Ask about this productRelated genes to: AKT1 antibody
- Gene:
- AKT1 NIH gene
- Name:
- AKT serine/threonine kinase 1
- Previous symbol:
- -
- Synonyms:
- RAC, PKB, PRKBA, AKT
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: AKT1 antibody
Related articles to: AKT1 antibody
- Protein kinase B (AKT1) plays a critical role in neuronal development, synaptic plasticity, and cognitive function. Dysregulation of AKT1 and its associated phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway has been implicated in the pathophysiology of Autism Spectrum Disorder (ASD). However, ASD is a multifactorial disorder involving multiple signaling pathways, and PI3K/AKT/mTOR crosstalk with other neurodevelopmental pathways must also be considered. Moringa oleifera, a medicinal plant rich in bioactive phytochemicals, has attracted attention for its neuroprotective, antioxidant, and anti-inflammatory properties. The present study aims to computationally evaluate the binding potential of selected Moringa oleifera phytochemicals against AKT1 using an integrated in silico approach, thereby exploring their possible modulatory effects at the pathway level rather than direct epigenetic regulation. - Source: PubMed
Publication date: 2026/05/14
Mansoor SumreenaSaid KhalilHussain AsifGul WardaSiraj ShumailaHassan Mohamed MHamayun Muhammad - Depression is one of the most common mental disorders, and more than half of individuals with depression have reduced or discontinued antidepressant use due to side effects. Medicinal plants are safer, cheaper, and more readily available than synthetic medications. This study will employ bioinformatics to assess the impact of compounds discovered in plants used in traditional Persian medicine (TPM) on key proteins involved in depressive pathways. Compounds derived from plants used in TPM for the treatment of depression were identified and subsequently evaluated for ADME properties and toxicity. The potential target genes of these compounds, along with genes associated with depression, were identified, and the intersecting genes were selected to construct a protein-protein interaction (PPI) network. Molecular docking analysis of the plant compounds and their key target proteins was conducted, followed by the selection of the most effective compound based on molecular dynamics (MD) simulation. In this study, 23 genes were identified as target genes of the plant compounds, and 582 genes associated with depression were identified, nine of which were shared, including ABCB1, AKT1, CAT, CDH1, CYP2B6, ESR1, ESR2, PPARG, and TRPV1. The PPI network identified ABCB1, AKT1, CDH1, ESR1, and PPARG as key proteins. Among them, ABCB1 and AKT1 exhibited favorable docking energies with carnosic acid. MD simulations further revealed the stability of the ABCB1-carnosic acid and AKT1-carnosic acid complexes. Our findings indicate that carnosic acid may represent a potential therapeutic option for the treatment of depression. However, further in vivo and clinical trials are required to validate these findings. - Source: PubMed
Publication date: 2026/05/21
Rahbar AryanTabibian Seyed SoheilMadanchi HamidAhmad SajjadNaderian RamtinHemmatian NajmehHedayati Seyyed BozorgmehrHatamian MiladSanami Samira - Microplastic exposure has emerged as a growing environmental health concern, with increasing evidence suggesting potential effects on the nervous system. However, the molecular basis by which polyethylene terephthalate (PET) contributes to Alzheimer's disease (AD)-related neurotoxicity remains unclear. This study examined whether PET induces neuronal injury by activating the AKT1 signaling pathway. Network toxicology integrating PubChem, STITCH, SwissTargetPrediction, OMIM, TTD, and GeneCards was used to identify PET-associated targets relevant to AD. Core targets were analyzed with Cytoscape, followed by GO and KEGG enrichment using R and clusterProfiler. Molecular docking and molecular dynamics simulations characterized the interaction between PET and AKT1. SH-SY5Y cells were exposed to PET (100 μg/mL) for 48 h and assigned to the Control, PET, and PET + MK2206 (1 μM) groups. PET exposure reduced cell viability, increased intracellular ROS levels, and enhanced AKT phosphorylation at Ser473, while MK2206 attenuated these effects. These research results show that PET microplastics can induce neurotoxic reactions by activating the AKT1 pathway. - Source: PubMed
