Ask about this productRelated genes to: IL17C protein
- Gene:
- IL17C NIH gene
- Name:
- interleukin 17C
- Previous symbol:
- -
- Synonyms:
- IL-17C, CX2, IL-21, MGC126884, MGC138401
- Chromosome:
- 16q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2016-10-11
Related products to: IL17C protein
Related articles to: IL17C protein
- Crohn's disease (CD) is a chronic inflammatory bowel disease with increasing global prevalence, significantly impacting patients' quality of life and healthcare costs. The introduction of monoclonal antibodies has revolutionized CD management, offering targeted therapy against specific inflammatory pathways. This review systematically analyzes the current state of monoclonal antibody therapy, including anti-TNF-α agents (infliximab, adalimumab, certolizumab pegol), anti-integrin antibodies (vedolizumab), and anti-cytokine therapies (ustekinumab, risankizumab). Despite remarkable therapeutic advances, significant limitations persist, including primary non-response (20%-40%), secondary loss of response (13%-20% annually), immunogenicity, safety concerns, and substantial economic burden. We propose evidence-based strategies to address these challenges, including therapeutic drug monitoring, combination therapy, and personalized medicine approaches. Furthermore, we identify promising novel therapeutic targets such as IL-36, IL-17C, SMAD7, TL1A, complement components, and microbiome-related factors. Targeting two or more specific targets simultaneously appears to be a promising direction of research for the development of bi- and polyspecific monoclonal antibodies capable of interfering with multiple pathological pathways in CD. The integration of advanced antibody engineering, personalized medicine, and innovative delivery systems represents the future direction for overcoming current limitations. Achieving sustained remission for all patients through safe, effective, and accessible therapeutic interventions remains the ultimate goal in CD management. - Source: PubMed
Publication date: 2026/02/10
Blagov Alexander VSazonova Marina DRyzhkova Anastasia IKaragodin Vasily PPopov Mikhail ABudnikov Egor YuRavani Alessio LOrekhov Alexander NSazonova Margarita AArkhipenko Yuri V - Sex is an important determinant for various immune system-related pathologies and sex steroids might possess immunomodulatory properties. - Source: PubMed
Publication date: 2026/04/01
Sertons YaëlCollet SarahVervalcke JeroenDefreyne JustineMueller Sven CHofmans MattiasBonroy CarolienD'Onofrio ValentinoSnaterse GidoT'Sjoen GuyLapauw Bruno - Gut microbiota is a key player in colorectal cancer (CRC) proliferation. Parvimonas micra (P. micra), an obligate anaerobic bacterium that colonizes the oral cavity and gastrointestinal tract, has been implicated in CRC development. However, its virulence factors and pathogenic mechanisms remain poorly understood. - Source: PubMed
Publication date: 2026/03/17
Chang YuxiaoYang ChaoHou FengyiZhu YubingHuang ZiranWang LikunLiu YuejiaoZhang HuanQin XiaomingHao ZichuangLi DongTan YafangBai YinlanDing LeiGao HongZhi FachaoZhang FanglinBi YujingYang Ruifu - Mass vaccination with attenuated infectious laryngotracheitis virus (ILTV) via drinking water is commonly used in commercial chicken farms, although the effectiveness of oral (OR) vaccination is lower than eye drop (ED). The gene expression of a select set of immune markers associated with inflammatory responses (TLR4, TLR7, TLR2-2, IL6, CCL4, CCR5, IFNγ, IL2, IL17C), immune synapse (CD80), T helper cell polarisation (IL4) and effector cell receptors (CD4, CD8α and CD14), following OR and ED primary vaccination and revaccination using the same or alternate route [ED/ED (primary/revaccination), OR/OR, ED/OR and OR/ED] with ILTV SA2 strain in chickens were evaluated. Both ED and OR primary vaccinations were associated with increased gene expression of inflammation-associated markers in the conjunctiva and trachea, with a statistical interaction between application route and profile of immune responses. Revaccination via the alternative route elicited upregulation of more immune markers in the conjunctiva and trachea compared to other methods, while most immune markers were downregulated in the ED/ED group, and close to baseline in the OR/OR group. In conclusion, the immune responses in the conjunctiva and trachea following the ED and OR primary vaccination with ILTV vaccine were tissue-specific, showing increased gene expression of markers related to the inflammatory response. Revaccination using the alternative route elicited upregulation of markers associated with inflammatory responses CCR5 and TLR7 in the conjunctiva and/or trachea. Challenge studies are necessary to confirm the role of these immune responses in protecting vaccinated birds from ILTV. - Source: PubMed
Publication date: 2026/03/18
Tran Thanh TienAndronicos Nicholas MKetheesan NatkunamWalkden-Brown Stephen WGerber Priscilla F - People with Cystic Fibrosis (pwCF) are prone to bacterial lung infections with P. aeruginosa, which have been linked to chronic inflammation in the lung. Although the highly effective CFTR modulator therapy (Elexacaftor-Tezacaftor-Ivacaftor, ETI) has dramatically improved respiratory outcomes in pwCF, airway inflammation and bacterial colonization persist in the upper and lower respiratory tracts. - Source: PubMed
Publication date: 2026/03/17
Allegretta CaterinaGuidone DanielaBoscia SilviaPisano LauraRicci SilviaAzzari ChiaraFevola CristinaDe Santis MartinaCiciriello FabianaMontemitro EnzaDolce DanielaCabrini GiulioGalietta Luis J VTerlizzi VitoLaselva Onofrio