Ask about this productRelated genes to: PPIC antibody
- Gene:
- PPIC NIH gene
- Name:
- peptidylprolyl isomerase C
- Previous symbol:
- -
- Synonyms:
- CYPC
- Chromosome:
- 5q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-18
- Date modifiied:
- 2016-01-14
Related products to: PPIC antibody
Related articles to: PPIC antibody
- Glioblastoma (GBM), especially in large or unresectable tumors, remains difficult to treat because of the lack of effective debulking, the persistence of therapy-resistant glioma stem cells (GSCs), and a profoundly immunosuppressive tumor microenvironment. Here, a locoregional hydrogel platform is developed to integrate photothermal debulking, post-ablation GSC suppression, and dendritic-cell-mediated immune activation for GBM therapy. The brain-compliant injectable hydrogel (MIN-PPIC@iGel) co-encapsulates indocyanine green/napabucasin-loaded micelles and poly(I:C)-loaded polymersomes, enabling staged local release for up to 20 days. After a single intratumoral administration followed by near-infrared irradiation, MIN-PPIC@iGel achieves surgery-mimetic photothermal cytoreduction, suppresses stem-like tumor phenotypes, and induces immunogenic cell death to generate tumor antigens and danger signals. Sustained release of poly(I:C) further activates dendritic cells and converts post-ablation tumor debris into in situ vaccines. In a large orthotopic GBM model, this single-shot locoregional therapy combined with anti-CTLA-4 renders 50% of mice tumor-free and establishes durable antitumor immunity. This work provides a material-programmed locoregional strategy for integrating local cytoreduction, stemness control, and immune activation against GBM. - Source: PubMed
Publication date: 2026/06/08
Zhang XiaoshuoCai GuangZhao SongsongQu YanyiLv RunkaiSha YongjieZhu LuyingZhong ZhiyuanMeng Fenghua - Thermo-optically tunable Mach-Zehnder interferometer (MZI) switches have been popular for building robust designs of programmable photonic integrated circuits (PPICs) for various applications. In general, microheaters integrated on both arms of the MZIs are preferred to minimize power consumption by accounting for phase errors between MZI arms arising from fabrication-induced process variabilities. However, only one of the two microheaters integrated in MZI arms is chosen to drive, for achieving desired phase imbalance with lower power consumption. Again, integrating microheaters on both arms doubles the electronic control channels and as many bond pads, posing challenges for scalability and packaging. To address this, we propose a diode-assisted microheater (DAM) architecture that enables selective driving of one of the two microheaters in an MZI without increasing the pad count or control complexity. The DAM is implemented on a standard silicon photonics technology platform and is fully compatible with foundry processes. Comprehensive electrothermal simulations and subsequent experimental results confirm the CMOS foundry fabrication feasibility of such diode-assisted microheater designs. The integrated diode design exhibits low series resistance and high breakdown voltage, ensuring efficient forward operation and negligible reverse leakage. Both the diode and microheater resistances were modelled as functions of the forward current, showing excellent agreement with experimental data. DC and AC characterizations reveal that the DAM achieves efficient thermal tuning with a total power dissipation of ∼50 mW at ±3 V and a rise/fall time of ∼20 s. The DAM's performance was validated in a 1 × 4 power splitter comprising cascaded 1 × 2 MZIs, fabricated through a commercial silicon photonics foundry. Using DAM-based tuning, we achieved precise phase correction, yielding uniform power splitting with deviations of only ±0.015 dB at 1550 nm and ±0.025 dB across a 40 nm operating wavelength bandwidth. Furthermore, by employing bipolar driving and selectively activating one of the MZI arms, we experimentally demonstrated a reduction in power consumption exceeding 50 when compared with the experimental results for the same PPIC by assuming only one microheater was integrated in MZIs. These results demonstrate that the proposed DAM architecture offers a scalable, power-efficient, and foundry-compatible solution for next-generation PPICs. - Source: PubMed
