Ask about this productRelated genes to: TPSG1 antibody
- Gene:
- TPSG1 NIH gene
- Name:
- tryptase gamma 1
- Previous symbol:
- -
- Synonyms:
- TMT, PRSS31
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-21
- Date modifiied:
- 2015-08-26
Related products to: TPSG1 antibody
Related articles to: TPSG1 antibody
- Necroptosis is considered to be a new form of programmed necrotic cell death, which is associated with metastasis, progression and prognosis of various types of tumors. However, the potential role of necroptosis-related genes (NRGs) in the triple negative breast cancer (TNBC) is unclear. - Source: PubMed
Publication date: 2022/08/19
Pu ShengyuZhou YudongXie PeilingGao XiaoqianLiu YangRen YuHe JianjunHao Na - Breast tumor stiffness, which can be objectively and noninvasively evaluated by ultrasound elastography (UE), has been useful for the differentiation of benign and malignant breast lesions and the prediction of clinical outcomes. Liquid biopsy analyses, including cell-free tumor DNA (ctDNA), exhibit great potential for personalized treatment. This study aimed to investigate the correlations between the UE and ctDNA for early breast cancer diagnosis. - Source: PubMed
Hao YiYang WeiZheng WenyiChen XiaonaWang HuiZhao LiangXu JinfengGuo Xia - Eczema herpeticum (EH) is a rare complication of atopic dermatitis (AD) caused by disseminated herpes simplex virus (HSV) infection. The role of rare and/or deleterious genetic variants in disease etiology is largely unknown. This study aimed to identify genes that harbor damaging genetic variants associated with HSV infection in AD with a history of recurrent eczema herpeticum (ADEH+). - Source: PubMed
Publication date: 2021/03/15
Bin LianghuaMalley ClaireTaylor PatriciaPreethi Boorgula MeherChavan SameerDaya MichelleMathias MalaikaShankar GautamRafaels NicholasVergara CandelariaPotee JosephCampbell MonicaHanifin Jon MSimpson EricSchneider Lynda CGallo Richard LHata TissaPaller Amy SDe Benedetto AnnaBeck Lisa AOng Peck YGuttman-Yassky EmmaRichers BrittanyBaraghoshi DavidRuczinski IngoBarnes Kathleen CLeung Donald Y MMathias Rasika A - To establish the drug-resistant cell lines of hepatocellular carcinoma (HCC) induced by sorafenib, and to screen out the high expression genes in drug-resistant cell lines of HCC induced by sorafenib, then to explore the genes related to sorafenib resistance in hepatocellular carcinoma. - Source: PubMed
Ma BTian Z HQu LLiu Y XZhang HDing H R - Mast cell tryptases have crucial roles in allergic and inflammatory diseases. The mouse tryptase genes represent a cluster of loci on chromosome 16p3.3. While their functional studies have been extensively performed, transcriptional regulation of tryptase genes is poorly understood. In this study, we examined the molecular basis of the tryptase gene expression in bone marrow-derived mast cells (BMMCs) of C57BL/6 mice and in MEDMC-BRC6 mast cells. The expression of the and genes, which reside at the 3'-end of the tryptase locus, is significantly decreased by the reduction of the GATA transcription factors GATA1 or GATA2. Chromatin immunoprecipitation assays have shown that the GATA factors bind at multiple regions within the locus, including 1.0 and 72.8 kb upstream of the gene, and that GATA1 and GATA2 facilitate each other's DNA binding activity to these regions. Deletion of the -72.8 kb region by genome editing significantly reduced the and mRNA levels in MEDMC-BRC6 cells. Furthermore, binding of CTCF and the cohesin subunit Rad21 was found upstream of the -72.8 kb region and was significantly reduced in the absence of GATA1. These results suggest that mouse tryptase gene expression is coordinately regulated by GATA1 and GATA2 in BMMCs. - Source: PubMed
Publication date: 2019/09/17
Ohneda KinukoOhmori Shin'yaYamamoto Masayuki