Ask about this productRelated genes to: PPARA antibody
- Gene:
- PPARA NIH gene
- Name:
- peroxisome proliferator activated receptor alpha
- Previous symbol:
- PPAR
- Synonyms:
- hPPAR, NR1C1
- Chromosome:
- 22q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-01
- Date modifiied:
- 2016-10-05
Related products to: PPARA antibody
Related articles to: PPARA antibody
- Gut microbial dysbiosis has been implicated in metabolic dysfunction-associated steatotic liver disease (MASLD) and diabetes, but the metabolic effects of candidate probiotic strains across this disease continuum remain incompletely understood. Based on the validation of disease-associated microbial patterns in a clinical cohort, as selected as a candidate strain, and its effects were systematically investigated across multiple complementary models, including Western diet, fructose-palmitate-cholesterol diet, high-fat diet, and leptin-deficient ob/ob mice. supplementation attenuated hepatic steatosis and inflammatory injury in multiple complementary models and improved glucose tolerance in ob/ob mice. These effects were accompanied by reduced hepatic expression of pro-inflammatory cytokines, changes in AMPK-associated signaling, decreased expression of lipogenic ( and ) and gluconeogenic ( and ) genes, and increased expression, suggesting coordinated regulation of glucose and lipid metabolism. Transcriptomic profiling further indicated that influenced broader metabolic networks, including altered expression of and enrichment of pathways related to nutrient sensing and metabolic regulation. In addition, supplementation altered gut microbial community structure in mouse models, while human cohort analyzes revealed context-dependent microbial patterns involving , , and butyrate-producing Firmicutes across metabolic disease states. Collectively, these findings suggest that may improve metabolic dysfunction through coordinated hepatic metabolic regulation and gut microbial modulation, supporting its potential as a probiotic candidate for MASLD and diabetes-associated metabolic disease. - Source: PubMed
Publication date: 2026/09/19
Park Hee JinPark In GyuPark Jeong HaPark Hyun JoonJung Jin JuHan Sang HakSuk Ki Tae - Cage rearing of laying ducks offers advantages for intensive production, but the early period after cage transfer can elicit marked stress responses. This study investigated intestinal morphology, antioxidant status, DNA oxidative damage, autophagy-related changes, and apoptosis during the first 10 days after cage transfer in Shaoxing laying ducks. A total of 120 100-day-old female Shaoxing ducks were assigned to floor-rearing (FR) or cage-rearing (CR) treatments. In vivo, CR produced time- and tissue-dependent intestinal changes. On day 5, villus height and crypt depth were reduced in the duodenum, villus height and the villus height-to-crypt depth ratio were reduced in the jejunum, and crypt depth was increased in the ileum (P < 0.05). Antioxidant enzyme activities were altered at selected time points, intestinal MDA was increased on day 5, and serum 8-OHdG was increased on day 5 (P < 0.05). Jejunal ROS accumulation, autophagosome formation, and an increased LC3-II/LC3-I ratio were observed in CR ducks. TUNEL staining showed increased apoptosis, and PARP-1 protein abundance was significantly increased on day 5 (P < 0.05), whereas Caspase-3 showed an upward trend without statistical significance. Transcriptomic analysis identified differential expression of genes including CAT, BNIP3, PPARA, TLR4, and NFKB1 and enrichment of pathways including AGE-RAGE and Toll-like receptor signaling. In vitro, H₂O₂ exposure reproduced selected oxidative-stress-, autophagy-related-, and apoptosis-associated changes. Together, these findings show that early cage transfer is associated with intestinal oxidative injury accompanied by autophagy-related and apoptosis-associated changes in laying ducks. - Source: PubMed
Publication date: 2026/08/25
Zhao TianhaoFeng SiyuSun HanxueZeng TaoChen LiXu WenwuGu TiantianRen JindongSu JiayiLi RongyangLu LiZhiTian Yong - Bupleuri Radix (Chaihu) and Aurantii Fructus Immaturus (Zhishi) is a classic herb pair from Si-Ni-San. In traditional Chinese medicine theory, they regulate liver-spleen qi movement through a "one ascending, one descending" dynamic, and are used for syndromes of liver depression and spleen deficiency with phlegm-stasis intermingling. This syndrome pattern closely mirrors the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying the anti-MAFLD effect of this herb pair remain unclear. - Source: PubMed
