Ask about this productRelated genes to: ERBB3 antibody
- Gene:
- ERBB3 NIH gene
- Name:
- erb-b2 receptor tyrosine kinase 3
- Previous symbol:
- LCCS2
- Synonyms:
- HER3
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-15
- Date modifiied:
- 2019-04-23
Related products to: ERBB3 antibody
Related articles to: ERBB3 antibody
- ErbB ligands activate distinct receptor dimers that regulate cell proliferation, but how they influence cell-cycle commitment remains unclear. Here, we show that EGF and HRG induce different modes of G1/S progression in ErbB2-amplified BT474 breast cancer cells. Unexpectedly, HRG, despite activating the more potent ErbB2-ErbB3 heterodimer, failed to accelerate G1/S progression; instead, EGF promoted earlier passage through the restriction point and faster S-phase entry. Mechanistically, EGF drove rapid and coordinated cell-cycle progression through ERK-FOS signaling, whereas HRG induced sustained MYC activity, elevated transcriptional heterogeneity, and caused extensive rewiring of cell-cycle regulatory networks. Together, these findings reveal that ligand-specific ErbB signaling controls not only the timing of cell-cycle entry but also the transcriptional architecture that governs proliferative fate decisions. - Source: PubMed
Publication date: 2026/08/21
Febri Ririn RahmalaNagasato-Ichikawa AyakaIida KeitaKimura ShuheiImamoto AkiraOkada Mariko - Cutaneous apocrine carcinoma is a rare adnexal malignancy with limited evidence guiding treatment in the metastatic setting. We present the case of a 50-year-old man with hormone receptor-positive metastatic cutaneous apocrine carcinoma of the right axilla initially treated with surgical excision, nodal resection, and adjuvant radiation therapy. He later developed metastatic recurrence involving the spine and lungs, requiring surgical stabilization. Molecular profiling demonstrated a KMT2C mutation, microsatellite-stable disease, low tumor mutational burden, and overexpression of ERBB2 (Erb-B2 receptor tyrosine kinase 2/HER2), ERBB3 (Erb-B3 receptor tyrosine kinase 3/HER3), NFKB1 (nuclear factor kappa B subunit 1), CCND1 (cyclin D1), RET (RET proto-oncogene receptor tyrosine kinase), and AR (androgen receptor) pathways, while immunohistochemistry showed strong estrogen receptor positivity, androgen receptor expression, and HER2 negativity (unusual given the ERBB2 positivity). The patient later received sequential therapy with tamoxifen, pembrolizumab, androgen deprivation therapy, and, most recently, palliative radiation, followed by carboplatin/paclitaxel for progressive disease complicated by spinal cord compression. His clinical course was further complicated by severe neutropenia, radiation esophagitis, and chemotherapy-induced peripheral neuropathy. This case highlights the therapeutic complexity of metastatic cutaneous apocrine carcinoma and demonstrates the potential for meaningful disease control with endocrine and immune-based therapies despite progression through multiple lines of treatment. Given the absence of a standard treatment paradigm, more investigation in larger cohorts is needed to validate the role of these treatment approaches in improving outcomes in metastatic apocrine carcinoma. - Source: PubMed
Publication date: 2026/07/21
Chan Bryan LIguh ChikaHwang AndrewHuang Charity - Deficiency in SWItch/Sucrose Non-FermenTable (SWI/SNF) related barrier-to-autointegration factor (BAF) chromatin remodeling complex subunit ATPase 4 (SMARCA4) drives aggressive behavior across various undifferentiated malignancies. However, its clinicopathological features, prognostic analysis, and molecular significance in undifferentiated digestive system malignancies, clinically rare and poorly characterized entities, remain incompletely elucidated. This study investigated the clinicopathological characteristics and prognostic significance of a retrospective cohort (n = 43). Immunohistochemistry (IHC) identified SMARCA4 deficiency in 30.2% of undifferentiated malignant tumors of the digestive