Ask about this productRelated genes to: LIMK1 antibody
- Gene:
- LIMK1 NIH gene
- Name:
- LIM domain kinase 1
- Previous symbol:
- -
- Synonyms:
- LIMK
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1996-03-14
- Date modifiied:
- 2015-09-03
Related products to: LIMK1 antibody
Related articles to: LIMK1 antibody
- Decidualization is essential for embryo implantation and maintenance of pregnancy, during which quiescent endometrial stromal fibroblasts proliferate and differentiate into decidual stromal cells. Emerging evidence indicates that epigenetic regulators, including histone modifications, play critical roles in uterine receptivity, implantation, and stromal cell decidualization. Our previous study demonstrated that loss of histone deacetylase 3 (HDAC3) impairs endometrial receptivity and decidualization, resulting in female infertility. However, the genome-wide transcriptomic alterations responsible for defective decidualization in loss of HDAC3 remain unclear. In this study, uterine-specific Hdac3 knockout (PgrHdac3; Hdac3) mice exhibited decidual defects following 3 days of artificial decidualization. RNA sequencing analysis of uteri from control and Hdac3 mice revealed widespread dysregulation of genes and pathways associated with decidualization. Pathway analysis identified significant alterations in RHOA, AMPK-NOTCH1-HEY1, and oxidative stress-induced senescence signaling, implicating dysregulation of cytoskeletal remodeling, cellular metabolism, and oxidative stress responses in the HDAC3-mediated decidual response. Notably, expression of Limk1, Prkag1, and Cbx2 for key regulators of these pathways was significantly reduced in Hdac3 mice compared with controls. These findings demonstrate that HDAC3 is a key regulator of the transcriptional and signaling networks required for successful decidualization. Collectively, our study provides a comprehensive transcriptomic profile of HDAC3-deficient uteri and uncovers key molecular mechanisms underlying impaired decidualization, thereby advancing our understanding of uterine function and pregnancy establishment. - Source: PubMed
Nguyen Loan Thi KimTran Dinh NamNahar ShamsunKim Tae HoonJeong Jae-WookYoo Jung-Yoon - The transcription factor Sox30 (SoxH), a conserved regulator of vertebrate spermatogenesis, remains poorly characterized in mollusks, despite emerging evidence of its potential role in sex regulation. In this study, we demonstrate that AiSoxH is a functional ortholog of vertebrate Sox30 in the hermaphroditic scallop Argopecten irradians. Developmental profiling reveals that AiSoxH expression is negligible during embryogenesis and larval stages. In adults, its expression is strictly testis-specific, confined to later developmental phases (growth and maturation stages) and localized to spermatids and spermatozoa under the control of a testis-enriched promoter. Knockdown of AiSoxH significantly disrupts spermiogenesis, leading to a reduction in mature germ cells and the downregulation of key spermiogenesis-related genes, including those encoding flagellar components, microtubule-associated proteins, and protein kinases. DNA affinity purification sequencing (DAP-seq) identifies 220 putative AiSoxH targets involved in microtubule binding, protein phosphorylation, and membrane trafficking. Dual-luciferase reporter assays confirm AiSoxH's direct activation of Limk1 and Eip74EF, two essential regulators of spermiogenesis. Collectively, our findings establish SoxH as a specific regulator of spermiogenesis, with limited evidence supporting a role in sex determination, positioning it as a potential target for fertility control in hermaphroditic scallops and possibly other mollusks. - Source: PubMed
Publication date: 2026/04/03
Zhang LijingWei HuilanYang YaxinShu YaMa XiaohuiLi GuoqingZhang XinyiCao YingHan WentaoXing QiangWang ShiBao ZhenminZhang Lingling - : Sciatic nerve injuries are among the most common classes of peripheral nerve harm and have a strong impact on quality of life, as well as a significant negative economic impact for patients, society, and governments, since they represent a frequent cause of work-related disabilities and sick leave applications. Following nerve injury, neurons, Schwann, and satellite cells undergo marked changes in phenotype, metabolic activity, neuronal survival, nervous transmission, and an exacerbated activation of the inflammatory response. Leuprolide acetate (LA), a clinically available agonist of gonadotropin-releasing hormone (GnRH), has shown clear neurotrophic properties and is considered a novel potential candidate for treating neural injuries, including sciatic nerve pathologies. This study aimed to analyze the effect of LA treatment on sensory function and dorsal root ganglia (DRG) changes in a rat sciatic nerve full-transection (SNT) model. : Variations in cold and heat sensitivity were assessed using the thermal plate test, while DRG tissue sections were examined for modifications in reactive gliosis by immunofluorescence analysis, and axonal transport using a retrograde tracer. Also, changes in the expression of pro-regenerative genes , , , , , and were quantified by qPCR. : Our results showed that LA treatment exerted a distinct neurotrophic effect, since it promoted the specific recovery of cold sensitivity, improved axonal transport, regulated the inflammatory response, and modulated the exacerbated expression of pro-regenerative genes in the SNT model. : These findings indicate that LA therapy may have the potential to improve sensory recovery in patients with sciatic nerve injuries. - Source: PubMed
Publication date: 2026/03/20
Hernández-Jasso IrmaCalderón-Vallejo DenisseÁvila-Mendoza JoséEpardo DavidBalderas-Márquez Jerusa EArámburo CarlosQuintanar J LuisMartínez-Moreno Carlos G - - Source: PubMed
Publication date: 2026/03/25
Yang ChangqingYing JianjianShi CangchangHai LinyueWang GuixinLi YingxiTian YaoHe JinxianZhu KeyunFeng Jing - Eosinophils are pro-inflammatory cells that play a central role in asthmatic inflammation. However, few studies have examined their methylation profiles in asthma, all relying on microarray-based approaches. Here, an epigenome-wide association study in 183 purified eosinophil samples from the Saguenay-Lac-Saint-Jean asthma family cohort was performed using a custom sequencing panel targeting 4,609,564 CpGs in immune regulatory regions. Two CpG sites in MAEA and SLC9A2 genes, known to be involved in immune function, were significantly associated with asthma, while five additional sites showed suggestive associations. Integration with genotype data (7,829,429 variants) and expression counts (17,513 genes) identified significant quantitative trait loci-mediated regulatory effects. Two CpG sites at Chr1:6,267,177, which is a suggestive association, and Chr2:103,279,574 were linked to expression of EFNA5, GNAQ, and LIMK1, implicating them in eosinophil-driven asthma pathogenesis. This finding offers insights into the asthma's epigenetic architecture, highlighting disease-relevant loci detectable through targeted analysis of eosinophils. - Source: PubMed
Publication date: 2026/03/18
Dionne-Gagné RébeccaMadore Anne-MarieBoucher-Lafleur Anne-MariePastinen TomiLaprise Catherine