CD95 Ligand antibody
- Known as:
- CD95 Ligand (anti-)
- Catalog number:
- 10r-6576
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- CD95 Ligand antibody
Related genes to: CD95 Ligand antibody
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 Ligand antibody
Related articles to: CD95 Ligand antibody
- Vitamin D and marine-derived long-chain n-3 (omega-3) fatty acids (FAs) may represent a novel intervention to prevent anemia of inflammation. We report the results of an ancillary study of the larger Vitamin D and Omega-3 Trial (VITAL), which looked at the effect of vitamin D and/or omega-3 FA supplementation on incidence of anemia in midlife and older adults. VITAL is a randomized, double-blinded, placebo-controlled trial, with a 2 × 2 factorial design. We focus on a subcohort of 839 participants without baseline anemia evaluated at the Boston Clinical and Translational Science Center. The primary end point was incidence of anemia (hemoglobin <13 g/dL for men, and <12 g/dL for women measured, at 2 years). The secondary end point was change in hemoglobin from baseline to 2 years. Incidence of anemia in our cohort was 9.3% over 2 years. Neither vitamin D nor omega-3 FAs had significant effect on anemia incidence (odds ratio [OR], 0.94 [95% confidence interval (CI), 0.59-1.51] and 1.31 [95% CI, 0.82-2.09], respectively) or change in hemoglobin from baseline to 2 years. There were no significant differences when stratified by race, sex, body mass index, or baseline vitamin D level. Omega-3 FAs had a statistically significant effect on change in hemoglobin in participants with baseline C-reactive protein >3 mg/L ( interaction = 0.047), whereas vitamin D had an effect in participants with lower than median baseline total fish intake ( interaction = .001). Supplementation with vitamin D or omega-3 FAs, or their combination, did not reduce incidence of anemia in midlife and older adults. The trial was registered at www.ClinicalTrials.gov as #NCT01169259. - Source: PubMed
Publication date: 2025/12/09
Cho Hae LinLi ChunyingManson JoAnn ECook Nancy RLee I-MinBuring Julie EBerliner Nancy - Elevated saturated fatty acids (SFAs) have generally been associated with higher cardiovascular risk, whereas emerging evidence suggests that long- and very-long-chain SFAs (LVLSFAs) may be inversely associated with cardiometabolic outcomes. - Source: PubMed
Publication date: 2026/08/05
Ramezankhani AzraHadaegh PartoAbiri BehnazHadaegh Farzad - In natural environments, animals must detect behaviorally relevant odors despite variability in both odor mixture composition and stimulus intensity. Although mice can identify salient odors embedded in complex mixtures, how target concentration and background complexity jointly constrain discrimination remains unclear. We trained mice in a two-alternative forced choice task to identify target odors embedded in mixtures containing up to 16 background components. After performance stabilized, we systematically varied target odor concentration. Discrimination accuracy declined with decreasing target concentration but showed little additional dependence on background complexity. Using a biophysically grounded model of olfactory bulb glomerular responses, we show that linear decoding reproduces behavioral performance when intrinsic neural noise dominates over background-driven variability. Manifold capacity analysis revealed that neural representations remain efficiently structured for odor discrimination despite variation in background complexity. These results define a noise-limited regime of olfactory discrimination in which target detectability is primarily constrained by neural sensitivity rather than background interference. - Source: PubMed
Publication date: 2026/08/20
McCalmon HannahCai GeorgeTsibouris ConstantineHamou NoéHoskins JoPashakhanloo FarhadChung SueYeonKapoor VikrantMurthy Venkatesh N - Fatty acids (FAs) play critical neurodevelopmental roles, yet associations with executive function among children affected by perinatal HIV remain poorly characterized. This prospective cohort study examined associations between serum FAs and caregiver-reported executive function and evaluated effect modification by perinatal HIV status among 6-10-year-old Ugandan children who had perinatal HIV infection (CPHIV; n = 84), were HIV exposed but uninfected (CHEU; n = 78), or were HIV unexposed and uninfected (CHUU; n = 81). Serum FAs were measured at enrollment, and executive dysfunction was assessed at enrollment, 6, and 12 months (Executive Functioning Index (EFI) and Global Executive Composite (GEC)). Multivariable linear mixed models estimated overall and HIV-specific mean differences (MDs) and 95% confidence intervals (CIs) in executive dysfunction z-scores by FA tertiles. Moderate versus low arachidonic acid (MD [95% CI] EFI: -0.40 [-0.71, -0.09]; GEC: -0.30 [-0.58, -0.03]) and highly unsaturated FAs (HUFAs; EFI: -0.41 [-0.72, -0.11]) associated with lower executive dysfunction. Among CPHIV, high Mead acid (20:3 (n-9)) associated with higher executive dysfunction (EFI: 0.56 [0.11, 1.01]). Among CHEU, lower executive function was associated with high docosatetraenoic acid (EFI: -0.93 [-1.71, -0.15]) and docosahexaenoic acid (GEC: -0.78 [-1.26, -0.31]). These results showed that higher HUFAs associated with better executive function, particularly among CHEU, supporting further nutritional intervention research for children affected by perinatal HIV. - Source: PubMed
Cardino Vanessa NGiordani BrunoSikorskii AllaZalwango Sarah KFenton Jenifer IEzeamama Amara E - BackgroundChronic Achilles tendon rupture (CATR) is a debilitating condition affecting activities such as walking and jumping. Surgical reconstruction remains preferred for larger defects, with local tendon transfers including the flexor hallucis longus (FHL) and peroneus brevis (PB). However, these techniques carry risks of donor-site morbidity and neurovascular injury, particularly in high-risk patients.ObjectivesThis article describes a novel minimally invasive endoscopic technique and reports 3 cases of CATR reconstruction using peroneus longus (PL) tendon transfer as an alternative.MethodsThis technique employs standard posterolateral and posteromedial hindfoot portals without requiring additional peroneal tendoscopy portals. A small incision is made near the calcaneocuboid joint to perform tenodesis between PB and PL tendons, with the foot in maximum eversion to maximize tendon harvest. The PL tendon is then pulled through the posterolateral portal with the aid of the tag sutures, then passed through a calcaneal tunnel, and secured using an interference screw under fluoroscopic guidance.ResultsThe procedure was performed in 3 patients with complete CATR (2 insertional, 1 noninsertional). At 1-year follow-up, all patients demonstrated clinical improvement in American Orthopaedic Foot & Ankle Society (AOFAS) and Achilles tendon Total Rupture Score (ATRS) measurements, with no gross clinical weakness in ankle eversion or lateral instability. One patient developed localized plantar heel hypoesthesia, while no major neurovascular complications or lateral ankle instability were observed.ConclusionEndoscopic PL transfer was feasible in 3 patients with CATR and was associated with improved short-term clinical scores. This technique may be considered a potential alternative or salvage option when FHL transfer is unsuitable. However, larger comparative studies are needed before definitive conclusions can be made regarding this technique.Levels of Evidence:. - Source: PubMed
Publication date: 2026/08/21
Saleh AhmedHawila Ahmed MaherEltabbaa Ayman Youssef