Ask about this productRelated genes to: CD160 antibody
- Gene:
- CD160 NIH gene
- Name:
- CD160 molecule
- Previous symbol:
- -
- Synonyms:
- BY55, NK1, NK28
- Chromosome:
- 1q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-02
- Date modifiied:
- 2016-10-05
Related products to: CD160 antibody
Related articles to: CD160 antibody
- In multiple sclerosis (MS), T cells could contribute to disease in their attempt to control the Epstein-Barr virus (EBV). Here, we compared the presence of HLA-B7 (higher MS risk) or HLA-A2 (lower MS risk) and investigated the effector phenotype of EBV epitope-specific CD8 T cells in MS using spectral flow cytometry. In contrast to HLA-A2, HLA-B7-restricted CD8 T cells recognized few EBV epitopes. These HLA-B7-restricted EBV-specific CD8 T cells expressed CNS residency markers and were most abundant in postmortem CNS compartments of an HLA-A2B7 MS donor. HLA-B7-restricted EBV-specific CD8 T cells displayed a more exhausted phenotype (PD-1CD244CD160KLRG1TIGIT). In line with these findings, anti-EBNA1 IgG levels were elevated in patients with MS carrying HLA-B7 but lacking HLA-A2. These data support a model in which the confined response against EBV generates circulating HLA-B7-restricted CD8 T cells less able to control EBV and more prone to infiltrate the CNS. - Source: PubMed
Publication date: 2026/04/15
Reijm SanneMarques Ana MRip JasperCorsten Cato E AWierenga-Wolf Annet Fde Wit HarmMelief Marie-Josévan Hasselt Yifanvan Langelaar JamieNeuteboom RinzeWokke Beatrijs H AMueller Yvonne MSmolders Joostvan Luijn Marvin M - How gut microbiota alterations may contribute to host inflammation and metabolomic profiles affecting atherosclerosis is not fully elucidated, especially in the context of HIV. - Source: PubMed
Publication date: 2026/05/04
Wang ZhengWang YiPeters Brandilyn APost Wendy SBrown Todd TPalella Frank JRinaldo Charles RWitt Mallory DGange Stephen JKuniholm Mark HSha Beverly EChichetto Natalie EClish Clary BGerszten Robert EHodis Howard NSharma AnjaliAnastos KathrynBurk Robert DKaplan Robert CQi QibinHanna David B - To investigate the expression patterns of CD95 and CD160 on double-negative T (DN T) cells and their association with incomplete immune reconstitution in people living with HIV. - Source: PubMed
Publication date: 2026/04/16
Peng JingliLi YanyanXi JialeXia ZihaoLuo PingYang ShuoLu LianfengChen ChenCai RentianWang QinWei Hongxia - Natural killer (NK) cells play a pivotal role in anti-tumor immunity; however, the prognostic significance of genetic variants in NK cell-related genes in gastric cancer (GC) remains largely uncertain. - Source: PubMed
Publication date: 2026/04/15
Zeng GuangLu GuoqiangHu BeipingXu MidieLi GuanlinWang MengyunQiu LixinZhang RuoxinCheng LeiXu WanghongLiu XiaowenJin GuangfuLiu HongliangWei Qingyi - Preeclampsia is a multifactorial pregnancy complication characterized by hypertension and immune dysregulation, which can lead to adverse maternal and fetal outcomes. Decidual immune cells are critical for pregnancy homeostasis, yet their functional abnormalities and mechanisms in preeclampsia remain poorly understood. Herein, we sorted decidua immune cells from preeclampsia patients for single-cell RNA sequencing to characterize cellular composition and functional heterogeneity. We delineated the immune cell landscape of the decidua in preeclampsia. A hallmark of decidual immune microenvironment in preeclampsia was the marked augmentation of cytotoxic activity. Both NK and T cells exhibited enhanced cytotoxic activity, characterized by the significant upregulation of cytotoxicity-associated genes. NK cells exhibited a differentiation predisposition toward a unique tissue-resident ITGAECD160 subset with heightened cytotoxic and chemokine gene expression. Cell-cell communication analysis further revealed strengthened interactions between NK cells and macrophages, with macrophage-derived SPP1 signals potentially contributing to the amplification of local cytotoxic responses. Collectively, this study provides a comprehensive single-cell analysis of cytotoxic immune changes at the maternal-fetal interface in preeclampsia, revealing enhanced cytotoxicity that may represent a key pathological mechanism. These insights may inform the development of diagnosis and therapeutic strategies targeting cytotoxic immune dysregulation in PE. - Source: PubMed
Publication date: 2026/04/16
Mu YueliLiu DongHe ZhuoxuWang JulinZhou WenjieChen HongqinZhou ShengpingFeng TingZhou RongLi Hong