Ask about this productRelated genes to: PPIC antibody
- Gene:
- PPIC NIH gene
- Name:
- peptidylprolyl isomerase C
- Previous symbol:
- -
- Synonyms:
- CYPC
- Chromosome:
- 5q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-18
- Date modifiied:
- 2016-01-14
Related products to: PPIC antibody
Related articles to: PPIC antibody
- 2-Bromo-4,6-dinitroaniline (BDNA), a synthetic intermediate of brominated azo dyes, poses potential nephrotoxicity risks; however, its early molecular injury mechanisms remain elusive. This study integrated network toxicology prediction, machine learning algorithms (least absolute shrinkage and selection operator [LASSO], support vector machine recursive feature elimination [SVM-RFE], and random forest), and transcriptomic data mining with a 90-day subchronic male Sprague-Dawley (SD) rat exposure model to identify early biomarkers of BDNA-induced nephrotoxicity. Cross-validation of three algorithms identified CD45 (protein tyrosine phosphatase receptor type C, PTPRC) and cyclophilin C (peptidylprolyl isomerase C, PPIC) as high-confidence core targets (training area under the curve [AUC] = 0.951; validation AUCs = 0.958 and 0.929). Single-gene gene set enrichment analysis (GSEA) revealed PTPRC enrichment in immune-inflammatory pathways and PPIC in protein homeostasis-related pathways. Single-cell analysis confirmed their cell type-specific expression patterns. Subchronic BDNA exposure induced dose-dependent renal tubular epithelial injury with significant upregulation of both targets, without interstitial fibrosis or glomerulosclerosis in male SD rats. PTPRC and PPIC may serve as potential early response biomarkers for BDNA-induced renal tubular injury, involving immune-inflammatory activation and proteostasis imbalance. This study establishes an integrative toxicological framework from computational prediction to experimental validation, while acknowledging that causal roles require further functional verification. - Source: PubMed
Publication date: 2026/06/27
Zhao YongfeiZhou LiyingLiu PengheLi DonghuiFan LijunYe YixinQin Guangqiu - Glioblastoma (GBM), especially in large or unresectable tumors, remains difficult to treat because of the lack of effective debulking, the persistence of therapy-resistant glioma stem cells (GSCs), and a profoundly immunosuppressive tumor microenvironment. Here, a locoregional hydrogel platform is developed to integrate photothermal debulking, post-ablation GSC suppression, and dendritic-cell-mediated immune activation for GBM therapy. The brain-compliant injectable hydrogel (MIN-PPIC@iGel) co-encapsulates indocyanine green/napabucasin-loaded micelles and poly(I:C)-loaded polymersomes, enabling staged local release for up to 20 days. After a single intratumoral administration followed by near-infrared irradiation, MIN-PPIC@iGel achieves surgery-mimetic photothermal cytoreduction, suppresses stem-like tumor phenotypes, and induces immunogenic cell death to generate tumor antigens and danger signals. Sustained release of poly(I:C) further activates dendritic cells and converts post-ablation tumor debris into in situ vaccines. In a large orthotopic GBM model, this single-shot locoregional therapy combined with anti-CTLA-4 renders 50% of mice tumor-free and establishes durable antitumor immunity. This work provides a material-programmed locoregional strategy for integrating local cytoreduction, stemness control, and immune activation against GBM. - Source: PubMed
Publication date: 2026/06/08
Zhang XiaoshuoCai GuangZhao SongsongQu YanyiLv RunkaiSha YongjieZhu LuyingZhong ZhiyuanMeng Fenghua - Thermo-optically tunable Mach-Zehnder interferometer (MZI) switches have been popular for building robust designs of programmable photonic integrated circuits (PPICs) for various applications. In general, microheaters integrated on both arms of the MZIs are preferred to minimize power consumption by accounting for phase errors between MZI arms arising from fabrication-induced process variabilities. However, only one of the two microheaters integrated in MZI arms is chosen to drive, for achieving desired phase imbalance with lower power consumption. Again, integrating microheaters on both arms doubles the electronic control channels and as many bond pads, posing challenges for scalability and packaging. To address this, we propose a diode-assisted microheater (DAM) architecture that enables selective driving of one of the two microheaters in an MZI without increasing the pad count or control complexity. The DAM is implemented on a standard silicon photonics technology platform and is fully compatible with foundry