Ask about this productRelated genes to: SERPINE2 antibody
- Gene:
- SERPINE2 NIH gene
- Name:
- serpin family E member 2
- Previous symbol:
- PI7
- Synonyms:
- PN1, GDN, PNI, nexin
- Chromosome:
- 2q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-09-01
- Date modifiied:
- 2016-04-06
Related products to: SERPINE2 antibody
Related articles to: SERPINE2 antibody
- The recent inclusion of the Merlin clinicopathologic-gene expression profile (CP-GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents an important milestone in the clinical integration of molecular testing for cutaneous melanoma. Unlike earlier melanoma gene expression profile (GEP) assays, which focused primarily on prognostic risk stratification, CP-GEP was specifically developed to predict sentinel lymph node (SLN) metastasis risk by identifying early metastatic competence within primary melanomas, with additional prognostic utility. This review discusses the biological evidence supporting CP-GEP and examines how unbiased transcriptomic discovery converged with established insights from cancer cell biology, integrin signaling, focal adhesions, and extracellular matrix (ECM) remodeling to shape its conceptual framework. We further discuss how CP-GEP captures a transformation-associated biological state centered on an integrin- and TGF-β-dependent signaling axis (ITGB3, TGFBR1) that promotes pericellular proteolysis and ECM remodeling (PLAT, SERPINE2, LOXL4), inflammatory and angiogenic signaling (CXCL8, GDF15), and melanocytic lineage identity (MLANA). Collectively, these genes identify a dissemination-competent phenotype that is detectable within primary tumors before clinically apparent metastasis. Overall, the biological framework supporting CP-GEP reinforces the concept that altered adhesion signaling and ECM remodeling are central drivers of early melanoma metastasis and represent clinically actionable biomarkers for individualized melanoma management. - Source: PubMed
Publication date: 2026/08/03
Jing Frank ZMeves Alexander - Glioblastoma (GBM) is an aggressive brain tumor characterized by rapid growth and infiltration. New therapies are desperately needed to improve GBM patient outcomes. Intra-tumoral heterogeneity is a common driver of failure for novel GBM treatments, and many preclinical studies rely on cell lines established from the tumor core. As a result, they fail to characterize the infiltrative tumor cells, which remain post-surgery and ultimately drive tumor recurrence. - Source: PubMed
Publication date: 2026/07/10
Porter HarryMulhall KayleyShah MariaVinohar Jeffy JosephKaradimas Konstantinos-PanagiotisMistry ShaylenDeacon SimonHaque FarhanaBakker EmyrBoocock David JCoveney ClareLayfield RobertRahman RumanMcCrorie Phoebe - Acral melanoma (AM) is characterized by a high incidence of distant metastasis. Although the genomic characterization of AM has been explored, the landscape of AM in different stages is still a critical factor to be researched. We performed single-nucleus RNA sequencing analysis in three nevi, seven primary AM, four skin metastases, and three lymph node metastasis specimens. Cell subpopulations were characterized. The identified marker was verified in clinical samples, and the function was further validated by in vitro and in vivo experiments through establishing a knockdown cell line. A total of 13 types of cells were identified from 17 samples. Ten cancer cell subtypes were profiled through comprehensive analysis. Analysis identified Cancer cells_TGFBI to be the potential progressive subpopulation, and SERPINE2 was the top differentially expressed gene. SERPINE2 knockdown significantly suppressed melanoma cell growth and invasion, and downregulated the EMT pathway. Cancer-associated fibroblast (CAF) had the second largest number of cells. A new cluster, Fibroblast_TNXB, was identified and had potential correlation with melanocyte differentiation and development. The above findings demonstrated the tumor heterogeneity of AM. SERPINE2 had the potential to be a therapeutic target for melanoma, and Fibroblast_TNXB may link to melanocytic differentiation, highlighting new microenvironmental crosstalk in AM. - Source: PubMed
Publication date: 2026/07/17
Wu MinliangChen KexinWang YuchongXu JianguoLi AngJin ChaoyingZhu JiXue Chunyu - Immune checkpoint inhibitors (ICIs) have extended survival in patients with non-small cell lung cancer (NSCLC) but their therapeutic benefit is limited to a proportion of patients. Predictive biomarkers based on tissue of origin of the tumor have their limitations, and thus there is a need for solid and minimally invasive predictive biomarkers. Our aim was to investigate serum proteomics via liquid biopsy for biomarker discovery. - Source: PubMed
Publication date: 2026/06/15
Ma YimingGao YuanShao ChangjianWei KaiqiWang WenchenShao QiongjieJiang Tao - The aim of this study was to investigate the immunohistochemical expression of METTL3 and SERPINE2 in urothelial carcinoma and to assess their individual and combined associations with clinicopathological features and possible correlation. This study included 126 cases of urothelial carcinoma. Immunohistochemical staining was used to evaluate METTL3 and SERPINE2 expression in tumour tissues. Clinico- pathological data including age, sex, bilharziasis, tumour grade and stage, lymph node status, lymphovascular invasion, soft tissue surgical margins, and tumour- infiltrating lymphocytes (TIL) were collected. Statistical analysis was performed to determine associations between marker expression and clinicopathological parameters. High nuclear METTL3 expression was significantly associated with a higher tumour grade, advanced stage, increased TIL, and lymphovascular invasion, with no significant association with age, sex, bilharziasis, nodal stage, or surgical margins. High cytoplasmic SERPINE2 expression was significantly associated with an advanced stage, lymph node metastasis, and positive soft tissue margins, while no association was found with age, sex, bilharziasis, grade, TIL, or lymphovascular invasion. Combined high METTL3/high SERPINE2 expression correlated significantly with a high grade, advanced tumour and nodal stages, low TIL, and positive surgical margins, indicating a more aggressive tumour phenotype. METTL3 and SERPINE2 are associated with adverse pathological features in urothelial carcinoma, and their combined overexpression may serve as a potential prognostic biomarker. - Source: PubMed
Attya Mina EzzatSayed Hany Yousry