Ask about this productRelated genes to: CD131 antibody
- Gene:
- CSF2RB NIH gene
- Name:
- colony stimulating factor 2 receptor beta common subunit
- Previous symbol:
- IL3RB
- Synonyms:
- IL5RB, CD131, betaGMR
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2017-07-12
Related products to: CD131 antibody
Related articles to: CD131 antibody
- IntroductionLupus nephritis (LN) is characterized by significant heterogeneity and a complex pathophysiology, which traditional methods struggle to fully resolve. Advanced multi-omics approaches are essential to disentangle its cellular and molecular drivers.MethodsWe employed an integrative strategy combining single-cell RNA sequencing (scRNA-seq) profiling of LN biopsies with large-scale bulk RNA-seq cohorts. We applied non-negative matrix factorization (NMF) to scRNA-seq data to define robust immune meta-programs and utilized CellChat to decode cell-cell communication networks. Leveraging these insights to overcome sample size limitations, we prioritized key pathways and developed 399 machine learning predictive models using bulk transcriptomics, validated on independent cohorts.ResultsScRNA-seq analysis revealed a distinct cellular landscape, including a rare population of plasmacytoid dendritic cells (pDCs) and an expanded population of CD56dimCD16 natural killer (NK) cells expressing high levels of IFN-γ and perforin, suggesting a role in inflammatory pathology. Macrophage subpopulation CM2 emerged as a central pro-inflammatory hub, potentially driving fibrosis via autocrine signaling and epithelial activation. We observed reduced Treg-B cell interactions, suggesting a regulatory collapse. Our machine learning models, based on innate immunity, circadian rhythms, apoptosis, and NF-κB signaling, achieved high diagnostic accuracy (AUC = 0.929 for innate immunity). Hub genes, including , , and , were confirmed to be upregulated in LN and correlated with clinical severity in external validation datasets. Molecular docking simulations suggested a potential structural basis for CYBB-dexamethasone interaction, providing a hypothesis for future verification.DiscussionThis study identifies CM2 macrophages and dysregulated pDC-NK axes as key drivers of LN. By bridging cellular interactomes with clinical predictive modeling, we provide a robust roadmap for precision detection and identifying potential therapeutic targets in LN. - Source: PubMed
Publication date: 2026/04/27
Mou LishaLu YingWu ZijingPu Zuhui - Non-small cell lung cancer (NSCLC), the most common type of lung cancer, stands as a leading cause of cancer-related mortality worldwide. Immunogenic cell death (ICD )enhances cancer therapy efficacy by inducing immune responses and reshaping the TIME. While ICD increases cytotoxic T lymphocyte infiltration and reduces immunosuppressive elements, the specific TIME subtypes associated with ICD in lung adenocarcinoma (LUAD) remain undefined. - Source: PubMed
Publication date: 2026/02/25
Yang ZhengzhengYang QianruLi ShujiaoHan RuiyangHe HaiqiuZhang RunzeLi HaimingLi YudongCheng PeiyuLiu Xiawei - Macrophage (M-), granulocyte (G-), and granulocyte-macrophage (GM-) colony-stimulating factors (CSFs) regulate myeloid cell function, yet their relative roles during inflammation remain poorly defined. To uncover how CSFs shape spatial immune niches in Crohn's disease, we performed Xenium single-cell spatial transcriptomics on ileal tissues, revealing cell-type-specific expression and source-target interactions for each CSF. GM-CSF, unlike M-CSF or G-CSF, was locally enriched in ulcerated regions where lymphocytes adjacent to macrophage aggregates signaled through STAT5 phosphorylation. To study functional consequences, we developed a csf2rb / zebrafish model of intestinal injury. Using this model, we found that loss of GM-CSF signaling exacerbated epithelial damage and inflammation, whereas recombinant human GM-CSF limited injury by restraining ILC1 expansion, sustaining ILC3 maintenance, and promoting IL-22 production. Cross-species single-cell analysis revealed conserved ILC gene modules and GM-CSF-dependent transcriptional networks linking lymphoid and myeloid populations. These findings establish GM-CSF as a critical spatial regulator of myeloid-lymphoid crosstalk and intestinal immune homeostasis in Crohn's disease. - Source: PubMed
Publication date: 2026/03/06
Morrison Joshua KSabic KsenijaMaskey NehaTalware SayaliHsu Nai-YunChasteau ColleenAslinger ElizabethHerb Jake TNayar ShikhaLevantovsky RachelTastad ChristopherMoss RachelSoto AlanGarcia-Barros MonicaNtunzwenimana JessyGlass MarielBao MichelleZhang JiayuHan HuajunStevens JaneTavares LorenaThin Tin HtweKhaitov SergeyGreenstein AlexanderBrody RachelChu JaimeMortha ArthurCho Judy HChuang Ling-Shiang - Sexual dimorphism is found in gene expression and polarization of macrophages in mammals but remains unclear in the ontogeny of tissue-resident macrophages. Remarkable sex differences are present in salivary glands and risks for a related autoimmune disease, Sjögren'sdisease. Macrophages are the most abundant immune cells in healthy mouse salivary glands and essential for the maintenance of immune quiescence and tissue repair after radiation or inflammatory damages. Therefore, we compared the origins of macrophages in salivary glands between male and female mice using conditional Cx3cr1 and Ccr2 lineage-tracing approaches. We found that among salivary gland macrophages in adult mice, most are locally maintained and derived from yolk sac progenitors or perinatal monocytes in males, but much more are short-lived and continuously replenished by monocytes in females. In wild type C57BL/6 mice, female adult submandibular glands (SMGs) consistently contain more leukocytes, including classical monocytes expressing Ccr2, Ly6c, or Csf2rb and macrophages carrying these monocyte markers, as compared with male SMGs. Single-cell RNA sequencing and flow cytometry indicated that female SMG macrophages are more polarized and express several proinflammatory genes at higher levels. Meanwhile, female SMGs contain more innate lymphoid cells and T/NKT cells expressing and other proinflammatory cytokines. The potential contributions of these sexual differences warrant further studies as they relate to Sjögren's disease, the most female-dominant autoimmune disease, characterized by chronic inflammation in salivary and lacrimal glands. Also, these differences need be considered in developing macrophage-targeting therapies of dry mouth caused by autoimmunity or radiation. - Source: PubMed
Publication date: 2026/02/11
Zhao QPan SJaiswal JZhang LWang L-TChang EShahsavari AZhang YYu VZheng RChen TLiu F - This study investigates the pathogenesis of Pigmented Villonodular Synovitis (PVNS) using bioinformatics approaches shared with atherosclerosis (AS). - Source: PubMed
Publication date: 2026/02/06
Chen ShuilinJia HongleiZheng GuihaoLu MeifengOuyang YulongFan XiangweiSun Guicai