Ask about this productRelated genes to: Gata4 antibody
- Gene:
- GATA4 NIH gene
- Name:
- GATA binding protein 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-11-30
- Date modifiied:
- 2016-10-05
Related products to: Gata4 antibody
Related articles to: Gata4 antibody
- Maternal sucralose exposure during pregnancy has been demonstrated to interfere embryonic development, yet limited studies have investigated its potential hazards on fetal cardiogenesis. In the present study, we employed a mice model to investigate the impact of sucralose exposure in early pregnancy on the risk of heart defects in offspring. Pregnant C57BL/6J mice received either control or sucralose water. The incidence of heart defects in the sucralose group was 13.86%, significantly higher than that in the control group. Transcriptional downregulation of cardiogenic genes involving , , , and were confirmed, potentially due to increased CREB phosphorylation. N-acetylcysteine (NAC) reduced CREB phosphorylation, partially reversed sucralose-induced suppression of cardiogenic genes, and reduced the incidence of heart defects from 16.67% to 4.81%. Our study demonstrates that sucralose exposure during early pregnancy increases the risk of heart defects via transcriptional suppression of cardiogenic genes, while NAC potentially functions as a protective factor. - Source: PubMed
Publication date: 2026/04/04
Zhang ZehuaYu ZiwenShi HaiqunDing TongShi YanZhao JianyuanCai KeWang Feng - The expanding use of ternary lithium-ion batteries has raised growing concerns about their potential ecological and health risks in recent years. This study aimed to investigate the effects and underlying mechanisms of the ternary lithium-ion battery cathode material lithium nickel-cobalt-manganese oxide (NCM523) on planarian locomotor activity, growth, and regeneration, providing insight into the environmental and ecological hazards. Freshwater planarians (Dugesia japonica) were exposed to NCM523-shrimp paste mixtures via feeding. The median lethal concentration (LC), locomotor activity, growth, regeneration capacity, oxidative stress markers, and expression levels of related genes were evaluated. Exposure to NCM523 induced significant toxicity in planarians, with a 72-h LC of 401.5 μg mg⁻¹ (95% CI: 387.7 to 418.1). Elevated malondialdehyde (MDA) levels and increased superoxide dismutase (SOD) activity, together with reduced glutathione peroxidase (GPx) and catalase (CAT) activities, indicated that NCM523 exposure triggered oxidative stress in a concentration-dependent manner. Concurrently, planarians exhibited reduced locomotor activity and marked delays in both growth and regeneration as NCM523 concentrations increased. These physiological impairments were accompanied by upregulation of regeneration-associated genes, including Dj-GATA4/5/6, Dj-PCNA, and Dj-nlg. In conclusion, these findings demonstrate that NCM523 adversely affects planarian locomotor activity, growth, and regeneration, providing crucial in vivo evidence for assessing the potential ecotoxicological risks of ternary lithium-ion battery cathode materials. - Source: PubMed
Publication date: 2026/04/11
Chen ZhichengDeng YufanLi YingWu LuyinZheng ShuhanWang ZiyiChen ShiRen YixianZhang YuxiaTang ShihaoWang ZhiOu Zejin - The pathogenesis of heart failure involves a highly intricate process regulated by diverse epigenetic factors, transcription factors, noncoding RNAs, and cyclins. Notably, the reexpression of embryonic cardiac transcription factors, including , , and , is considered to exert critical influence in the initiation and advancement of heart failure. Nevertheless, the precise mechanisms through which epigenetic modifications drive this reprogramming of gene expression remain poorly defined. This investigation aims to clarify the role of histone acetylation in regulating the reexpression of embryonic cardiac transcription factors during heart failure. Our research indicates that during heart failure of mice, there are distinct histone acetylation modifications associated with the reexpression of these factors. Notably, and show significant increases, whereas shows a decrease compared to normal groups during heart failure progression. These findings imply that embryonic and may promote the development of heart failure, whereas does not appear to participate in disease progression. Furthermore, treatment with curcumin, a known inhibitor of histone acetylation, reduces acetylation levels at H3K4, H3K9, and H3K27 within the promoter regions of and in a murine model of heart failure, leading to downregulation of these genes and subsequent enhancement of cardiac performance. In summary, our study demonstrates that p300 exerts site-specific regulatory effects on various transcription factors via histone modifications, and low acetylation status at specific sites can inhibit reactivation of and during the myocardial dysfunction period thereby improving cardiac performance of mice. - Source: PubMed
Publication date: 2026/03/27
Gan XinruPan BoLiu LingjuanLi MiSun Huichao - Human germ cell tumors (GCTs) occur in infants, children, and adults, and present as germinomatous and/or non-germinomatous (embryonal carcinoma (EC), teratoma, yolk sac tumor (YST), and choriocarcinoma) histologies at gonadal or extragonadal locations. Accurate subtyping is crucial for prognosis and treatment, but current clinical biomarkers lack sensitivity and specificity (serum proteins), or require a tissue biopsy (for histological and immunohistochemical characterization). Hence, less-invasive and improved subtype-specific biomarkers have significant potential for clinical utility. - Source: PubMed
Publication date: 2026/04/17
Janssen Ferdinand WGillis Ad J MGouswaart Puck BKester Lennart ATakami HirokazuIchimura KoichiEleveld Thomas FLooijenga Leendert H J - Ménière's disease (MD), a chronic inflammatory disorder with age-related increased incidence, exhibits poorly understood pathogenesis and limited therapeutic options. Here, we demonstrate that cellular senescence, marked by mitochondrial damage, reactive oxygen species accumulation, and senescence-associated secretory phenotype (SASP), is prevalent in the vestibular tissue of MD patients and an endolymphatic hydrops mouse model. The transcription factor GATA4 is upregulated in MD and mice, and its genetic deletion in hair cells alleviates LPS-induced audio-vestibular dysfunction and cellular senescence in mice and HEI-OC1 cells. Mechanistically, HDAC6 interacts with GATA4 and restrains its nuclear transport, while RNA-seq and ChIP-seq identify HtrA1, a serine protease, as a direct transcriptional target of GATA4. Inhibition of HDAC6 or AAV-mediated HtrA1 overexpression exacerbates MD-like symptoms, whereas inhibition of HtrA1 by Galegenimab ameliorates these phenotypes in mice. In aged mice, GATA4 deletion reduces age-related audio-vestibular deficits and senescence markers. Collectively, our findings establish GATA4 as a critical regulator of cellular senescence and inflammaging in inner ear pathologies, providing promising therapeutic targets for MD and age-related audio-vestibular disorders. - Source: PubMed
Publication date: 2026/04/14
Zhang NaLi NaWang YanZhang JingLiu JiahuiChen LeiSong YongdongMu YurongHan YuechenLyu YafengLi XiaofeiWang HanyueWang JingLu YaoFan ZhaominZhang DaogongWang Haibo