Ask about this productRelated genes to: TMEFF2 antibody
- Gene:
- TMEFF2 NIH gene
- Name:
- transmembrane protein with EGF like and two follistatin like domains 2
- Previous symbol:
- -
- Synonyms:
- TENB2, HPP1, TR, TPEF, CT120.2
- Chromosome:
- 2q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-02
- Date modifiied:
- 2016-01-21
Related products to: TMEFF2 antibody
Related articles to: TMEFF2 antibody
- In dairy sheep, mammary morphology-related phenotypes are crucial functional traits due to their connection to machine milking aptitude, udder health, particularly mastitis, and animal welfare. This study aimed to dissect the genetic architecture underlying 5 mammary morphology traits (Udder depth, Udder attachment, Teat placement, Teat size, and Udder shape) in Churra dairy sheep by using data generated with the Illumina OvineSNP50 BeadChip. The analyzed population, part of the Churra Dairy Selection Nucleus (ANCHE), comprised 1,680 ewes distributed across 16 half-sib families. Genome scans using linkage analysis and a GWAS detected 5 genome-wide significant QTL regions. Comparison with previously reported sheep QTL revealed no direct overlap; however, several of the identified regions coincided with QTL reported in cattle for mammary morphology and mastitis resistance traits, suggesting the possibility of conserved genetic mechanisms underlying these traits across ruminant species and further supporting the relevance and validity of the genomic regions detected in this study. Interestingly, the genome-wide significant QTL region detected on OAR13 for Teat placement showed overlapping with chromosome-wide effects on Udder shape, suggesting for this region a potential pleiotropy effect or the presence of closely linked variants affecting multiple udder traits. To further explore the genome-wide significant regions identified in this study, all genes within each region were annotated. Among the 84 annotated genes, 3 of them, NCOA3, ASS1, and TMEFF2, directly overlapped with a previously defined reference gene list for udder traits and were therefore considered direct functional candidate genes. These genes were associated with epithelial branching, extracellular matrix regulation, cytoskeletal dynamics, and signaling pathways. For the remaining annotated genes in the target regions, a prioritization analysis was performed to identify additional potential candidate genes that may be relevant to the traits under study. The results reported here offer a valuable insight into the genetic basis of udder morphology traits in dairy sheep and are a first step into the identification of genetic markers that could improve the efficiency of future genomic selection programs in dairy sheep. - Source: PubMed
Publication date: 2026/03/02
Vrcan MSuárez-Vega AMarina HDzidic AArranz J JGutiérrez-Gil B - A deep multi-omic analysis of post mortem human brains has identified a new co-expression protein network - Module 42 (M42), strongly corelated with Alzheimer's disease (AD) pathology. M42 comprises 32 transmembrane and extracellular matrix (ECM)-associated proteins, including the amyloid precursor protein (APP) and apolipoprotein E (apoE), and its members have been implicated in amyloid beta (Aβ) pathology. We systematically evaluated the Aβ-independent effects of M42 on immune function in vitro. - Source: PubMed
Ajith IshitaBakshi SouvikaMead EmmaGileadi OpherKatis Vittorio LBrennan Paul E Gospodinova Katerina O - Pancreatic cancer is a common malignant tumor. We focused on exploring the function of miR-641 in stem cell characteristics for pancreatic cancer cells. - Source: PubMed
Publication date: 2026/02/07
Han HongchaoWang Aikun - Benign prostatic hyperplasia (BPH) is a prevalent pathological condition and a significant, though not exclusive, contributor to lower urinary tract symptoms (LUTS) in aging males. Despite decades of intensive research, the molecular mechanisms underlying BPH remain elusive. We investigated the potential functional roles of TMEFF2 and its underlying mechanisms in prostatic hyperplasia. - Source: PubMed
Publication date: 2025/08/06
Li MingzhouLiu DaoquanBai YutingZeng ChengyanLiu Jianmin - Toxic chemicals and epigenetic biomarkers associated with cancer have been used successfully in clinical diagnostic screening of feces and urine from individuals, but they have been underutilized in a global setting. We analyzed peer-reviewed literature to achieve the following: (i) compile epigenetic biomarkers of disease, (ii) explore whether research locations are geographically aligned with disease hotspots, and (iii) determine the potential for tracking disease-associated epigenetic biomarkers. Studies ( = 1145) of epigenetic biomarkers ( = 146) in urine and feces from individuals have established notable diagnostic potential for detecting and tracking primarily gastric and urinary cancers. Panels with the highest sensitivity and specificity reported more than once were SEPT9 (78% and 93%, respectively) and the binary biomarker combinations GDF15, TMEFF2, and VIM (93% and 95%), NDRG4 and BMP3 (98% and 90%), and TWIST1 and NID2 (76% and 79%). Screening for epigenetic biomarkers has focused on biospecimens from the U.S., Europe, and East Asia, whereas data are limited in regions with similar/higher disease incidence rates (i.e., data for New Zealand, Japan, and Australia for colorectal cancer). The epigenetic markers discussed here may aid in the future monitoring of multiple cancers from individual- to population-level scales by leveraging the emerging science of wastewater-based epidemiology (WBE). - Source: PubMed
Publication date: 2025/03/17
Newell Melanie EngstromBabbrah AyeshaAravindan AnumithaRathnam RajHalden Rolf U