Ask about this productRelated genes to: VEGFR1 antibody
- Gene:
- FLT1 NIH gene
- Name:
- fms related tyrosine kinase 1
- Previous symbol:
- FLT
- Synonyms:
- VEGFR1
- Chromosome:
- 13q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: VEGFR1 antibody
Related articles to: VEGFR1 antibody
- Tokishakuyakusan is a traditional Japanese Kampo medicine widely prescribed for gynecological disorders, including reproductive dysfunction. - Source: PubMed
Publication date: 2026/09/22
Terawaki KiyoshiHarada-Nitta ShioriTakiyama MikinaTsuchiya NaokoNahata MiwaFujitsuka NaokiTokita Yohei - Doxorubicin (DOX) remains an effective antineoplastic agent; however, its clinical use is frequently limited by adverse effects, including hepatotoxicity. Indole-3-acetic acid (IAA), a naturally occurring tryptophan-derived metabolite, has recently attracted attention because of its cytoprotective and immunomodulatory properties. The present study investigated the potential protective effect of IAA against DOX-induced liver injury and explored its effect on oxidative stress, inflammation, apoptosis, VEGF/FLT1 axis and Nrf2/HO-1 signaling. Rats received IAA (40 mg/kg) for 14 days and a single injection of DOX (15 mg/kg) on day 7. DOX induced marked hepatic injury, evidenced by elevated serum aminotransferases and ALP, reduced albumin, and histopathological abnormalities. These changes were accompanied by increased lipid peroxidation, upregulated Bax and caspase-3, and depletion of GSH, SOD and catalase. DOX also increased NF-κB, TNF-α, IL-1β, and Keap1 while suppressing IL-10, Nrf2, HO-1, and NQO-1. Furthermore, VEGF and FLT1 expression were significantly elevated following DOX exposure. Treatment with IAA attenuated liver damage, restored antioxidant status, reduced inflammatory cytokine production and NF-κB, and mitigated apoptosis through modulation of Bax, Bcl-2, and caspase-3. In addition, IAA ameliorated VEGF/FLT1 signaling, downregulated Keap1 and restored Nrf2, HO-1 and NQO-1 expression while simultaneously increasing HO-1 and NQO-1 enzymatic activities. Molecular docking analyses predicted favorable interactions between IAA and Keap1, HO-1, NF-κB p65, caspase-3, and FLT1. In conclusion, IAA treatment was associated with attenuation of acute DOX-induced hepatic injury, as evidenced by improvements in histopathological alterations, serum liver injury markers, oxidative stress parameters, inflammatory mediators, and apoptotic markers. The hepatoprotective activity of IAA appears to involve modulation of VEGF/FLT1 and Nrf2/HO-1 signaling. These findings identify IAA as a promising adjunctive candidate for reducing hepatic adverse effects associated with DOX therapy. - Source: PubMed
Publication date: 2026/09/15
Hasan Iman HAlqahtani Qamraa HAlshehri Samiyah MAljarboa Amjad SMansy Tasneem WEl Fouhil Ahmed FMohammed RaeesaMahmoud Ayman M - Brazilian green propolis is notable for its ability to modulate immune cells. In preeclampsia (PE), endothelial dysfunction is caused by the release of damage-associated molecular patterns, oxidative stress, elevated pro-inflammatory cytokines, and adhesion molecules. This study aimed to evaluate the effects of propolis on biomarkers of endothelial dysfunction and oxidative stress using human umbilical vein endothelial cells (HUVECs). - Source: PubMed
Ribeiro-Vasques Vanessa RochaRomao-Veiga MarianaNunes Priscila RezeckPasseti Luis Fernando PereiraFranco Gabriela de OliveiraBraga da Silva Patriciade Oliveira Larissa Ragozo CardosoPeracoli Jose CarlosPeracoli Maria Terezinha SerraoSforcin Jose Mauricio - Preeclampsia (PE) is a serious complication of pregnancy, with vascular endothelial dysfunction being a core pathological feature. This study aimed to investigate whether L-(+)-ergothioneine (LET) ameliorates PE-associated endothelial dysfunction by regulating the Nrf2-PPARγ-sFlt-1 axis. - Source: PubMed
Publication date: 2026/09/18
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