Ask about this productRelated genes to: HSP27 antibody
- Gene:
- HSPB1 NIH gene
- Name:
- heat shock protein family B (small) member 1
- Previous symbol:
- -
- Synonyms:
- HSP27, HSP28, Hs.76067, Hsp25, CMT2F
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-09
- Date modifiied:
- 2019-04-23
Related products to: HSP27 antibody
Related articles to: HSP27 antibody
- Fish oil (FO) has been shown to confer beneficial effects on hepatic diseases in both humans and animals. This study aimed to investigate whether dietary fish oil (FO) supplementation alleviates deoxynivalenol (DON)-induced liver injury by modulating the ferroptosis signaling pathway in weaned piglets. Twenty-four weaned piglets were allocated to a 2 × 2 factorial design, with the main factors consisting of dietary treatment (5% corn oil or 5% FO supplementation) and DON exposure (basal diet or diet contaminated with 4 mg/kg DON). After 21 days of dietary treatment, piglets were euthanized for collection of blood and liver samples. Dietary FO significantly attenuated DON-induced hepatic structural damage and inflammatory infiltration. Specifically, FO supplementation reduced the activities of aspartate transaminase (AST) and alkaline phosphatase (ALP), as well as the AST/alanine aminotransferase (ALT) ratio following DON exposure. Dietary FO also decreased malondialdehyde (MDA) concentrations in both the liver and serum, lowered hepatic 4-hydroxynonenal (4-HNE) level and Fe content, and increased hepatic glutathione (GSH) content. Moreover, dietary FO ameliorated ultrastructural liver damage induced by DON. Furthermore, DON significantly downregulated the mRNA levels of multiple genes associated with iron metabolism and ferroptosis, including heat shock protein beta-1 (HSPB1), acyl-CoA synthetase long chain family member 4 (ACSL4), and arachidonate 15-lipoxygenase (ALOX15), and upregulated the mRNA levels of transferrin (TF), ferritin heavy chain (FTH), solute carrier family 7 member 11 (SLC7A11), and transferrin receptor 1 (TFR1). Dietary FO counteracted these alterations by decreasing the mRNA of SLC7A11, TFR1, FTH, and TF after DON exposure. Finally, FO significantly decreased the protein expression of SLC7A11, iron-responsive element-binding protein 2 (IREB2), and FHT1 and increased the GPX4 protein expression following DON exposure. These findings suggest that FO may ameliorate DON-induced liver injury in weaned piglets, possibly through suppressing the ferroptosis signaling pathway. - Source: PubMed
Publication date: 2026/04/17
Liu JiasiZhang MinfangZhou MohanGuo JunjieChen ShaokuiXiao KanLiu Yulan - Follicular development in laying hens requires a balance between angiogenesis and redox status, yet their synergistic interplay across different production levels and physiological stages remains unclear. This study compared high-production (HP) and low-production (LP) hens at 50 and 75 weeks of age using morphological, antioxidant, angiogenic, and transcriptomic analyses. An acute tBHP-induced oxidative stress model was further employed to elucidate the temporal coupling between these systems. - Source: PubMed
Publication date: 2026/05/03
Qin KailongGao MingluLiu XiaoyingLiu YanliYang XiaojunYang Jiantao - Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The primary therapeutic drug for advanced HCC is sorafenib (Sora), but drug resistance severely affects its efficacy. The present study aimed to investigate the role of the transcription factor KLF16 in Sora resistance in HCC. - Source: PubMed
Publication date: 2026/04/27
Kong ShujiaZhao ChenLu FangyiLi Yanwen - -Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the central nervous system and is involved in the development of neural tissue as well as the regulation of its functions. Meanwhile, GABA has also been demonstrated to confer multiple physiological benefits, including alleviating stress and improving metabolic homeostasis. This study investigated GABA effects on proliferation, differentiation, and temperature stress protection of bovine skeletal muscle satellite cells (BSCs). - Source: PubMed
Publication date: 2026/04/14
Manzoor AbidNaseem SajidaFu ZhiqiRuan ChaohuiLiu XuYan ChunriChoi SeonghoLi Xiangzi - Fucoidan is a sulfated polysaccharide from brown seaweed such as sugar kelp (Saccharina latissima) that has bioactive properties including immunomodulatory, antioxidant, and antimicrobial effects. This current study investigated the modulation of the intestinal immune profile of pre-smolts Atlantic salmon (Salmo salar) by dietary fucoidan. To do this, a 5-week experiment, consisting of triplicate tanks with 40 fish per tank, was conducted using either a commercial-like diet (control) or a diet containing 0.2% fucoidan. Afterwards, shotgun proteomics, enrichment analysis, and the detection of specific biomarkers (by immunohistochemistry or ELISA) were performed. Key results in distal intestine (DI) revealed that fish fed fucoidan increased the presence of CD8 cells, as well as proteins linked to degradation of branched-chain amino acids, tight junctions, NOD-like receptors, TGF-beta and PPAR signalling. Furthermore, immunological pathways (e.g., complement, antigen processing and presentation, T cell receptor signalling, leukocyte migration, and neutrophil extracellular trap formation) were enriched in fucoidan group along with higher number of chromosome-associated proteins (e.g., histone H2A, nucleosome assembly protein 1-like 4), chaperones (e.g., HSP60, HSP90A, HSPB1) and lectins (e.g., mannose-binding proteins). Also, DI from the fucoidan group showed the enrichment of CD markers including CD29, CD61, CD63 or CD243, which have been reported during cell trafficking (including CD8 cells). This analysis proposes the potential involvement of CD8 cells along with other leukocytes in the remodeling of intestinal immunity of fish under nutritional programming. Overall, the current findings showed that fucoidan can modulate innate and adaptive immune mechanisms, making it an interesting candidate for functional aquafeeds. - Source: PubMed
Publication date: 2026/04/10
Purushothaman KathiresanMorales-Lange ByronRocha SérgioD CQingsong LinMercado LuisØverland MargarethPress Charles McLean