Ask about this productRelated genes to: IL1a antibody
- Gene:
- IL1A NIH gene
- Name:
- interleukin 1 alpha
- Previous symbol:
- IL1
- Synonyms:
- IL1F1, IL-1A, IL1-ALPHA
- Chromosome:
- 2q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: IL1a antibody
Related articles to: IL1a antibody
- High tumor expression of the cytokine interleukin-1 alpha (IL-1α) is associated with an aggressive tumor phenotype and poor clinical outcomes in head and neck squamous cell carcinoma (HNSCC). However, the mechanism behind IL-1α-induced tumor aggressiveness is unclear. The goal of this work is to investigate the biological consequences of increased IL-1α in HNSCC cells. Three IL1A constructs (Full-length, N-terminal, and C-terminal [CT]) were transduced into Cal27 HNSCC cells and validated for IL-1α expression. Differences in cell survival, metabolic profiling, epithelial-to-mesenchymal transition (EMT), oxidative stress parameters and response to therapy were compared among the parental and IL-1α overexpressing cell lines. Overexpression of CT IL-1α (but not the other constructs) led to increased cell proliferation, membrane fluidity, hydroperoxide production, intracellular iron and lipid peroxidation, EMT changes, and a shift toward glutamate utilization compared to control cell lines. Finally, CT IL-1α cells (but not the other constructs) were highly sensitive to the ferroptosis inducer RSL3. Together this work suggests that increased tumor IL-1α expression triggers a shift toward an oxidative and ferroptotic environment, leading to an aggressive tumor phenotype and drug resistance; but also reveals a unique vulnerability to agents that induce ferroptosis. - Source: PubMed
Publication date: 2026/04/16
Khan Ishrat NourinAwasthi KrishnaWang ZiyuIrfan Nafis MdSaepoo JayWhittier Joan NKoyuncu NurgulMogal Md RomanHasibuzzaman M MYang ShujiePetronek MichaelSimons Andrean L - U6 biogenesis 1 (USB1) gene mutations cause poikiloderma with neutropenia (PN), which is clinically characterized by skin hyperpigmentation, nail dysplasia, neutropenia, and an elevated risk of cancer. USB1 functions as an RNA exonuclease involved in RNA maturation and stability regulation, although its precise mechanism of action in the hematopoietic system remains unclear. - Source: PubMed
Publication date: 2026/04/20
Li HangShi GuiyingTang JiamingHuang YiyingWang JieLei XuepeiBai Lin - Tissue resident host responses to microbial infections in the respiratory tract are highly dynamic in space and time and rely on the interaction of a multitude of cell types. To model these multicellular responses reliably in cell culture, we compare here the global transcriptional antimicrobial response to infection with influenza A virus (IAV) in precision cut lung slices (PCLS), volume-defined organ discs largely maintaining the cellular composition and 3D architecture of the donor lung. To permit a fair comparison of host responses in an isogenic background, we first challenged mice and murine PCLS (mPCLS) and assessed host transcriptomic changes by unbiased RNA-sequencing. While core antiviral responses overlapped substantially, mPCLS lacked certain features-such as type II interferon expression-likely due to the absence of infiltrating immune cell responses. Importantly, when expanding our findings to immune-experienced human precision cut lung slices (hPCLS), we find a much broader antiviral response after IAV challenge, including types I, II, and III interferons, suggesting the presence of responsive tissue resident lymphocytes. To prove the specificity of this response, we infected hPCLS with tissues responded with a distinct proinflammatory gene profile including IL1A, IL1B, and IL17 expression. Blocking of IL-1β signaling partially inhibited the proinflammatory response, suggesting cellular cross talk and a complex and specific antimicrobial reaction in this model. In conclusion, a diversified tissue resident immune cell compartment distinguishes the human model, making it an ideal system for microbiological and immunological research. - Source: PubMed
Publication date: 2026/04/16
Choltus HélènaBianchi NiccoloPrados JulienHeikkila NelliKarenovics WolframSerre Beinier VeroniqueNissille YannickLeitner NinaBédat BenoitBezrukov FedorMazel-Sanchez BerylPrendki VirginieLobrinus AlexanderEberhardt ChristianeBecattini SimoneSchmolke Mirco - To determine whether rapamycin affects HLA-B27-mediated gut inflammation in experimental spondyloarthritis (SpA). - Source: PubMed
Publication date: 2026/03/20
Van Doorn JinnyBrooks Stephen RLiCausi FrancescaZhou KellyBetrapally Naga SGubitz-Hess EvaCougnoux AntonyDell'Orso StefaniaIslam ShamimaColbert Robert ANavid Fatemeh - We sought to determine changes in the expression of immune response-related genes occurring in surgical necrotizing enterocolitis (NEC) tissues from infants with necrosis severity and survival status. - Source: PubMed
Publication date: 2026/03/24
Garg Parvesh MohanRiddick RobinZhang PengboShenberger JeffreyVarshney NehaSawaya DavidGarg Padma