Ask about this productRelated genes to: IFNa2 protein (Mouse)
- Gene:
- IFNA2 NIH gene
- Name:
- interferon alpha 2
- Previous symbol:
- -
- Synonyms:
- IFNA, IFN-alphaA
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
Related products to: IFNa2 protein (Mouse)
Related articles to: IFNa2 protein (Mouse)
- Colorectal cancer (CRC) is a highly prevalent and lethal digestive system malignancy worldwide, which mostly develops through a multi-step progression from normal mucosa to adenoma and finally invasive carcinoma. Lack of specific biomarkers for precancerous lesions limits early screening and intervention efficacy. This study aimed to investigate the differential expression of Dickkopf-related protein 4 (DKK4) in CRC and its correlation with clinicopathological features, and to construct a DKK4-based risk prediction model for CRC. - Source: PubMed
Publication date: 2026/05/27
Wang XiaoxiongShan MinghaiQiao XiaDing LuYang JialiHe FangMian YushenZhang XuYang Shaoqi - Inflammatory response-related signaling pathways are associated with Atherosclerosis (AS), yet the particular inflammation-related genes underpinning this process are still not fully characterized. - Source: PubMed
Publication date: 2026/05/20
Xu XuJiang MeilingHuang ZeyunZhu Guofu - Allergic asthma and allergic rhinitis (AR) are among the most frequent chronic conditions in the pediatric age. They frequently coexist in children and are sustained by type 2- driven airway inflammation and impaired epithelial-immune interactions. Immunonutritional and postbiotic strategies have been proposed as adjunctive therapeutic approaches for these diseases. - Source: PubMed
Publication date: 2026/05/27
Caldaria ErikaIorio RaffaeleMarziali DarioOglio FrancaCadavere AlessiaMasino AntonioAgizza AlessandraCoppola SerenaCarucci Laura - Cow's milk allergy (CMA) is one of the most common food allergies in childhood frequently associated with body growth impairment and micronutrient deficiencies. Immunonutrition approach with selected bioactive compounds may have beneficial effects on nutritional status and immune tolerance mechanisms. We evaluated the effects of an immunonutrition approach, based on the use of a novel multicomponent food supplement containing prebiotics, postbiotics, vitamin D3, docosahexaenoic acid (DHA), extracts, and Quercetin in children with CMA. - Source: PubMed
Publication date: 2026/03/16
Carucci LauraCaldaria ErikaOglio FrancaIorio Raffaele FedericoMauriello VittoriaMasino AntonioCoppola Serena - Prediabetes is accompanied by early β-cell stress and oxidative imbalance before overt hyperglycemia. Circulating extracellular vesicle (EV) microRNAs (miRNAs) may capture early metabolic disturbances, but their mechanistic relevance remains unclear. Plasma EV miRNA profiles were analyzed across normoglycemia, prediabetes, and newly diagnosed type 2 diabetes, with validation in an independent cohort (n = 150). Functional studies were performed in pancreatic β-cells exposed to glucolipotoxic stress to examine miRNA regulation, IFN-α signaling, mitochondrial redox status, and insulin secretion. Six EV miRNAs, including miR-186-5p, were consistently reduced in prediabetes and correlated with glycemic and insulin resistance indices. In β-cells, glucolipotoxic stress selectively suppressed miR-186-5p, leading to derepression of IFNA2, activation of IFN-α-JAK/STAT signaling, increased mitochondrial ROS, impaired ATP/ADP dynamics, and reduced glucose-stimulated insulin secretion. Restoration of miR-186-5p or pharmacologic JAK inhibition mitigated these defects, and luciferase assays confirmed IFNA2 as a direct target of miR-186-5p. EV-associated miR-186-5p represents an early marker of metabolic stress in prediabetes and provides mechanistic insight into IFN-α-driven oxidative and secretory dysfunction in β-cells. - Source: PubMed
Publication date: 2026/01/23
Park Jae-HyungNguyen Thi NhiShim Hye MinBae Yun-UiYu Gyeong ImKang JunhoHa Eun YeongCho Hochan