OX40 Ligand antibody
- Known as:
- OX40 Ligand (anti-)
- Catalog number:
- 10r-6575
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- OX40 Ligand antibody
Related genes to: OX40 Ligand antibody
- Gene:
- TNFRSF4 NIH gene
- Name:
- TNF receptor superfamily member 4
- Previous symbol:
- TXGP1L
- Synonyms:
- ACT35, OX40, CD134
- Chromosome:
- 1p36.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-15
- Date modifiied:
- 2019-04-23
Related products to: OX40 Ligand antibody
Related articles to: OX40 Ligand antibody
- Hepatocellular carcinoma (HCC) is a highly malignant and aggressive tumor. Immune-related genes (IRGs) expression correlates closely with the HCC immune microenvironment, and this study aims to identify immune-related diagnostic markers in HCC. - Source: PubMed
Publication date: 2026/04/30
Li WeiJiang HangDuan JianHe JinlanZhao LipingZhong GuopingFan Chenghu - Lung Squamous Cell Carcinoma (LUSC), a common subtype of non-small cell lung cancer, primarily occurs in elderly individuals and is closely linked to senescence-related biological processes. Meanwhile, senescence reshapes the tumor microenvironment by promoting immune suppression and angiogenesis, and its underlying mechanisms remain unclear. Here, we identified three senescence-related molecular subtypes of LUSC, each with distinct clinical outcomes, genomic alterations, and immune features. Among them, Cluster 1 was associated with poor prognosis, increased genomic instability, and an immunosuppressive TME enriched with senescence signatures. To uncover the underlying mechanisms, we integrated bulk and single-cell transcriptomic data and found extensive senescence reprogramming across epithelial, myeloid, and T/NK cell compartments. Notably, senescent immune subsets-such as S100A9 + macrophages and TNFRSF4 + Tregs-were markedly enriched in older patients. Furthermore, cell communication analysis revealed enhanced intercellular signaling in senescent cells. Based on these findings, we constructed a robust machine learning-based prognostic model incorporating senescent gene expression and cell-type abundance to predict survival and immunotherapy response. Finally, functional validation demonstrated that UGT1A7 acts as a pro-proliferative driver that is significantly downregulated during the induction of cellular senescence. Experimental depletion of UGT1A7 phenocopies this senescence-associated decline, thereby triggering growth arrest and inhibiting tumor progression, suggesting its potential as a therapeutic target. Our study reveals how senescence-related alterations in cellular composition and transcriptional dysregulation reshape the tumor microenvironment, providing novel biomarkers and a theoretical basis for therapy. - Source: PubMed
Publication date: 2026/07/08
Mao ShengqiangDeng TongLiu ZhiqiangDing RenxinLi LeiLin Yidan - Recurrent pregnancy loss (RPL) is characterized by two or more consecutive pregnancy losses, often associated with genetic, immunological, endocrine, and anatomical abnormalities. Among these, chromosomal abnormalities, including aneuploidies and submicroscopic copy number variations (CNVs), play a critical role in adverse pregnancy outcomes. A total of 125 fetal specimens were collected, of which 118 were included after applying predefined exclusion criteria. DNA isolated from products of conception and fetal tissues was subjected to quantitative fluorescent PCR (QF-PCR) for rapid aneuploidy screening. A subset of 30 samples with selected QF-PCR outcomes underwent array comparative genomic hybridization (aCGH). Identified CNVs were interpreted according to ACMG/ClinGen guidelines, followed by bioinformatics analyses using FunRich, WebGestalt, KEGG, and STRING to explore functional annotations and pathway enrichment. Among 118 samples, QF-PCR identified aneuploidy in 36 cases (30.5%), including monosomy (n = 20) and trisomy (n = 16), while 82 cases were reported as normal. Maternal age showed a significant association with chromosomal abnormalities (p < 0.05), and a weak negative correlation was observed between gestational age and aneuploidy risk (r = - 0.238, p = 0.008855). In the aCGH cohort (n = 30), clinically relevant CNVs were identified, including pathogenic and likely pathogenic variants, as well as variants of uncertain significance (VOUS). Notably, genes such as CFHR3, TNFRSF4, UGT2B17, CD24, MSR1, and the PSG gene family were implicated. Functional enrichment analysis revealed involvement in immune-inflammatory pathways, endocrine regulation, lipid metabolism, extracellular matrix remodeling, and placental development. This study demonstrates the enhanced diagnostic utility of combining aCGH with QF-PCR for identifying chromosomal abnormalities in RPL. However, the observed associations between CNVs and biological pathways are exploratory in nature and require validation in larger, well-powered cohorts. - Source: PubMed
Publication date: 2026/06/30
Mishra ShivaniAshish AshishRai SangeetaYadav Abhay KumarSingh Royana - The OX40/OX40L axis entered clinical development in atopic dermatitis with a strong biological rationale and early signs of durable activity. However, as the treatment landscape evolved, questions emerged about whether the magnitude of monotherapy benefit was sufficient relative to established and emerging therapies. The discontinuation of rocatinlimab after confirmed and suspected cutaneous Kaposi's sarcoma cases, together with two cumulative cases reported in the amlitelimab program in patients with known risk factors, has changed the discussion from early promise to mechanism, risk, and therapeutic strategy. Although a causal link between OX40/OX40L modulation and Kaposi's sarcoma remains unproven, available human genetic and experimental observations make the association biologically plausible but mechanistically unresolved. The central challenge is now to determine how the axis can be targeted, in which patients, and in what therapeutic context, to maximize clinical benefit while managing risk. Rather than signaling the end of the axis in atopic dermatitis, Kaposi's sarcoma may instead mark the limits of a first-generation development strategy and the beginning of a more selective approach built around molecule design, therapeutic context, and prospective risk mitigation. - Source: PubMed
Publication date: 2026/06/02
Salek-Ardakani Shahram - Cardiac allografts show poorer long-term survival and decreased tolerance compared to renal allografts, but the underlying mechanisms remain unclear. - Source: PubMed
Publication date: 2026/06/05
Li PeiyuanChang YuanZhu XiaofeiChen XiaoHua XiumengSheng YixuanZhang NingningZhao QianXing KaiDu XingchaoXu MengdaSong Jiangping