Ask about this productRelated genes to: Rac2 antibody
- Gene:
- RAC2 NIH gene
- Name:
- Rac family small GTPase 2
- Previous symbol:
- -
- Synonyms:
- EN-7
- Chromosome:
- 22q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-05
- Date modifiied:
- 2019-04-23
Related products to: Rac2 antibody
Related articles to: Rac2 antibody
- Invasive pulmonary aspergillosis (IPA) poses a serious threat to immunocompromised hosts, with limited therapeutic options highlighting the need for novel strategies. Franch. (CCF), a traditional Chinese herb containing antimicrobial alkaloids like berberine, was investigated for its therapeutic efficacy and immunological effects in a murine IPA model. Immunosuppressed female KM mice infected with AF293 were treated with CCF or amphotericin B (AmB). CCF significantly improved survival, reduced fungal burden, and alleviated lung pathology, without inducing hepatotoxicity or nephrotoxicity. Transcriptomic profiling revealed a time-dependent immune response. Complement-related pathways were enriched at 2 days post-infection, whereas neutrophil recruitment and NET-related pathways became more prominent by day 4. Hub gene analysis identified Syk, Rac2, Ncf1, and Cybb as key nodes associated with the NADPH oxidase complex. Western blot and inhibitor experiments further supported the involvement of this pathway in CCF-mediated protection. Additionally, 16S rDNA sequencing indicated enrichment of species in the gut microbiota of CCF-treated mice, which was positively correlated with the expression of NADPH oxidase-related genes, suggesting a potential gut-lung association. In conclusion, these findings support the antifungal efficacy of CCF in IPA and suggest that its protective effects may involve coordinated changes in complement-related responses, NADPH oxidase-associated neutrophil activity, and gut microbiota composition. - Source: PubMed
Publication date: 2026/04/20
Jiang ZhuqiaoZhou LingmeiWang JinpingSun HaoCai LiwenYin HanqiZhu HuiLi MingWang Zhuoya - Rac2, a member of the Rho family of small GTPases, is a fundamental regulator of essential cellular processes. Pathogenic substitutions near and within the Switch II region, specifically D57N and E62K, have been implicated in oncogenesis and immunodeficiency. Despite their proximity, D57N is characterized as a loss-of-function mutation, while E62K is a constitutively active, gain-of-function mutation. In this study, we addressed several critical questions: (i) the structural basis of their altered cellular functions, (ii) how these variants rearrange the conformational ensemble, and (iii) the subsequent impact on cellular signaling networks. Using molecular dynamics (MD) simulations, we characterized the conformational dynamics of these Rac2 variants in GDP- and GTP-bound states. Our results demonstrate that Rac2 predominantly adopts an inactive-like conformation, regardless of the bound nucleotide. GTP binding is insufficient to induce the canonical active state in this mutant. Conversely, Rac2 maintains a nucleotide-dependent toggle, appearing inactive when bound to GDP and active when bound to GTP. Additionally, we examined the assembly of these variants with the regulator p50-RhoGAP. In the wild-type complex, GAP binding facilitates a shift toward a catalytically primed transition state. In stark contrast, both the D57N and E62K complexes remain sequestered in a ground-ON state configuration, effectively trapping the GTPase and hindering GAP-mediated hydrolysis. While both Rac2 mutations result in immune system dysfunction, the underlying mechanisms are opposite: inactive vs. overactive. This work provides a high-resolution, mechanistic framework for understanding how localized perturbations in the switch loops landscape dictate systemic cellular outcomes. - Source: PubMed
Publication date: 2026/04/18
Haspel NuritJang HyunbumNussinov Ruth - The differences in egg production performance among hens are closely linked to the efficiency of follicle selection, which is characterized by granulosa cell differentiation and progesterone production. In this study, by integrating ATAC-seq and mRNA-seq analyses on granulosa cells from pre-hierarchical (Pre-GCs) and hierarchical (Post-GCs) follicles, we set out to identify key regulatory factors involved in chicken follicle selection. - Source: PubMed
Publication date: 2026/04/17
Li DandanQi ChaoSun YiKang LiWei QingqingJiang Yunliang - Colorectal cancer (CRC) remains one of the most prevalent and deadly malignancies worldwide, requiring reliable biomarkers for detection. This study profiled tRNA-derived small RNAs in CRC tissues, identifying 1051 differentially expressed tsRNAs. Notably, i-tRF-Gly-GCC was significantly elevated in CRC tissues and patient sera compared to controls, with ROC analysis yielding an AUC > 0.7, underscoring its diagnostic potential. Weighted Gene Co-expression Network Analysis (WGCNA) revealed that i-tRF-Gly-GCC's target genes, including RAC2, which was downregulated in the COAD and READ datasets, are closely related to CRC. Gene Ontology and KEGG pathway analyses further linked i-tRF-Gly-GCC to cancer-related processes. Functional experiments in HCT-116 cells demonstrated that i-tRF-Gly-GCC enhances cell proliferation and migration. These results highlight i-tRF-Gly-GCC as a novel non-invasive biomarker for CRC detection and a potential therapeutic target, advancing our understanding of tsRNA-mediated regulation in CRC and paving the way for clinical applications. - Source: PubMed
Publication date: 2026/04/10
Jiao YutingLiu AnruiLai YushanLuo WenfengZhang XiaoyingLin XiaolingKhan Tahir AliWang XiaoyunWan Yu - Glioma, especially glioblastoma (GBM), has a dismal prognosis with current therapies. In this study, we aimed to identify potential novel molecular targets for GBM by analyzing RNA sequencing. - Source: PubMed
Publication date: 2026/03/08
Ye HongxingZhang ChaoBu LinghaoXiao FengWeng YuxiangHuang KaiyuanFang ZebinFan WeijianJiang HaoZhu YuZhan RenyaZheng XiujueWang YuminPeng ZhouyingZhang Luyuan