Ask about this productRelated genes to: NMDAR2B antibody
- Gene:
- GRIN2B NIH gene
- Name:
- glutamate ionotropic receptor NMDA type subunit 2B
- Previous symbol:
- NMDAR2B
- Synonyms:
- GluN2B
- Chromosome:
- 12p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-18
- Date modifiied:
- 2016-02-05
Related products to: NMDAR2B antibody
Related articles to: NMDAR2B antibody
- Neuropsychiatric symptoms can emerge early in Alzheimer's disease (AD), but whether innate fear is altered prior to amyloid plaque deposition remains unclear. This study aimed to examine innate fear responses in young adult male APP/PS1 mice and to evaluate whether D-cycloserine (DCS) rescues such deficits via GluN2B-containing NMDA receptors. Male APP/PS1 mice (2-3 months old) exhibited impaired innate fear responses in the looming disk test, while their motor function and contextual fear memory remained intact. Hippocampal Grin2b expression was reduced in the APP/PS1 mice. DCS restored normal fear responses, an effect blocked by GluN2B antagonists but unaffected by GluN2A inhibition. Our results demonstrate that innate fear deficits emerge early in male APP/PS1 mice and are rescued by DCS through activation of hippocampal GluN2B-containing NMDA receptor, highlighting a potential target for early AD-related neuropsychiatric symptoms. - Source: PubMed
Publication date: 2026/09/19
Zhang BinWang ZheyeZhao XinjieZhu JiaqiZhang YutongWang YifeiYang JialuCheng JiaqiYang XinyiZhu FengShen WeidaLu Wen - There has been some evidence that neuroinflammation is involved in Parkinson's disease (PD) and in psychiatric disorders. - Source: PubMed
Publication date: 2026/08/31
Gonçalves Alexandra RibeiroMendes AlexandreDamásio JoanaVila-Chã NunoBoleixa DanielaSantos CristinaLeal BárbaraCavaco Sara - Environmental degradation and accumulation of plastics results in micro- and nanoplastics that are small enough to cross biological barriers, including the blood-brain barrier. Microglia, resident immune cells of the brain, are critical regulators of neuroimmune homeostasis and represent a cellular target of nanoplastic exposure. In this study, we assessed the neurotoxic effects of two sizes of polystyrene nanoplastics (PS-NPs; 100 nm and 500 nm) using integrated in vivo and in vitro exposure and washout paradigms. In vivo exposure in mice (60 days; 1.5 mg/day) showed the presence of both PS-NPs sizes in the cerebral cortex without overt histopathological damage. However, cortical microglia showed pronounced morphological remodeling, assessed by Sholl and Skeleton analyses. Transcriptomic profiling of cortical tissue revealed a strong size-dependent response. The 100 nm PS-NPs group revealed 18 DEGs (|log₂FC= ≥ 2, padj < 0.05), whereas the 500 nm PS-NPs showed more than 4000 DEGs, including upregulation of immune- and microglia-associated genes (CCL5, CXCL10, LCN2, LYZ2) and downregulation of synaptic and neuronal signaling genes (GRIN2B, SYN1, STX1B, MAP1B, ITPR1/2). Using BV2 microglial cells, data indicate size dependent internalization of PS-NPs via the endolysosomal pathway. While both the 100 and 500 nm particles were present in late endosomes, only the 100 nm particles were found in lysosomes. Microglial activation markers (Iba1, CD68) exhibited a transient, size- and concentration-dependent increase, correlated with intracellular particle burden rather than cumulative exposure. Overall, these findings demonstrate that PS-NPs reached cortical regions of the brain, driving size-dependent microglial activation and transcriptomic reprogramming, even after cessation of exposure to PS-NPs. - Source: PubMed
Publication date: 2026/09/05
Tavakolpournegari AlirezaKannan UnnikrishnanGregory MaryDufresne JulieCostantino SantiagoLefrancois StephaneCyr Daniel G - This study aimed to explore the protective effect of Agaricus bisporus polysaccharide (ABP) against high-fat diet (HFD) induced cognitive impairment (CI), with a particular focus on gut-brain communication. ABP supplementation alleviated anxiety-like behavior and cognitive deficits in HFD-fed mice. These effects were associated with enhanced hippocampal synaptic plasticity and attenuated inflammatory responses, which were accompanied by the elevation of Bdnf levels and the upregulated expression of plasticity-related genes (e.g., Gria2, Grin2b, Tdp2, and Fxr1). Crucially, ABP supplementation was associated with alleviated HFD-induced morphological changes in microglia and reduced inflammatory factor mRNA levels (Tnf, Il1b). Meanwhile, ABP remodeled the gut microbiome, significantly enriching beneficial taxa including Akkermansia and Bacteroides and enhancing the production of short-chain fatty acids (SCFAs), mainly acetate and propionate. These findings suggest that ABP may serve as a promising nutritional component for alleviating diet-related CI with effect associated with modulation of the microbiota-gut-brain axis. - Source: PubMed
Publication date: 2026/08/07
Fu ChujingYe KaiQiu ZhichangHu XinyuWang XiaoxuanXiao Hang - N-methyl-D-aspartate receptors (NMDARs) play a pivotal role in neurodevelopment. While pathogenic variants in GRIN genes cause a broad spectrum of epileptic and developmental disorders, the precise molecular determinants that drive specific neurodevelopmental courses remain poorly understood. This study aims to utilize high-resolution structural modeling to identify associations between localized conformational alterations in NMDARs and distinct clinical phenotypes. - Source: PubMed
Publication date: 2026/09/01
Wen Si-JiaWang HaoOuyang Shi-JiaZhang Jun-JiaoTan Quan-ZhenLi Shang-RuZhang Yue-HuaWu YeJiang Yu-Wu