Ask about this productRelated genes to: MDM2 antibody
- Gene:
- MDM2 NIH gene
- Name:
- MDM2 proto-oncogene
- Previous symbol:
- -
- Synonyms:
- HDM2, MGC5370
- Chromosome:
- 12q15
- Locus Type:
- gene with protein product
- Date approved:
- 1993-12-10
- Date modifiied:
- 2017-12-01
Related products to: MDM2 antibody
Related articles to: MDM2 antibody
- Hepatocellular carcinoma is one of the major cancer related causes of mortality all over the world that is mainly caused by successive activation of PI3K/Akt/mTOR signalling axis and subsequent regulation of autophagy by the medium. This review analyses the molecular picture of PI3K/Akt/mTOR pathway in liver cancer, such as PTEN, receptor tyrosine kinase, Akt isoform, mTOR complex, GSK 3Β, CREB, FOXO protein, MDM2 p53 axis, NF kB, and lipid metabolic controller. The dual role of autophagy as a tumour suppressive and tumour promoting process is particularly focused on in regard to the therapeutic resistance to agents like sorafenib. The review summarizes preclinical evidence demonstrating that major classes of phytochemicals, including polyphenols, flavonoids, alkaloids, and terpenoids, target key regulatory components of the PI3K/Akt/mTOR mediated autophagy network. These substances regulate the ULK1 activation, AMPK signalling, reactive oxygen species processes and autophagy crosstalk to apoptosis, and hepatocellular carcinoma model metabolic remodelling. The in vitro and in vivo studies done using the mechanism of action reinforce the idea that phytochemicals are multi target regulators that can restore cytoprotective and cytotoxic autophagy. Finally, the existing challenges in translational research, such as pharmacokinetic issues, biomarker voids, tumour heterogeneity, and resistance, are critically evaluated to set priorities of introducing phytochemicals into the liver cancer treatment in a precision-based fashion. - Source: PubMed
Publication date: 2026/09/17
Lal PoonamPatel Jitendra - Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease globally. Tubular injury represents an early pathological hallmark of DKD and a core driver of disease progression. By comparing single-cell RNA sequencing (scRNA-seq) data of kidney samples from healthy controls and DKD patients, we found significantly upregulated S100 calcium-binding protein A1 (S100A1) expression in the proximal tubules of DKD patients, while its role and regulatory mechanism in DKD pathogenesis remain largely unclear. Analysis of renal biopsy specimens from DKD patients showed that S100A1 was markedly upregulated in proximal tubules, and its expression level was significantly correlated with 24-h proteinuria, serum creatinine, and estimated glomerular filtration rate (eGFR). In vitro, S100A1 promoted tubular injury, inflammatory cytokine release, and fibrotic responses in high glucose-stimulated human proximal tubular epithelial cells (HK-2). Mechanistically, S100A1 enhanced the interaction between E3 ubiquitin ligase MDM2 and transcription factor Krüppel-like factor 15 (KLF15), induced K48-linked ubiquitination and proteasomal degradation of KLF15, relieved KLF15-mediated transcriptional repression of inhibitor of DNA binding 1 (ID1), and ultimately aggravated tubular injury. In vivo, proximal tubule-specific knockdown of S100A1 attenuated renal injury, inflammatory infiltration, and fibrosis in diabetic mice. Our findings reveal a novel S100A1-MDM2-KLF15-ID1 regulatory axis in DKD pathogenesis. Targeting S100A1 might be a potential therapy for proximal tubular injury in DKD. - Source: PubMed
Zeng ZhitaoShang JiazhenChai ShouyuZhang XiaLv XincongHan XiaotianXu YifanMa BaozeLv ZhimeiWang Rong - PTEN and p53 are two pivotal tumor suppressors that synergistically restrain tumor progression but are frequently inactivated in cancer. Restoring their functions is a promising therapeutic strategy but remains limited by unsustainable protein production and off-target effects. Here, we report a biohybrid platform integrating engineered attenuated Salmonella typhimurium VNP20009 with nanotechnology to enable durable restoration of PTEN and p53 functions in tumors. The bacteria are engineered with a quorum-sensing-regulated lysis circuit coupled to PTEN expression, enabling controlled proliferation and sustained PTEN production and release. Their intrinsic tumor tropism and long-term intracellular parasitism allow them to function as exogenous organelle mimics, providing continuous PTEN supplementation. Surface-conjugated nanoparticles further deliver the MDM2 inhibitor to stabilize p53 and synergistically restore the PTEN-p53 network. This platform achieves 94.9% tumor inhibition in murine melanoma and confers durable survival in all treated mice when combined with anti-PD-1 therapy, highlighting its strong therapeutic potential for cancer treatment. - Source: PubMed
Publication date: 2026/08/17
Bi ShijieWang MaoqinGuan QingWang YaxinLiu RunchangZhang JiayingLi MengLiu QuanWang PengZhang YoumingFu JunLi RuijuanLiu Jun - Low-grade fibro-osseous lesions can be challenging to classify. A 33-year-old man presented with synchronous lesions involving the ilium and T2 vertebra. Because of an impending pathologic fracture, he received several doses of denosumab. Initial biopsies showed bland fibro-osseous lesions lacking GNAS or MDM2 alterations and were favored to represent polyostotic fibrous dysplasia. Subsequent iliac curettage revealed a fascicular spindle cell proliferation with subtle atypia and focal ossification, leading to a revised diagnosis of low-grade fibrosarcoma. Re-biopsy of the T2 lesion demonstrated a similar spindle cell proliferation without ossification. Sequencing identified copy number gains involving KIT, PDGFRA, and TERT. At 16-month follow-up, two metastatic pulmonary nodules developed, one responsive to chemotherapy. The patient remains alive with disease at 27 months after presentation. This case highlights a diagnostic pitfall in which low-grade fibrosarcoma with denosumab-associated ossification may mimic fibrous dysplasia and underscores the prognostic value of molecular profiling beyond histologic grading. - Source: PubMed
Publication date: 2026/08/03
Shi Wangpan JHuang Brady KLei Li - Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma that is histologically and clinically heterogeneous. Skeletonization is a computer vision technique used in image description, segmentation, and pattern recognition. - Source: PubMed
Publication date: 2026/09/01
Carreras JoaquimKikuti Yara YukieNagase ShunsukeRoncador GiovannaIkoma HarukaIto AtsushiOrita MakotoTomita SakuraTanigaki YukiUeno AkihisaKondo YusukeNakamura NaoyaMasugi Yohei