Ask about this productRelated genes to: CDK6 antibody
- Gene:
- CDK6 NIH gene
- Name:
- cyclin dependent kinase 6
- Previous symbol:
- -
- Synonyms:
- PLSTIRE
- Chromosome:
- 7q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-14
- Date modifiied:
- 2019-04-23
Related products to: CDK6 antibody
Related articles to: CDK6 antibody
- Hepatocellular carcinoma (HCC), a leading cause of death worldwide, is primarily caused by uncontrolled cellular proliferation, invasion and metastasis leading to tumor development in the liver. miR-195 regulates G1 to S phase transition in the cell cycle by targeting CDK6. In the current study, expression of miR-195 was significantly reduced while that of CDK6 was upregulated in HCC patients. The results of expression analysis were supported by the Pearson correlation coefficient indicating a moderate negative (r = -0.459, p = 0.02) relation between miR-195 and CDK6. However, the association of miR-195 and CDK6 with age and sex was not statistically significant. The predicted secondary and tertiary structures of miR-195 showed the presence of loops, stems, and flanking regions. Further, in silico analysis identified potential amino acid residues in CDK6, CDK4 and Cyclin D1 proteins interacting with the miR-195. We designed a mimic RNA of miR-195 by mutagenesis at 4 points. The mimic RNA_3 of miR-195 presented a well-defined stable structure showing strong binding interactions with CDK4 and Cyclin D1 and comparable interactions with CDK6. In conclusion, our study has demonstrated the potential of using miR-195 mimic RNA as a therapeutic strategy to target the CDK6 gene in HCC with reduced miR-195 expression. - Source: PubMed
Publication date: 2026/04/24
Wali TayyabaEjaz SaimaZahra Shan ERehman Arif Mian AbdurHussain FatmaShahid MuhammadBaigum MuafiaNudrat AtiqaNaz FarihaZia Saadiya - Osteoarthritis (OA) is characterized by chondrocyte senescence involving inflammation, oxidative stress, and cell cycle dysregulation. Quercetin, a natural flavonoid, has multi-target potential, but its mechanism in OA chondrocyte senescence remains incompletely understood. - Source: PubMed
Publication date: 2026/04/22
Hu ZhihuaChen YongxinYao YitaoYang XiaoLi Gan - Analysis of runs of homozygosity (ROH) in commercial breed genomes is important for accurately assessing the population inbreeding status and exploring homozygous regions related to economic traits formed by selection pressure. The Danish Large White (LW) pig is a commercially important breed renowned for its superior growth efficiency and reproductive performance. In the present study, we identified ROH segments of Danish LW pigs based on 43 individual whole-genome resequencing data. We then calculated the inbreeding coefficient and screened candidate genes with important economic traits from the ROH islands. A total of 9446 ROH segments were identified in the LW pig population. Each LW pig carried 219.67 ROH. Most ROH were , and the average genomic inbreeding coefficient ( ) in LW pigs was 0.24. However, the proportion of ROH ( ) in LW pigs has reached 10 %, indicating selection pressure or inbreeding in recent times. Candidate genes related to reproductive traits (, , , , , , and ), and growth and development traits (, , , , , , , , , , and ) were identified in the genomic ROH islands of LW pigs. In conclusion, the present study provides further assessment of genetic diversity and inbreeding in the Danish LW pig population. In addition, our results provide useful insights into the functions of ROH on a hereditary basis and the role that ROH play in controlling the excellent characteristics of Danish LW pigs. - Source: PubMed
Publication date: 2026/01/12
Ding WeiminWu XudongBu YuZhang WeiWang YuanlangDing YueyunZheng XianruiZhang XiaodongYin Zongjun - We conducted this study to evaluate the impact of serum inflammatory markers and histopathological features on prognosis in metastatic hormone receptor positive breast cancer patients treated with first line CDK4/6i (cyclin-dependent kinase inhibitors). - Source: PubMed
Bulut NiluferKapagan TanjuOzmen AykutErdem Gokmen Umut - Integrin beta 4 (ITGB4) has been implicated in breast cancer progression, yet its clinical utility as a biomarker remains unclear due to inconsistent findings across studies. This discrepancy may stem from the failure to distinguish between RNA and protein levels. - Source: PubMed
Zhu Zhi-MinHu LeiMa Yan-WenZhu Qiong-Ni