seed extracts have a synergistic antioxidant effect and can be successfully incorporated into a stable, skin-compatible topical preparation. The formulation shows promise as a dermal antioxidant therapy aimed at reducing oxidative stress and supporting skin rejuvenation. - Source: PubMed
Zam WissamAlkhaddour AzizHousheh Samer - High‑altitude polycythemia (HAP) is classically attributed to erythropoietin (EPO)‑driven erythrocytosis, yet epidemiological and mechanistic evidence increasingly challenges this monocular view. Field data have demonstrated that up to 40% of individuals with a hematocrit level >68% circulate EPO within the sea‑level reference range, whereas multi‑omics studies have revealed sustained HIF activity, mitochondrial oxidative stress, iron dysregulation, gut dysbiosis and epigenetic reprogramming as parallel, EPO‑independent drivers. Hypoxia‑inducible microRNAs, hepcidin suppression, TLR4‑IL‑6 signaling and defective mitophagy converge to lock erythroid precursors into a survival‑plus‑proliferation state even after ambient oxygen levels normalize. The purpose of the present review is to integrate these disparate pathways into a unified molecular framework and to outline a phased, biomarker‑guided therapeutic roadmap for the precise prevention of maladaptive polycythemia at high altitudes. - Source: PubMed
Publication date: 2026/04/24
Li HaiyanZhang HongjuanZhang HujunLi YujieHe YigangLuan Jia