Ask about this productRelated genes to: VASP antibody
- Gene:
- VASP NIH gene
- Name:
- vasodilator stimulated phosphoprotein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-07
- Date modifiied:
- 2017-06-13
Related products to: VASP antibody
Related articles to: VASP antibody
- Platelets play a central role in thrombus formation, which is a major cause of morbidity and mortality worldwide. Viral infections have been reported to further promote thrombus formation, posing a critical risk in unpredictable pandemic situations. Therefore, we evaluated whether a Korean red ginseng-derived saponin fraction could serve as a safe and effective antithrombotic agent by assessing its inhibitory effects. - Source: PubMed
Publication date: 2026/01/21
Lee Ga HeeOh JueunLee Jin PyoHeo Na YoonLee SangJoonLee Dong-Ha - Platelet hyperactivation and thrombo-inflammatory processes are critical drivers of cardiovascular diseases. Although conventional antiplatelet therapies reduce thrombotic risk, their use is limited by bleeding complications and drug resistance. Ginsenoside Rs3 (G-Rs3) exhibits anti-inflammatory potential; however, the specific mechanisms underlying the antiplatelet and thrombo-inflammatory activity of ginsenoside Rs3 (G-Rs3) remain unclear. - Source: PubMed
Publication date: 2026/03/12
Shin Jung-HaeAkram Abdul WahabSaba EvelynKim Myung ChulKim Sung DaePark Sang JoonKwak DongmiKwon Hyuk-WooRhee Man Hee - To evaluate longitudinal changes in oral health-related quality of life (OHRQoL), pain, and mandibular function over 12 months after temporomandibular joint (TMJ) disc repositioning with mini-anchor fixation in women with refractory bilateral disc displacement without reduction (DDwoR). - Source: PubMed
Publication date: 2026/05/09
Zanin Roberto FerreiraHeitz CláitonDellagostin Bruna MorganWeber AlexandreOmizzolo GuilhermeConci Ricardo AugustoWeber João Batista Blessmann - Nascent adhesions are early integrin-based assemblies that couple the extracellular matrix to the actin cytoskeleton and mature into focal adhesions. Many nascent-adhesion proteins interact through weak, multivalent contacts, suggesting that liquid-like organization may contribute to adhesion assembly. However, how phase separation shapes actin polymerization and organization remains unclear. Here, we compare two vasodilator-stimulated phosphoprotein (VASP)-recruiting adaptor proteins, zyxin and vinculin, to determine how adaptor identity tunes condensate properties and actin coupling. Both zyxin-VASP and vinculin-VASP assemblies drive integrin clustering and support actin filament growth. Notably, zyxin-VASP condensates remain fluid and redistribute along newly formed actin bundles, whereas vinculin-VASP condensates are more rigid and fail to spread along actin despite sustaining polymerization. These results suggest that differential VASP recruitment can modulate condensate properties and actin architecture, providing a potential mechanism for the maturation of nascent adhesions into focal adhesions. - Source: PubMed
Publication date: 2026/05/08
Hordeichyk ArseniiPajanonot Kristian A THsu Chiao-PengNast-Kolb TimonNeumann Lukas JFässler ReinhardBausch Andreas R - Protein condensates assemble actin filaments into diverse architectures, reminiscent of filopodia and stress fibers. During assembly, filament nucleation and elongation compete for a shared pool of actin monomers. Here we show that a balance between these processes is required to deform condensates of VASP, an actin polymerase, into high aspect ratio structures. Adding magnesium, which promotes filament nucleation, enhanced condensate deformation, while adding profilin, which favors elongation over nucleation, produced ring-like filament bundles that failed to deform condensates. Computational modeling predicted that a collection of short filaments would be more efficient at deforming condensates compared to a few long filaments. To test this prediction, filament capping protein was used to inhibit growth of long filaments. The resulting set of shorter filaments regained the ability to deform condensates, illustrating the importance of a balance between filament nucleation and elongation. More broadly, these findings illustrate how protein condensates balance actin nucleation, elongation, and bundling to direct the assembly of diverse cytoskeletal architectures. - Source: PubMed
Publication date: 2026/05/08
Walker CalebMansour DanielEffiong Unyime MJordan DominiqueWang LipingLafer Eileen MAlvarado JoséBelardi BrianRangamani PadminiStachowiak Jeanne C