Ask about this productRelated genes to: CD277 antibody
- Gene:
- BTN3A1 NIH gene
- Name:
- butyrophilin subfamily 3 member A1
- Previous symbol:
- -
- Synonyms:
- BT3.1, BTF5, CD277, BTN3.1
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-27
- Date modifiied:
- 2016-10-05
Related products to: CD277 antibody
Related articles to: CD277 antibody
- Anti-GD2 monoclonal antibody effectively treats high-risk neuroblastoma (HR-NB) by recruiting NK cells for antibody-dependent cellular cytotoxicity (ADCC). We recently developed a cell product containing mature, cytotoxic γδ T and NK cells (GADEKILL), and its potential use as a novel immunotherapy for HR-NB has been investigated. - Source: PubMed
Publication date: 2026/01/30
Morandi FabioDella Lastra MartinaPastorino FabioCiampi EleonoraFaraci MauraBrignole ChiaraGiardino StefanoAiroldi Irma - Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health threat. γδ T cells, critical innate immune responders, provide rapid anti-TB defenses and act as a bridge between innate and adaptive immunity. Studies have demonstrated that γδ T-cell activation by phosphoantigens is mediated by butyrophilin subfamily 3 member A1 (BTN3A1), leading to enhanced cytokine production and cytotoxicity. Mtb heat-resistant antigen (Mtb-HAg), extracted from Mtb H37Ra, specifically activates γδ T cells and induces cytokine secretion. However, the contribution of Mtb-HAg to γδ T cell-mediated cytotoxicity and its dependence on BTN3A1 remain unclear. - Source: PubMed
Publication date: 2026/01/28
Song YaminGuo FangzhengDai HuitingZhou XiaoyuDong SihangZhang HuiQian ZhongqingLi BaiqingWang XiaojingXu TaoWang Hongtao - γδ T cells maintain intestinal immune homeostasis, but their contributions to human ulcerative colitis (UC) are poorly understood. We characterized γδ T cells in intestinal biopsies obtained from patients with UC and healthy donors using single-cell RNA sequencing, T cell receptor profiling, and mass cytometry. UC reduced CD103Vγ4Vδ1 γδ intraepithelial lymphocytes (γδ IELs) and increased γδ T cell subsets with stemlike phenotypes expressing TCF-1 (T cell factor 1) and PD-1 (programmed cell death receptor 1) or effector-like phenotypes expressing granzyme B, perforin, and T-bet in the lamina propria. γδ T cell composition changes in UC correlated with decreased expression of epithelial and and increased and , suggesting altered recruitment and activation. Clinical improvement recovered γδ IELs and reduced inflammation-associated subsets. Inflammation-associated changes were observed in peripheral blood γδ T cells. Thus, distinct γδ T cell subsets in different niches exert protective or pathogenic functions in UC. - Source: PubMed
Publication date: 2026/02/06
Mayer Lena SArnold JakobRoettele FelixReuter NadinePattekar AjinkyaOhtani TakuyaRibeiro Mariana MSiwicki RebeccaBruder KerstinObwegs DavidStahl ElinBuechel SarahRoehlen NataschaKolter JuliaMansoori Moghadam ZohrehAlaswad AhmedZhumalidova ZhibekLi GuangLiu XinjuanLi YangSingh AmitVillacorta Hidalgo JoseParaskevopoulou Maria DYajnik VijayJuarez JuliusRen YueLi HongzheWherry E JohnLewis James DWu Gary DBewtra MeenakshiTomov Vesselin TThimme RobertBengsch BertramHasselblatt PeterPicelli SimoneHofmann MaikeSagar - Phosphoantigens (pAgs) are phosphate-containing small molecules that elicit an immune response. The pAgs bind to the intracellular domain of butyrophilin 3 (BTN3), enabling interactions with other butyrophilins to form complexes that trigger the T cell receptor (TCR) of Vγ9Vδ2 (γ9δ2) T cells. Despite multiple reports on this process, the conditions that regulate pAg levels leading to their detection remain unclear. Here we reveal a novel stress detection pathway, a type of lymphoid stress-surveillance response, in which mild cold stress triggers endogenous pAgs to engage with BTN family proteins, leading to the activation of γ9δ2 T cells. This stress response is dependent upon endogenous pAgs, as inhibition of HMG-CoA reductase abrogates the effect. It is also dependent upon BTN proteins, as depletion of BTN3A1 reduces the response. The ability of BTN2A1/BTN3A1 to respond is enhanced by the presence of BTN3A2 or BTN3A3. Furthermore, the internal domains of BTN2A1, BTN3A1, and BTN3A3 display differing abilities to dimerize, with BTN2A1 a constitutive dimer, BTN3A1 a monomer, and BTN3A3 a concentration dependent dimer. Full length BTN2A1/3A1 hybrid proteins additionally reveal that appropriately spaced multimers of BTN2A1 and BTN3A1 are critical in engaging the γ9δ2 TCR. In summary, our study uncovers a novel γ9δ2 T cell activation pathway mediated by cell stress and mevalonate pathway intermediates and highlights the critical roles of the BTN family members and their spacing in this process. - Source: PubMed
Publication date: 2026/01/22
Jin YimingNguyen KhiemBashir SidraPawge GirijaStrand Reagan MHsiao Chia-Hung ChristineVinogradova OlgaWiemer Andrew J - Diabetic neuropathy (DN) is a progressive disorder with limited effective treatment options. - Source: PubMed
Ding Xue-FengDang XinLin Shan