system. Clinically, SMARCA4 deficiency constituted a significant poor-prognosis predictor, correlating with poorer overall survival [OS; hazard ratio (HR) = 3.054, 95% confidence interval (CI) 1.277-7.306, log-rank p = 0.006] and disease-free survival (DFS; HR = 2.717, 95% CI 1.129-6.539, log-rank p = 0.015), independent of assessed lineage markers or microsatellite status. Integrated analysis of The Cancer Genome Atlas (TCGA) data of digestive system malignancies revealed that SMARCA4-mutated tumors exhibited elevated tumor mutational burden (TMB) and distinct co-mutation patterns. Notably, SMARCA4 mutations significantly co-occurred with multiple potentially actionable therapeutic targets, including receptor tyrosine kinases (ERBB2, ERBB3, MET, and RET), DNA damage response genes (BRCA2), and mismatch repair genes (MLH1, MSH2, MSH6). Collectively, our findings identified SMARCA4 deficiency as a predictor of poor prognoses in digestive system malignancies, suggesting a distinct genomic context that may inform therapeutic stratification, including targeted and immunotherapeutic approaches, by focusing on these high-frequency co-mutated targets. © 2026 The Pathological Society of Great Britain and Ireland. - Source: PubMed
Publication date: 2026/08/20
Guo Yun-RanLiu ChangBai XiaoLi Ke-ChenZhao Jia-BaoLin KunZhao Zi-TingLang Ji-XuanLi Xiao-HanWu Qi-JunZhang Chun-Dong - Age-related cataracts (ARC), a disease associated with aging, is the leading cause of blindness worldwide. To better understand the heterogeneous pathogenesis of ARC and identify potential therapeutic targets, we generate a comprehensive atlas of age-related cataracts at a single-cell resolution, encompassing three disease states-mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N)-with a total of 230 838 lens epithelial cells (LECs) derived from the lens capsules of 554 patients. We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular composition and functional states across disease severities. Unexpectedly, we discover that neuronal axon-like structures ingrowth into the lens is associated with cataractogenesis and its progression. All three disease groups show significant enrichment of the neurotrophic SLIT-ROBO signaling pathway. Cluster 0 exhibits high expression of the neurotrophic factor NRG1, which forms a stable ligand-receptor axis with the ERBB3 receptor on sympathetic neurons. These findings not only reveal the heterogeneity of ARC at the levels of cellular composition and signaling pathways but also suggest that neuro-lens interactions may play a critical role in cataract development. This provides a new perspective for understanding the pathogenesis of age-related cataracts. - Source: PubMed
Publication date: 2026/08/05
Tang QiaomeiTong ZiyangFan ChunmeiChen SilongGuo JiaruiHu JianghuaYao KeYin ZiChen XiaoYu Yibo - Testicular adult granulosa cell tumors (AGCTs) are exceptionally rare neoplasms that are thought to be the male counterpart of ovarian granulosa cell tumors (GCT). Here, we present a 50-year-old African American male who initially presented with right testicular pain and swelling, with ultrasound revealing a 2.0-cm heterogeneous hypoechoic lesion along the upper pole/interpolar right testicle with internal vascularity. Microscopic examination was consistent with AGCT, demonstrating monomorphic cells with elongated nuclei containing numerous small grooves, resembling ovarian granulosa cells, and scant cytoplasm arranged in trabeculae and sheets. Immunohistochemical stains of the tumor were positive for inhibin, vimentin, and weakly positive for calretinin, S100, and Ki67 (10%). Next Generation Sequencing (NGS) showed low-level amplifications of , , , and . No gene fusions or mutations were identified. The patient underwent a radical orchiectomy and remains alive and disease-free at 42 months following diagnosis. - Source: PubMed
Publication date: 2026/07/28
Moran ChristopherSkibiel CatherineShojaei HadiTomaszewski Jeffrey JEdmonston Tina BockerBarshay VeniaminBirbe Ruth