Ask about this productRelated genes to: PPARA antibody
- Gene:
- PPARA NIH gene
- Name:
- peroxisome proliferator activated receptor alpha
- Previous symbol:
- PPAR
- Synonyms:
- hPPAR, NR1C1
- Chromosome:
- 22q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-01
- Date modifiied:
- 2016-10-05
Related products to: PPARA antibody
Related articles to: PPARA antibody
- Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear. Single-nucleus transcriptomics of mouse liver 48 h after 70% PHx revealed that EGFR-FOXM1 signalling drives mitotic entry while simultaneously suppressing PPARα-ACSL1-mediated lipid catabolism. Consequently, triglycerides and free fatty acids accumulate in regenerating tissue. Activating PPARα with the agonist Wy-14643 released this metabolic brake, accelerated hepatocyte proliferation via HIF1α-FOXM1, and improved post-PHx recovery. These data identify lipid-metabolic reprogramming as an EGFR-dependent collateral effect that can be pharmacologically reversed to enhance liver regeneration in surgical patients, offering a readily translatable strategy to reduce post-operative liver failure and shorten hospital stay after major hepatectomy. - Source: PubMed
Publication date: 2026/04/22
Hu YueleiSong ShifeiWang RuilinAn NiDiao JinmeiChen YuguoLiu JuanLv Guoyue - High altitude exposes humans to hypobaric hypoxia and poses a significant challenge for human performance and survival. Humans have adapted to the chronic hypoixa of high altitude in several geographical locations and nevertheless, the fundamental questions regarding the functional links between those adoptive unique phenotypic attributes and the associated cellular and molecular signaling mechanisms remains unanswered. The high-altitude acclimatization and adaptation responses are primarily orchestrated by hypoxia inducible factor (HIF). However, some HIF-independent response pathways exists and act either in coordination and/or in parallel to HIF to mediate the physiological response of hypoxia. Recently, several multi-omic analysis studies demonstrated crucial oxygen homeostatic and metabolic signaling pathways in hypoxia including members of nuclear receptor (NR's) superfamily like LXR's, RXR's, ER's and PPARA's. Since acclimatization and adaptation to high altitude confers several benefits for the prevention of various high altitude illnesses, the cellular and molecular signaling mechanisms underlying oxygen homeostasis during acute and prolonged high altitude exposure becomes an attractive avenue for understanding the physiology of adaptation and pathophysiology of mal-adaptation. Members of NR's are of particular interest owing to their involvement in multiple physiological functions and their possible role in epigenetic regulation due to the presence of well defined DNA and ligand binding domains. In this review, we summarize the current understanding of the involvement of NR's in regulation of physiological responses hypoxia and how they may contribute for high altitude adaptation. Additionally, we have made an effort to draw attention to the connection between NRs and EVs. - Source: PubMed
Publication date: 2026/04/21
Huirem Rohit SinghReddy M Kumar Prasanna - The differences in egg production performance among hens are closely linked to the efficiency of follicle selection, which is characterized by granulosa cell differentiation and progesterone production. In this study, by integrating ATAC-seq and mRNA-seq analyses on granulosa cells from pre-hierarchical (Pre-GCs) and hierarchical (Post-GCs) follicles, we set out to identify key regulatory factors involved in chicken follicle selection. - Source: PubMed
Publication date: 2026/04/17
Li DandanQi ChaoSun YiKang LiWei QingqingJiang Yunliang - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common progressive condition associated with chronic liver diseases caused by lipid dyshomeostasis, which has become a global pandemic. The incomplete understanding of its mechanisms has resulted in a lack of clinically effective therapeutic options. Miao medicine Jinshanxiaoke Granules (JXKG), a formula used for treating metabolic disorders, is rooted in the traditional Chinese medicine theory of "dampness-heat stasis". However, its specific efficacy and underlying mechanism against MASLD have yet to be elucidated. - Source: PubMed
Publication date: 2026/04/15
Wang HongjiWu XuemeiMou YuWang QianjunWu XiangqunRao QingShi YingpingLiu XiangZheng XiuyanYuan ChunmaoHuang Lei - We previously demonstrated that a clinically relevant dose of pemafibrate (PEM), a selective peroxisome proliferator-activated receptor α (PPARα) modulator (SPPARMα), reduces serum triglyceride (TG) levels in mice via hepatic PPARα activation. However, the specific contribution of hepatocyte PPARα remains unclear. To address this, male -floxed () and hepatocyte-specific -disrupted () mice were fed a diet with or without a clinically relevant dose of PEM (0.00005%) for four weeks. In mice, PEM significantly reduced circulating TG and non-esterified fatty acid levels by enhancing hepatic fatty acid uptake and β-oxidation. In contrast, these effects were absent in mice. Notably, PEM did not activate PPARα in extrahepatic tissues, including white/brown adipose tissue, kidney, and skeletal muscle in either genotype. These findings underscore the essential role of hepatocyte PPARα in mediating the pharmacological effects of PEM at clinically relevant doses. - Source: PubMed
Publication date: 2026/04/06
Zhang ZheZhang XuguangQian ChufangDiao PanNakajima TakeroKimura TakefumiGonzalez Frank JTanaka Naoki