Publication date: 2026/05/20
Hou PengyuLi XiangYan YulinLu QinWang JingniYuan MengWang XinruiWang Xingxia - To investigate the prophylactic (co-treatment) effects of vitamin D (VD), thymoquinone (TQ), and their combination against gentamicin (GM)-induced acute kidney injury (AKI). Forty male Wistar rats were divided into five groups: negative control, GM-treated positive control (PC; 100 mg/kg/day), and three groups receiving GM simultaneously with VD (210 IU/kg/day), TQ (12.5 mg/kg/day), or both. The GM-treated rats developed classical AKI symptoms, including elevated serum creatinine and urea, altered urine parameters, abnormal renal histology, and increased renal cell apoptosis. Moreover, renal tissues from PC rats showed a marked increase of oxidative stress markers (MDA/HO/protein carbonyls) and pro-inflammatory cytokines (TNF-α/IL-1β/IL-6/IL-18/TLR2), with inhibition of antioxidants (GSH/GPx1/SOD/CAT) and interleukin-10. The expression of pathogenic mediators (NFκB-p50/iNOS/TGF-β1) was significantly upregulated, while renoprotective molecules (Nrf2/AMPK-α/AKT1/survivin) were inhibited. Both VD and TQ provided partial renal protection, with TQ showing relatively greater efficacy under the tested conditions. However, their co-administration demonstrated superior efficacy relative to both monotherapies, reflected by better restoration of renal function and histology alongside stronger reductions in oxidative stress and inflammation. This combination also resulted in a more effective downregulation of pathogenic molecules alongside enhanced expression of the renoprotective pathways. This is the first study to report a relative advantage of TQ over VD under the tested conditions and demonstrate that VD and TQ co-therapy exerted enhanced renoprotection in GM-induced AKI. These ameliorations were potentially mediated through enhanced modulation of renal oxidative stress and inflammation. However, further studies should explore VD and TQ co-therapy effects on additional pathogenic mechanisms underlying aminoglycoside-induced nephropathy. - Source: PubMed
Publication date: 2026/05/21
Refaat BassemEl-Sebaey Ahmed MKhan AnmarAlbukhari Talat ARajab BodourAlqurashi SalwaFilimban WaheedSembawa HatemMegahed AyaSindi GhadirEl-Boshy Mohamed E - The present study evaluated the anticonvulsant property of hydro-alcoholic leaf extract of Pimenta dioica (L.) Merr. (Allspice), a plant known for its diverse biological properties. Phytochemical screening and ATR-IR spectral analysis confirmed the presence of various metabolites, including flavonoids, tannins, phenolic compounds, and carbohydrates. The acute toxicity study revealed no toxic effects and/or mortality at 2000 mg/kg, suggesting a favorable safety profile of the extract. The extract was administered orally, followed by evaluation in maximal electroshock (MES) and Pentylenetetrazole (PTZ)-induced seizure models. A significant anticonvulsant effect was observed, with 83.3% protection in MES model and notably increasing latency to seizure onset in the PTZ-induced convulsions. GC-MS profiling identified 275 phytocompounds, of which 66 were selected for network pharmacological analysis. This revealed 717 overlapping targets between the selected compounds and epilepsy-related targets. Network pharmacological study suggested AKT1 as a hub gene, and the anticonvulsant effects may be mediated through multiple molecular interactions. Molecular interaction study further supported that the constituents, particularly furaneol, may modulate AKT1 activity through key residue interactions, as observed with the co-crystallized ligand. Overall, the findings support the potential of P. dioica leaf in convulsion, and further work is warranted to explore the active chemicals responsible for the observed activity. - Source: PubMed
Manal DelviSahana Saidarshan R PharnakarSandhya MahadevaswamySoham BhattacharyyaSuman ChakolakusubaMohamed Shabi MNair GouriKarthik Kumar BSundara Saravanan Kamatchi