Ask about this productRelated genes to: SCHIP1 antibody
- Gene:
- SCHIP1 NIH gene
- Name:
- schwannomin interacting protein 1
- Previous symbol:
- -
- Synonyms:
- SCHIP-1
- Chromosome:
- 3q25.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-05-09
- Date modifiied:
- 2016-10-24
Related products to: SCHIP1 antibody
Related articles to: SCHIP1 antibody
- Dysplastic nodules (DN) are precursors to cirrhosis-associated malignancy, and the HBV DNA integration in the human genome plays a critical role in tumorigenesis. However, the precise relationship between DN and HBV integration remains unclear. We performed HBV-capture sequencing on 19 cirrhosis patients with HBV infection (DN, 10; RN, 9), out of which 10 subjects (DN, 9; RN, 1) underwent RNA sequencing. In total, 1936 and 1450 HBV integration sites were identified in the DN and RN samples, respectively. The number of HBV integration sites in DN correlated with nodule size. Breakpoints in HBV genome were concentrated within 100 bps toward the 5' or 3' end of involved HBV genes. Furthermore, integration numbers also positively correlated with number of point mutations in DN samples. We identified 53 and 29 recurrent genes containing HBV integrations in ≥ 2 samples in DN and RN samples, respectively. Higher clonality was observed for HBV integrations in recurrent genes than other HBV-integrated genes. The HBV integrations in recurrent genes were predominantly located in intron regions. Notably, among those recurrently HBV-integrated genes in DN samples, SCHIP1, ZDHHC14, YPEL2, RABGAP1L, and SOX5 displayed significant expression alterations. Moreover, clinical indicators revealed significant prolongation of prothrombin time in two DN patients with HBV integrations in SCHIP1 and ZDHHC14. As a new insight regarding HBV integrations in DN stage, our findings suggest a possible role of HBV integration in the transformation of DN to early-stage liver cancer by affecting the expression of key genes. - Source: PubMed
Zeng XiLiu HuiXu ZheqiRao XinjieWang YuyouyePeng FangDong WeiWang ZiyingWang ZhenguangGu XingLiu FuchenLi GuoliangZhou WeipingZhao Linghao - Dysplastic nodules (DN) are precursors to cirrhosis-associated malignancy, and the HBV DNA integration in the human genome plays a critical role in tumorigenesis. However, the precise relationship between DN and HBV integration remains unclear. We performed HBV-capture sequencing on 19 cirrhosis patients with HBV infection (DN, 10; RN, 9), out of which 10 subjects (DN, 9; RN, 1) underwent RNA sequencing. We performed HBV-capture sequencing on 19 cirrhosis patients with HBV infection (DN, 10; RN, 9), out of which 10 subjects (DN, 9; RN, 1) underwent RNA sequencing. 1936 and 1450 HBV integration sites were identified in the DN and RN samples, respectively. The number of HBV integration sites in DN correlated with nodule size. Breakpoints in HBV genome were concentrated within 100 bps towards the 5' or 3' end of involved HBV genes. Furthermore, integration numbers also positively correlated with number of point mutations in DN samples. We identified 53 and 29 recurrent genes containing HBV integrations in >=2 samples in DN and RN samples, respectively. Higher clonality was observed for HBV integrations in recurrent genes than other HBV-integrated genes. The HBV integrations in recurrent genes were predominantly located in intron regions. Notably, among those recurrently HBV-integrated genes in DN samples, SCHIP1, ZDHHC14, YPEL2, RABGAP1L, and SOX5 displayed significant expression alterations. Moreover, clinical indicators revealed significant prolongation of prothrombin time in two DN patients with HBV integrations in SCHIP1 and ZDHHC14. As a new insight regarding HBV integrations in DN stage, our findings suggest a possible role of HBV integration in the transformation of DN to early-stage liver cancer by affecting the expression of key genes. - Source: PubMed
Zeng XiLiu HuiXu ZheqiRao XinjieWang YuyouyePeng FangDong WeiWang ZiyingWang ZhenguangGu XingLiu FuchenLi GuoliangZhou WeipingZhao Linghao - Schip1 serves as a pivotal regulatory factor in both the Hippo pathway and the PDGFB signaling pathway, which are significant in the pathogenesis of osteoporosis. However, the role of Schip1 in osteoporosis remains to be elucidated. In this study, we demonstrated for the first time that Schip1 acted as a positive regulator in osteoclastogenesis. We observed a significant upregulation of Schip1 expression during Rankl-induced osteoclast differentiation, and the suppression of Schip1 expression notably reduced Rankl-induced osteoclast formation. Functionally, Schip1 interacted with Taok1 to activate the p38 MAPK signaling pathway, which promoted osteoclast differentiation. Genetic ablation of Schip1 in mice resulted in pronounced osteosclerosis compared to wild-type controls. Furthermore, mice with deletion of Schip1 exhibited significantly mitigated osteoporosis following ovariectomy. Collectively, our findings establish Schip1 as a regulator of osteoclast differentiation and suggest its potential as a therapeutic target for osteoporosis. - Source: PubMed
Publication date: 2025/07/07
Liu FuruiTian MuhangWang SenGuo LeiChen Fangjing - In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: like, and that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan. - Source: PubMed
Publication date: 2024/12/16
Korec EvženUngrová LenkaKalvas JosefHejnar Jiří - Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain unclear. - Source: PubMed
Publication date: 2023/11/20
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