Ask about this productRelated genes to: PSMB9 antibody
- Gene:
- PSMB9 NIH gene
- Name:
- proteasome subunit beta 9
- Previous symbol:
- LMP2
- Synonyms:
- RING12, beta1i, PSMB6i
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1991-12-18
- Date modifiied:
- 2016-10-05
Related products to: PSMB9 antibody
Related articles to: PSMB9 antibody
- Understanding the molecular mechanisms of host-parasite interaction remains a central challenge in fish immunology. This study presents the first transcriptomic analysis of the head kidney-a primary immune organ in teleost fish - in the Baikal omul (Coregonus migratorius) naturally infected with plerocercoids of the cestode Dibothriocephalus dendriticus. RNA-Seq data were generated and used to perform a de novo assembly of head kidney transcriptomes from infected and uninfected fish, followed by differential gene expression analysis. We identified a complex immune response characterized by the activation of pattern recognition receptors (PRRs), including C-type lectin receptors (CLRs), NOD-like receptors (NLRs), and Toll-like receptors (TLRs). KEGG pathway enrichment and DGE analysis revealed significant upregulation of pro-inflammatory signaling cascades (e.g., IKBKE, IRF5), antigen presentation components (e.g., PSMB9, MR1), as well as adapter and immunoregulatory molecules (e.g., GRAP2, TMIGD2, CD22). Concurrently, a selective down-regulation of several effector genes of both adaptive and innate immunity (e.g., IGHV, VLIG1, FCGR1A) was observed, indicating a suppression of energetically costly immune programs. GO analysis revealed significant enrichment of processes related to innate immune response, negative regulation of transcription and cell proliferation, as well as proteostasis control systems, accompanied by remodeling of the cellular component profile. These data suggest a strategy of controlled immune activation in C. migratorius, aimed at establishing long-term equilibrium with the parasite while minimizing energetic costs and immunopathology. This study expands fundamental knowledge of coregonid immunology and provides a foundation for investigating the molecular mechanisms of resistance to tissue-dwelling helminth infections. - Source: PubMed
Publication date: 2026/04/25
Evgenievna Mazur OlgaKutyrev Ivan AlexandrovichSidorova Tuyana ValeryevnaSukhanova Lubov Vasilyevna - 2',2',4',4'-Tetrabromodiphenyl ether (BDE-47), the most widespread congener of polybrominated diphenyl ethers, has attracted considerable attention due to its environmental persistence and extensive use. Although epidemiological data associate BDE-47 exposure with increased cancer risk, its role in bladder cancer (BC) remains insufficiently characterized. We found that BDE-47 at a physiologically relevant concentration (0.1 μM, comparable to human exposure levels) enhanced malignant phenotypes of BC cells in vitro. A total of 229 candidate genes were uncovered at both bulk and single-cell transcriptomic levels through weighted gene co-expression network analysis and its single-cell extension. Functional enrichment revealed prominent involvement in inflammatory regulation, extracellular matrix remodeling, and lipid metabolism pathways, further supported by transcriptome analysis of BDE-47-treated BC cells. Protein-protein interaction network construction combined with machine learning identified eight hub genes (ACSL4, IFIH1, JAK2, PSMB9, ACSL5, SOCS3, SREBF1, and JUN) as core targets of BDE-47-driven BC progression. Molecular docking suggested favorable predicted interactions between BDE-47 and these targets. A nomogram was constructed within the TCGA-BLCA cohort to visualize the prognostic model. Collectively, our findings provide a preliminary delineation of candidate targets and pathways potentially involved in BDE-47-associated bladder cancer progression, thereby offering a rationale for further mechanistic investigations. - Source: PubMed
Publication date: 2026/04/23
Sun MinghuiHu DichaoLi TongjieChen ZepingCong BoXi ZhenWang YongchenGuo RulinZhuo JianWu WenboLiu Haitao - Cutaneous melanoma (CM) is an aggressive cancer where early intervention is crucial, but the prognostic role and mechanisms of ubiquitination-related genes (URGs) in immune regulation remain unclear. This study aimed to develop a URG-based prognostic signature and explore its relationship with immune modulation in CM. We integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data, identifying prognostic URGs through univariate and multivariate Cox regression. A six-gene signature (UBE2L6, SPSB1, PSMB9, PSMB10, RNF213 and ATXN3) was established and validated. The signature effectively stratified patients into high- and low-risk groups, with significant survival differences. Pathway analysis revealed immune-related processes, such as 'cytokine-cytokine receptor interaction' and 'antigen processing and presentation', enriched in the low-risk group. Immune cell infiltration analysis demonstrated significant differences in the abundance of 12 immune cell types between risk groups. Notably, PSMB9 expression was positively correlated with CD8 T cell abundance (r = 0.64, p < 0.05). scRNA-seq analysis highlighted T cells as a key cell type, with all six prognostic genes showing dynamic expression changes during T cell differentiation. Our findings suggest that URGs influence CM prognosis by modulating the immune microenvironment, offering new insights for immunotherapeutic strategies. - Source: PubMed
Publication date: 2026/04/21
Lu JianpingLin ChengGao WeiLiu JieLin YucaiChen YuXiong Jiani - Diabetic kidney disease (DKD) is characterized by chronic inflammation and immune dysregulation. Multiple programmed cell death pathways contribute to tubulointerstitial injury, but their perturbations, crosstalk, and integrative impact in DKD remain unclear. PANoptosis-a coordinated program integrating pyroptosis, apoptosis, and necroptosis-has emerged as a key mechanism in inflammatory disorders, yet its role in DKD is not defined. - Source: PubMed
Publication date: 2026/03/09
Chen YintongYuan FeifeiLi ShengyuanLiu LerongPeng XuankunZeng XiangrongChen SiyongLiu NianpingZhao Tongfeng - Osteoarthritis (OA) is a degenerative disease with incompletely understood mechanisms. The proteasome subunit PSMB9 has been implicated in immune regulation, but its specific role in OA pathogenesis remains unclear. This study aimed to investigate whether PSMB9 mediates IL-1β-induced chondrocyte injury by activating the NF-κB pathway through promoting IκBα degradation, and to explore the regulatory relationship between IL-6 and PSMB9 in OA progression. - Source: PubMed
Publication date: 2026/03/14
Zhao LianhuiOu JianliangBian SijieWu ZhangweiWang XuShi ShuoLiu XinBo KaidaShi DaizhiChang Jun