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- Carbapenem-resistant (CRPA) poses a major therapeutic challenge due to the limited number of available treatment options. Imipenem-relebactam (IMP-REL), a carbapenem combined with a Class A/C -lactamase inhibitor, has demonstrated activity against selected multidrug-resistant isolates. This retrospective, observational, analytical, laboratory-based study represents one of the early reports from Saudi Arabia and the Middle East and North Africa (MENA) region evaluating the activity of IMP-REL using archived clinical isolates with prospectively performed testing, and examining its association with carbapenem minimum inhibitory concentrations (MICs) and -lactamase classes. - Source: PubMed
Publication date: 2026/05/07
Alsharidi Aynaa IAlhumaidi Rand AAlbarrag Ahmed MAl-Tawfiq Jaffar ASomily Ali M - Mucus is believed to be central to the progressive nature of cystic fibrosis lung disease. Poor clearance leads to plugging, inflammation, and infection, driving a cycle that eventually results in irreversible lung damage. We hypothesized that patients with higher mucus burden would demonstrate greater improvement in spirometry and ventilation when treated with modulator therapy. - Source: PubMed
Publication date: 2026/05/23
Matheson Alexander MPrather EvanWillmering Matthew MMata JaimeSantyr GilesRatjen Felix AKramer Elizabeth LCleveland Zackary IWoods Jason C - Large language models (LLMs) are increasingly used for information seeking and self-guided support, raising safety concerns in high-risk contexts such as suicidal ideation. While prior work suggests LLMs can detect suicidal language, their ability to calibrate responses across suicide risk levels remains unclear. This pilot study evaluated Gemini 2.5 Flash using 60 Self-Directed Violence Classification System (SDVCS) clinical vignettes spanning non-suicidal distress (L0), suicidal ideation without plan (L1), and imminent suicide risk (L2) (n=20 per level). Outputs were coded for seven response elements: relational support (REL), reflection (REF), psychoeducation (PSY), coping skills (COP), action orientation (ACT), risk acknowledgment (RISK), and crisis resources (INFO). REL and ACT were common across levels. Safety escalation elements increased with risk levels whereas PSY declined with increasing risk and COP was present only at no suicidal risk level. Notably, the model failed to recognize implicit suicidality in an ambiguous ideation vignette. Overall, Gemini 2.5 Flash approximated clinical triage patterns but demonstrated critical limitations in detecting indirect suicidal expressions. These findings suggest that general-purpose LLMs may support supervised triage research and training but remain unsuitable for autonomous crisis intervention. - Source: PubMed
Keskin YesimPark TriciaBozkurt Selen - Cardiac dysfunction is a major cause of high mortality in sepsis. A well-organized cardiac microenvironment, consisting of cardiomyocytes and non-cardiomyocytes, is essential for maintaining heart function. The mechanism is still unclear. - Source: PubMed
Publication date: 2026/05/21
Zhou YuanqunZhu YuWu YueYang ShunxinXiang XinmingOuyang XingnanLi QinghuiWang XiaodanWang LiLiu LiangmingLi Tao - Carbapenem-resistant Enterobacterales (CRE) pose a severe and growing threat to global public health, with limited clinically available therapeutic options. This study aimed to evaluate the antibacterial efficacy of tebipenem (TEB) combined with the novel β-lactamase inhibitors avibactam, relebactam, and vaborbactam, both in vitro and in vivo, against a panel of 77 clinical isolates of KPC-producing Enterobacterales. - Source: PubMed
Publication date: 2026/05/21
Zou ChunhongShen JinyiShang LishaWang WenLi XueYu JieLi YujinXu WenxinHe QiongyaoChen LiangGe QunfangWang DeqiangWang ShileiNiu Siqiang