Ask about this productRelated genes to: IFNa2 protein (Mouse)
- Gene:
- IFNA2 NIH gene
- Name:
- interferon alpha 2
- Previous symbol:
- -
- Synonyms:
- IFNA, IFN-alphaA
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
Related products to: IFNa2 protein (Mouse)
Related articles to: IFNa2 protein (Mouse)
- Approximately 85-90% of colorectal cancers (CRC) are microsatellite stable and resist immune checkpoint inhibitors (ICI). The recent success of intismeran, a lipid nanoparticle (LNP)-delivered mRNA encoding patient-specific tumor antigens, enhances pembrolizumab responses, showing that LNP-delivered nucleic acids can render ICI-resistant tumors responsive by supplying what the tumor microenvironment lacks. Because an IFN-responsive phenotype predicts CRC response to checkpoint blockade and tumor cell PD-L1 represses IFN-I, we asked whether delivering the missing cytokine, rather than antigen, achieves the same conversion. Here we show that PD-1 blockade failed even when initiated before tumor seeding, yet deleting tumor cell PD-L1 abolished colon cancer lung metastasis, implicating a tumor-intrinsic PD-L1 function that antibody blockade does not neutralize. An LNP-encapsulated IFNα2-encoding nanoplasmid (LNP-IFNα2) transfected tumor cells within lung metastases, converting them into a self-sustaining and tumor-restricted IFNα2 source. LNP-IFNα2 suppressed colon cancer lung metastasis in syngeneic and humanized mouse models and sensitized these ICI-resistant tumors to PD-1 blockade. Efficacy improved further with neutralization of co-induced IL6. scRNA-Seq revealed multi-compartment reprogramming: SPP1+ macrophages acquired apoptotic signatures as IFN-responsive monocytes replaced them, progenitor-exhausted T cells exited quiescence and expanded, and tumor cells exited a high-cycling state, gained antigen presentation, and shifted away from cuproptosis resistance. The treated microenvironment transcriptionally recapitulated pembrolizumab-responder signatures, positioning LNP-IFNα2 as an off-the-shelf nanomedicine for ICI-resistant CRC. - Source: PubMed
Publication date: 2026/08/28
Tiamiyu ZainabCzabala PatrickWorthy JenniferZarate Luis VelasquezZheng MeiPoschel Dakota BFick KendraYang DafengMonnig Henry RRashmi RichaBombin SergeiRedd Priscilla SLiu Kebin - Colorectal cancer (CRC) is a highly prevalent and lethal digestive system malignancy worldwide, which mostly develops through a multi-step progression from normal mucosa to adenoma and finally invasive carcinoma. Lack of specific biomarkers for precancerous lesions limits early screening and intervention efficacy. This study aimed to investigate the differential expression of Dickkopf-related protein 4 (DKK4) in CRC and its correlation with clinicopathological features, and to construct a DKK4-based risk prediction model for CRC. - Source: PubMed
Publication date: 2026/05/27
Wang XiaoxiongShan MinghaiQiao XiaDing LuYang JialiHe FangMian YushenZhang XuYang Shaoqi - Inflammatory response-related signaling pathways are associated with Atherosclerosis (AS), yet the particular inflammation-related genes underpinning this process are still not fully characterized. - Source: PubMed
Publication date: 2026/05/20
Xu XuJiang MeilingHuang ZeyunZhu Guofu - Allergic asthma and allergic rhinitis (AR) are among the most frequent chronic conditions in the pediatric age. They frequently coexist in children and are sustained by type 2- driven airway inflammation and impaired epithelial-immune interactions. Immunonutritional and postbiotic strategies have been proposed as adjunctive therapeutic approaches for these diseases. - Source: PubMed
Publication date: 2026/05/27
Caldaria ErikaIorio RaffaeleMarziali DarioOglio FrancaCadavere AlessiaMasino AntonioAgizza AlessandraCoppola SerenaCarucci Laura - Cow's milk allergy (CMA) is one of the most common food allergies in childhood frequently associated with body growth impairment and micronutrient deficiencies. Immunonutrition approach with selected bioactive compounds may have beneficial effects on nutritional status and immune tolerance mechanisms. We evaluated the effects of an immunonutrition approach, based on the use of a novel multicomponent food supplement containing prebiotics, postbiotics, vitamin D3, docosahexaenoic acid (DHA), extracts, and Quercetin in children with CMA. - Source: PubMed
Publication date: 2026/03/16
Carucci LauraCaldaria ErikaOglio FrancaIorio Raffaele FedericoMauriello VittoriaMasino AntonioCoppola Serena