Ask about this productRelated genes to: MDM2 antibody
- Gene:
- MDM2 NIH gene
- Name:
- MDM2 proto-oncogene
- Previous symbol:
- -
- Synonyms:
- HDM2, MGC5370
- Chromosome:
- 12q15
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-10
- Date modifiied:
- 2017-12-01
Related products to: MDM2 antibody
Related articles to: MDM2 antibody
- abnormalities contribute to treatment resistance and poor prognosis in multiple myeloma (MM), yet their functional consequences remain unclear. Here, we integrate drug sensitivity profiling, genomics, transcriptomics, and proteomics across 167 CD138 bone marrow patient samples to characterize -associated vulnerabilities. Genome-wide CRISPR-Cas9 and RNAi screening identify vulnerabilities in -mutated MM, with or without del(17p), highlighting the dependency on spindle organization, mitotic regulation, DNA synthesis, and transcriptional and metabolic regulation, but independence from . CD138 cells with mutation exhibit increased sensitivity to chemotherapeutics, HDAC, HSP90, IGF1R, and PI3K/AKT/mTOR inhibitors as well as RNA synthesis inhibitor plicamycin, with distinct drug response profiles of MM with del(17p) and WT . Our study provides new insights into refining classification to optimize treatment strategies for high-risk MM. - Source: PubMed
Publication date: 2026/08/06
Tsallos DimitriosIkonen NemoMiettinen Juho JMajumder Muntasir MamunEldfors SamuliVästrik ImreParsons AlunSuvela MinnaDunphy KatieDowling PaulBazou DespinaO'Gorman PeterLievonen JuhaSilvennoinen RaijaAnttila PekkaHeckman Caroline A - Pelvic solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm with marked clinical and radiological heterogeneity, posing significant diagnostic challenges. Standardized management strategies remain lacking for special clinical scenarios, including paraneoplastic syndromes, synchronous primary malignancies, and pregnancy-associated incidental diagnosis. - Source: PubMed
Publication date: 2026/07/31
Yang XinjiLiu LeiHou Xiaofei - Although cytarabine remains a cornerstone chemotherapeutic agent for Acute lymphoblastic leukemia (ALL), its clinical efficacy is frequently compromised by systemic toxicity and resistance mechanisms, notably telomerase activation via hTERT upregulation. This study investigates the synergistic potential of Zataria multiflora extract (ZME) combined with cytarabine to induce apoptosis in pre-B ALL cells (NALM-6) and explores the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/08/14
Pilehvari NiloofarFatemi AhmadLashkari MahlaValandani Hajar MardaniAshoub Muhammad HosseinKhalilabadi Roohollah Mirzaee - Low-grade central osteosarcoma (LGCO) is a rare subtype of osteosarcoma, accounting for approximately 1-2% of cases. It typically exhibits indolent behavior but poses a diagnostic challenge due to its close radiologic and histologic resemblance to benign fibro-osseous lesions. Although LGCO generally has a favorable prognosis, it may undergo high-grade transformation, leading to more aggressive clinical behavior. - Source: PubMed
Patel TarangSingh GyanendraBhankhodia VaishaliDangar Avani MThesiya YashGupta Akshat - Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) is the most common liposarcoma subtype, but foot and ankle involvement is exceptionally rare, and plantar heel presentation is particularly uncommon. Such lesions may mimic benign soft-tissue masses, raising the risk of delayed diagnosis or unplanned excision and poorer oncologic outcomes. This case reports a rare sclerosing ALT with prominent myxomatous features arising in the plantar heel, confirmed by diffuse MDM2 immunohistochemical positivity; reports of this specific presentation are extremely limited in the literature. The case underscores the need for a broad differential in persistent or enlarging plantar masses, diagnostic use of magnetic resonance imaging (MRI) and histopathology, and planned excision with negative margins followed by long-term surveillance. - Source: PubMed
Khan MohammadAhmed SufiyanMustafa AsadAsghar SairahHossain Mohammad