processes. Comprehensive electrothermal simulations and subsequent experimental results confirm the CMOS foundry fabrication feasibility of such diode-assisted microheater designs. The integrated diode design exhibits low series resistance and high breakdown voltage, ensuring efficient forward operation and negligible reverse leakage. Both the diode and microheater resistances were modelled as functions of the forward current, showing excellent agreement with experimental data. DC and AC characterizations reveal that the DAM achieves efficient thermal tuning with a total power dissipation of ∼50 mW at ±3 V and a rise/fall time of ∼20 s. The DAM's performance was validated in a 1 × 4 power splitter comprising cascaded 1 × 2 MZIs, fabricated through a commercial silicon photonics foundry. Using DAM-based tuning, we achieved precise phase correction, yielding uniform power splitting with deviations of only ±0.015 dB at 1550 nm and ±0.025 dB across a 40 nm operating wavelength bandwidth. Furthermore, by employing bipolar driving and selectively activating one of the MZI arms, we experimentally demonstrated a reduction in power consumption exceeding 50 when compared with the experimental results for the same PPIC by assuming only one microheater was integrated in MZIs. These results demonstrate that the proposed DAM architecture offers a scalable, power-efficient, and foundry-compatible solution for next-generation PPICs. - Source: PubMed
Piyush KumarPandit Pawan KumarVelamuri AshitoshGoswami ArnabViraraghavan JanakiramanDas Bijoy Krishna - Ultra-high dose-per-pulse (UHDP) dosimetry remains a key challenge in FLASH radiotherapy. Conventional ionization chambers (ICs) experience severe electric field perturbations under UHDP conditions due to high charge densities, leading to severe recombination. A novel IC design, the ALLS chamber, has been proposed to overcome these limitations by using a low-pressure noble gas, eliminating ion recombination, and enabling an analytical description of charge collection up to 40 Gy/pulse with argon at 1 hPa pressure as the active medium. However, designing such an IC requires meeting both dosimetric and mechanical constraints for low-pressure operation. Since the actual requirements for FLASH dosimetry involve DPP up to 10 Gy, less extreme de-pressures in the range of 50-1000 hPa could be applied, even though such a scenario cannot be described analytically. Numerical simulations and experimental measurements are essential to explore new gas and pressure configurations. - Source: PubMed
Montefiori MarcoBaldini LucaBisogni Maria GiuseppinaCavalieri AndreaCelentano MariagraziaFelici GiuseppeGómez FaustinoLucchesi LeonardoMorrocchi MatteoOrsini LeonardoPaiar FabiolaPaz-Martín JoséSgrò CarmeloMartino Fabio Di - This work investigates how the viscoelasticity of the protein layer at the oil-water interface of emulsion droplets governs the emulsion lubrication behavior. Commercially-available (PPIC) and lab-produced (PPIL) pea protein isolate, and soy protein isolate (SPI), were used to stabilize the emulsions. Whey protein isolate (WPI) served as a reference system. We found that WPI formed stiff, solid-like interfacial layers, and PPIL formed an interface that exhibits high deformability. Both interfaces were strong enough to resist mechanical stresses. In contrast, PPIC and SPI were heavily aggregated in bulk solution, forming much weaker oil-water interfaces, which were disrupted at higher stresses. The emulsion droplets stabilized by WPI or PPIL remained stable under mechanical stress, and the oil droplets were hypothesized to act as particles that limited contact between the interacting surfaces, thereby providing lubrication via a rolling/sliding mechanism. In contrast, the PPIC- and SPI-stabilized emulsions exhibited more effective friction reduction, which was hypothesized to result from oil droplet coalescence and the subsequent formation of a lubricating film. These lubrication behaviors showed a high correlation with the mechanical properties of oil-water interfaces stabilized by the proteins, i.e. elastic dilatational moduli ( and ) and viscous dissipation of the odd (U) and even (U) harmonics. These results show that protein oil-water interfacial properties, especially the mobility and resistance against density change of adsorbed proteins, are strongly correlated with lubrication properties, indicating that by structuring the oil-water interface with certain proteins, lubrication properties can be achieved, offering a strategy to tailor mouthfeel. - Source: PubMed
Publication date: 2025/12/06
Ji LeiSagis Leonard M CScholten ElkeYang Jack