CD95 Ligand antibody
- Known as:
- CD95 Ligand (anti-)
- Catalog number:
- 10r-6576
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- CD95 Ligand antibody
Related genes to: CD95 Ligand antibody
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 Ligand antibody
Related articles to: CD95 Ligand antibody
- Lipids constitute the majority of brain dry weight and play essential structural and signaling roles. During early life, their supply depends largely on breast milk, yet how milk composition aligns with brain fatty acids (FA) across species has not been systematically explored. We analyzed 837 milk samples from seven mammalian species and 194 brain samples from five species using LC-MS. We identified 81 FA in milk and 33 in brain, with 31 shared across both tissues. FA composition in milk and brain was strongly correlated, particularly in humans and macaques, with the strongest associations observed in the prefrontal cortex and during the first four weeks postpartum. Humans were uniquely enriched in very- and ultra-long-chain unsaturated FAs (≥24 carbons) in both milk and brain, suggesting a role in species-specific neurodevelopment. Infant formula clustered closer to bovids than to human milk, underscoring compositional differences of potential nutritional relevance. These findings reveal conserved and human-specific features of milk and brain FAs, highlight the importance of early milk supply for neurodevelopment, and provide evolutionary and translational insights into infant nutrition. - Source: PubMed
Publication date: 2026/04/22
Mitina AleksandraWang YunmeiMair WaltraudVanyushkina AnnaAnikanov NickolayEfimova OlgaGuo SongMazin PavelKhaitovich Philipp - Fatty acids (FAs), as the predominant organic acids, form a major component of the metabolome. We present a multi-tiered method that comprehensively captures FA diversity-including chain lengths (C2-C34), unsaturation, isomers, and endogenous forms-within a single biological specimen. This workflow quantifies the broadest range of free FAs reported to date. Integrated with two complementary tiers profiling the total FA pool from alkaline hydrolysis and esterified acyl compositions across lipid classes, our multi-tiered workflow enables the investigation of differential fatty acyl partitioning. Applying this platform to quantify >540 unique lipids (free and esterified forms) and polar carboxylic acids, we investigated FA remodeling in the brain, retina (eyeball), and skeletal muscles of young and aged mice. We found that aged glycolytic tissues preferentially partition odd-chain and diunsaturated FAs (with lower β-oxidizability) into triacylglycerols. Additionally, aging shifts the FA18:1 partitioning into diacylglycerols over anionic phospholipids, which may mitigate pro-aging lipid signatures in the skeletal muscle. - Source: PubMed
Publication date: 2026/04/21
Zhou ZhiyangCao ChenyinLu TaochaoRuan YuyuanLi BowenCao MingjunMo LuyueShui GuanghouLam Sin Man - Extensive research continues to address the challenges of developing standard cancer drugs. However, until more effective standard drugs are developed, ferulic acid (FA) may be a potential option for controlling the symptoms of cancer patients. According to our review, FA is available in natural sources and has flexible structures that possess diverse pharmacological activities. FA is effective against 16 different cancer types and has been validated in cell culture, preclinical, and clinical models. Chemotherapeutics activities of FA are regulated through varieties of mechanisms, including targeting signaling pathways, such as AKT/PI3K/mTOR/ERK/STAT NF-κB; apoptosis, such as FAS/FASL, TRADD, Bcl2, Bax, Caspases, and PARP; metastasis, such as MMPs(1,2,9), Wnt/-β catenin, angiogenesis (E&N Cadherin, vimentin, Snail, and Slug), cell proliferation (cyclin D1, E1, and CDKs(2,4,6)), inflammatory molecules (TNF-α, NF-κB,1α, IL-10, IL-8, and IL-6), regulating tumor suppressor genes (p-RB, p21, and p53), autophagy (LC3-II, p62, Beclin1, and Atg12-Atg5), glycolysis (lncRNA 495810 and PKM2), heat shock protein (Hsp60, Hsp70, and Hsp90), and some nonspecific pathways, such as oncogene suppression and antioxidant efficacies. Nanoformulation of FA increased its solubility, stability, and bioavailability, thereby enabling controlled release and making FA more effective against cancer. Additionally, FA exerted synergistic effects with other natural compounds, vitamins, radiotherapy, and chemotherapies, and reversed resistance to existing chemotherapies via diverse mechanisms, including targeting multidrug resistance proteins, apoptosis, reactive oxygen species production, hypoxia, microRNA, the β-catenin pathway, oncogene activation, and sensitizing chemotherapies and radiotherapies. Given that FA has validated the experimental model and demonstrated preliminary efficacy, these findings suggest a possible supportive role for phytochemicals pending the development of fully effective pharmaceutical therapies. - Source: PubMed
Publication date: 2026/04/20
Khatun SanzidaSohel MdBarman ZituSalma UmmeArbia LubatulSarker Md RifatJame Jasmin AkterDey Badhan RaniParvin SultanaShuvo Md Shah PoranIslam Md ShahidulMannan TaniaDas Snygdha RaniHasan Md Mahmudul - Oocyte formation in mammals is a tightly regulated process essential for female fertility, yet the underlying mechanisms remain poorly understood. In this study, we establish an ex vivo culture system that faithfully recapitulates in vivo development and enables long-term live imaging of mouse fetal ovaries. Using high resolution imaging, we capture the dynamic behaviors of germ cells during the development from oogonia to nascent oocytes. We identify pronounced blebbing activity during the mitosis-to-meiosis transition. This behavior is regulated by meiotic initiation signals, underscoring its potential developmental relevance, although its precise role remains unclear. A prevailing model suggests that oocyte formation involves organelle transfer from neighboring germ cells during cyst breakdown. However, through photoconversion-based tracking, we observe no detectable transfer of mitochondria or centrosomes, as organelles remain confined to individual cells. These findings point to alternative mechanisms for cytoplasmic enrichment in oocytes. Our study provides new insights into mammalian oocyte formation and establishes a powerful platform for analyzing germ cell dynamics in real time. - Source: PubMed
Publication date: 2026/04/21
Aizawa EishiShimamoto SoKajikawa ErikoHara JunkoAbe TakayaShibuya HirokiKitajima Tomoya S - Human cognitive and social behaviors differ from those of other mammals, but the molecular, cellular and circuit-level changes that underlie these behavioral differences are poorly understood. The recent availability of thousands of mammalian, non-human primate, ancient human and modern human genomes now makes it possible to use quantitative approaches to identify genomic regions with signatures of selection in humans, which, when combined with comparative experimental approaches, can provide precise insights into the phenotypes that were the targets of adaptation across different evolutionary timescales. This Review presents a progress report on a 'genome-up' approach to understanding human brain evolution and lays out a framework for further advancement. Additional progress will require cohort expansion to improve the identification of genetic loci under selection, the application of comparative experimental approaches to additional milieus and the functional dissection of specific human-evolved loci. - Source: PubMed
Publication date: 2026/04/21
Song Janet H TGreenberg Michael EReich DavidWalsh Christopher A