Publication date: 2026/09/11
Lu JiabaoLi JianchaoYin PeiyiHuang NanaSun Rong - Mitochondrial DNA (mtDNA) polymorphisms have been associated with production traits in farm animals, including backfat thickness in pigs, yet direct in vivo evidence establishing a causal link between specific mtDNA haplotypes and fat deposition remains limited. In this study, we generated transmitochondrial pigs (mitopigs) by combining the Dapulian nuclear genome with Wuzhishan mtDNA via somatic cell nuclear transfer, introducing 23 mtDNA mutations relative to controls. Mitopigs exhibited significantly increased backfat thickness at 5 months, a difference that persisted in their offspring, without significant differences in body weight, body size, or litter size. Fibroblasts derived from mitopigs exhibited reduced mtDNA copy numbers, decreased expression of mitochondrial biogenesis genes (PPARA, PPARGC1A, RRM2B, and LRPPRC), impaired mitochondrial respiration, elevated reactive oxygen species (ROS), and upregulated adipogenic transcription factors (CEBPA, CEBPB, and PPARG). Consistent with these fibroblast findings, backfat tissue of mitopigs showed corresponding upregulation of adipogenic transcription factors and downregulation of mitochondrial biogenesis genes. Integrated transcriptomic and whole-genome bisulfite sequencing (WGBS) analyses revealed nuclear transcriptional reprogramming that was closely associated with differential DNA methylation, predominantly affecting mitochondrial function and lipid metabolism pathways. Mitopig fibroblasts also showed a pro-inflammatory response to lipopolysaccharide stimulation, with elevated expression of IL-12, NOS2, RELA, and TNF-α. Our findings provide direct in vivo evidence that mtDNA variants regulate adiposity in pigs through mitochondrial dysfunction, oxidative stress, and nuclear epigenetic modulation, highlighting the potential for incorporating mtDNA haplotype information into pig breeding programs as a complementary strategy to nuclear genomic selection. - Source: PubMed
Publication date: 2026/09/05
Liu HaoJiang YunliangShi WenshuYan ChaoOuyang ZhaochaoZhang XinGuo YanshunGuo ZhongjuLi QiuyanZhao Xingbo - is an edible medicinal fungus with potential metabolic benefits, but its effects on type 2 diabetes mellitus accompanied by hyperlipidaemia (T2DM-HLP) remain incompletely understood. This study evaluated the effects of orally administered ethanol extract (EAE; 2.0 g kg) and cordycepin (50 or 100 mg kg) in a T2DM-HLP mouse model over 6 weeks. Metabolic indices, serum transaminases, colon and liver histology, gut bacterial and fungal communities, serum metabolites, and FXR/TGR5-related molecular markers were assessed. Compared with the model group, EAE and 50 mg kg cordycepin reduced serum lipid and transaminase levels to varying degrees and were associated with downward shifts in fasting blood glucose and oral glucose tolerance test curves. Histological alterations in the colon and liver were also less apparent in these two groups. Faecal 16S rDNA and ITS sequencing showed changes in the bacterial and fungal community structure, while untargeted serum metabolomics identified distinct metabolic profiles involving bile acids, fatty acids, amino acids, nucleotides, and redox-related metabolites. Enrichment analyses implicated bile secretion, primary bile acid biosynthesis, cholesterol metabolism, cAMP signalling, and amino acid metabolism. These changes were accompanied by increased colonic TGR5 and hepatic FXR immunoreactivity, increased hepatic , , and expression, and reduced expression. Responses to 100 mg kg cordycepin were less consistent, indicating no simple dose-dependent relationship under the present conditions. Overall, EAE and cordycepin were associated with improved metabolic status and coordinated changes in the gut microbial composition, serum metabolism, and bile acid-related molecular readouts. - Source: PubMed
Publication date: 2026/09/04
Shi HuaijieMeng YingZhang GuoyingLing Jianya