Ask about this productRelated genes to: HSP27 antibody
- Gene:
- HSPB1 NIH gene
- Name:
- heat shock protein family B (small) member 1
- Previous symbol:
- -
- Synonyms:
- HSP27, HSP28, Hs.76067, Hsp25, CMT2F
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-09
- Date modifiied:
- 2019-04-23
Related products to: HSP27 antibody
Related articles to: HSP27 antibody
- Fucoidan is a sulfated polysaccharide from brown seaweed such as sugar kelp (Saccharina latissima) that has bioactive properties including immunomodulatory, antioxidant, and antimicrobial effects. This current study investigated the modulation of the intestinal immune profile of pre-smolts Atlantic salmon (Salmo salar) by dietary fucoidan. To do this, a 5-week experiment, consisting of triplicate tanks with 40 fish per tank, was conducted using either a commercial-like diet (control) or a diet containing 0.2% fucoidan. Afterwards, shotgun proteomics, enrichment analysis, and the detection of specific biomarkers (by immunohistochemistry or ELISA) were performed. Key results in distal intestine (DI) revealed that fish fed fucoidan increased the presence of CD8 cells, as well as proteins linked to degradation of branched-chain amino acids, tight junctions, NOD-like receptors, TGF-beta and PPAR signalling. Furthermore, immunological pathways (e.g., complement, antigen processing and presentation, T cell receptor signalling, leukocyte migration, and neutrophil extracellular trap formation) were enriched in fucoidan group along with higher number of chromosome-associated proteins (e.g., histone H2A, nucleosome assembly protein 1-like 4), chaperones (e.g., HSP60, HSP90A, HSPB1) and lectins (e.g., mannose-binding proteins). Also, DI from the fucoidan group showed the enrichment of CD markers including CD29, CD61, CD63 or CD243, which have been reported during cell trafficking (including CD8 cells). This analysis proposes the potential involvement of CD8 cells along with other leukocytes in the remodeling of intestinal immunity of fish under nutritional programming. Overall, the current findings showed that fucoidan can modulate innate and adaptive immune mechanisms, making it an interesting candidate for functional aquafeeds. - Source: PubMed
Publication date: 2026/04/10
Purushothaman KathiresanMorales-Lange ByronRocha SérgioD CQingsong LinMercado LuisØverland MargarethPress Charles McLean - - Source: PubMed
Publication date: 2026/04/10
Huang LiuZheng ChengHe CuizhuQiu XiangWei HuiqingYan JieCui KunYang WenhuiYao LizhuoWei YulianNie XiaohongGuo Bingyan - Febrile seizures (FS) induced by hyperthermia are typically accompanied by inflammation, but how heat induces an inflammatory response is still unclear. - Source: PubMed
Publication date: 2026/03/17
Zhu HuaqiangChen QianYan TianciLu HanyuLi LangfanSong QinDu LijingHuang HaiwenShen SicongHe JunyaoFan XiaohuiPeng Xin - TAR DNA-binding protein 43 (TDP-43) is a nucleic acid-binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C-terminal low-complexity domain (TDP-43). TDP-43 aggregation and condensation are associated with neurodegenerative disease. However, the proteostasis mechanisms that regulate these processes remain elusive. Some evidence has shown that the molecular chaperone small heat shock protein HspB1 binds to and regulates the cytoplasmic phase separation of TDP-43, indicating that other small heat shock proteins may have similar effects. Here, we demonstrate divergent behaviors for HspB1 and its homolog HspB5 on TDP-43 condensation and aggregation. In addition to inhibiting TDP-43 aggregation, HspB1 partitions into TDP-43 condensates and increases the dynamic exchange of TDP-43 within condensates and with the surrounding solution. Phosphorylation-mimicking mutations within HspB1 enhance these effects. HspB5 inhibits TDP-43 aggregation more effectively than HspB1 and partitions into TDP-43 condensates, where it delays the pathological transition of the condensate to a gel/solid. We identify the N- and C-terminal regions of HspB1 and HspB5 to be crucial for the chaperone effects, and highlight the role of sequence diversity within these regions in defining small heat shock protein function. These findings demonstrate that HspB1 and HspB5 are regulators of TDP-43 phase separation and aggregation and may be potential therapeutic targets in mitigating toxic TDP-43 aggregation in neurodegenerative disease. - Source: PubMed
Walker Thomas BTrowbridge Joshua WMcMahon ShannonMarzano Nicholas RRice LaurenYerbury Justin JEcroyd HeathMcAlary Luke - Trigeminal neuralgia (TN) is a neuropathic pain disorder with a marked female predominance. While transcriptional changes in TN are documented, the translational and post-translational landscapes-specifically protein abundance and phosphorylation states-within the trigeminal ganglion (TG) remain largely unexplored. Understanding these layers is essential to deciphering the mechanisms behind the disease's sexual dimorphism. - Source: PubMed
Publication date: 2026/03/03
Zhai XiaojieLin XianghongZhang LinlinRen YuxuanMiao HeMiao MengmengChen YijunZhang YiweiHuang Changshun