Piyush KumarPandit Pawan KumarVelamuri AshitoshGoswami ArnabViraraghavan JanakiramanDas Bijoy Krishna - Ultra-high dose-per-pulse (UHDP) dosimetry remains a key challenge in FLASH radiotherapy. Conventional ionization chambers (ICs) experience severe electric field perturbations under UHDP conditions due to high charge densities, leading to severe recombination. A novel IC design, the ALLS chamber, has been proposed to overcome these limitations by using a low-pressure noble gas, eliminating ion recombination, and enabling an analytical description of charge collection up to 40 Gy/pulse with argon at 1 hPa pressure as the active medium. However, designing such an IC requires meeting both dosimetric and mechanical constraints for low-pressure operation. Since the actual requirements for FLASH dosimetry involve DPP up to 10 Gy, less extreme de-pressures in the range of 50-1000 hPa could be applied, even though such a scenario cannot be described analytically. Numerical simulations and experimental measurements are essential to explore new gas and pressure configurations. - Source: PubMed
Montefiori MarcoBaldini LucaBisogni Maria GiuseppinaCavalieri AndreaCelentano MariagraziaFelici GiuseppeGómez FaustinoLucchesi LeonardoMorrocchi MatteoOrsini LeonardoPaiar FabiolaPaz-Martín JoséSgrò CarmeloMartino Fabio Di - This work investigates how the viscoelasticity of the protein layer at the oil-water interface of emulsion droplets governs the emulsion lubrication behavior. Commercially-available (PPIC) and lab-produced (PPIL) pea protein isolate, and soy protein isolate (SPI), were used to stabilize the emulsions. Whey protein isolate (WPI) served as a reference system. We found that WPI formed stiff, solid-like interfacial layers, and PPIL formed an interface that exhibits high deformability. Both interfaces were strong enough to resist mechanical stresses. In contrast, PPIC and SPI were heavily aggregated in bulk solution, forming much weaker oil-water interfaces, which were disrupted at higher stresses. The emulsion droplets stabilized by WPI or PPIL remained stable under mechanical stress, and the oil droplets were hypothesized to act as particles that limited contact between the interacting surfaces, thereby providing lubrication via a rolling/sliding mechanism. In contrast, the PPIC- and SPI-stabilized emulsions exhibited more effective friction reduction, which was hypothesized to result from oil droplet coalescence and the subsequent formation of a lubricating film. These lubrication behaviors showed a high correlation with the mechanical properties of oil-water interfaces stabilized by the proteins, i.e. elastic dilatational moduli ( and ) and viscous dissipation of the odd (U) and even (U) harmonics. These results show that protein oil-water interfacial properties, especially the mobility and resistance against density change of adsorbed proteins, are strongly correlated with lubrication properties, indicating that by structuring the oil-water interface with certain proteins, lubrication properties can be achieved, offering a strategy to tailor mouthfeel. - Source: PubMed
Publication date: 2025/12/06
Ji LeiSagis Leonard M CScholten ElkeYang Jack - Polystyrene microplastics (PS-MPs) are extensively utilized in plastic goods worldwide. The ingestion of PS-MPs has resulted in a high rate of DNA fragmentation index (DFI), which can potentially result in infertility and recurrent spontaneous abortion. This study established and characterized a mouse model of polystyrene microplastic (PS-MP)-induced sperm DNA damage (DnaD), and concurrently analyzed the associated transcriptomic and proteomic profiles. Over a period of 60 days, male mice assigned to the PS group were given PS-MPs at a dose of 1 mg/kg/d while the control group was administered an equivalent volume of normal saline. Sperm DNA Fragmentation Index (DFI) was then assessed using the Sperm Chromatin Structure Assay (SCSA).The testis was examined using RNA-seq and data-independent acquisition (DIA) to detect the patterns of mRNA and protein expression. The PS group exhibited an significant increase in the sperm DFI. Compared with the control group, 874 differentially expressed genes (DEGs) and 164 differentially expressed proteins (DEPs) were identified in the PS group. These included Agt, Gstt1, Fetub, Akr1c12, Eln, Gaa, Ppic and Ltbp2. The PI3K/Akt and metabolic pathways exhibited significant enrichment of these genes. After a 60-day period of intragastric injection, our findings indicated that the administration of PS-MPs at a 1 mg/kg/d dosage can lead to DnaD in the sperm of male mice. The metabolic and PI3K/Akt signaling pathways could be associated with the reproductive toxicity of PS-MPs. SUMMARY SENTENCE: The intake of PS-MPs mainly reduces DFI in mice via the metabolic and PI3K/Akt signaling pathways. - Source: PubMed
Publication date: 2025/11/20
Zhang ChenmingHan XiaofeiWang YifeiMa RuiminMa SichengLiu WenbangChang ZheSun Zixue