Ask about this productRelated genes to: CD123 antibody
- Gene:
- IL3RA NIH gene
- Name:
- interleukin 3 receptor subunit alpha
- Previous symbol:
- -
- Synonyms:
- CD123
- Chromosome:
- Xp22.3 and Yp13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-28
- Date modifiied:
- 2015-12-11
Related products to: CD123 antibody
Related articles to: CD123 antibody
- There are many studies about the correlation between Bataknese and schizophrenia patients, one of the most common ethnic in Indonesia. Cytokine and its’ receptor disorder is one of the scope of immunology research in schizophrenia. Interleukin 3 (IL-3) is an important cytokine with various biologic roles in immune response. We would like to determine the association between the polymorphism of IL3RA gene with negative symptoms in Bataknese schizophrenia patients. - Source: PubMed
Publication date: 2026/02/27
Asrika Asrul DikaEffendy ElmeidaMahmud Amin MustafaCamellia VitaYamamoto Zulham - Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by profound molecular heterogeneity and high relapse rates, posing significant clinical challenges. Programmed cell death (PCD), encompassing diverse regulated modalities such as apoptosis, necroptosis, and ferroptosis, plays a key role in leukemogenesis and therapeutic response; however, a comprehensive prognostic framework integrating multi-modal PCD pathways in AML remains elusive. In this study, we performed a systematic transcriptomic analysis of 1624 genes associated with 13 distinct PCD forms. A novel computational pipeline combining a variational autoencoder (VAE) for dimensionality reduction and a multilayer perceptron (MLP) for classification was employed to identify robust PCD-related biomarkers, interpreted via SHapley Additive exPlanations (SHAP) analysis. This approach identified 48 candidate genes with discriminative potential between AML and normal bone marrow. Unsupervised consensus clustering based on these genes delineated two molecular subtypes exhibiting divergent clinical outcomes and immune microenvironment profiles. The subtype demonstrated an immunosuppressive phenotype, characterized by enriched regulatory T cells, M2 macrophages, and elevated expression of inhibitory immune checkpoints, correlating with inferior survival. We developed an 8-gene prognostic signature (, , , , , , and ) that effectively categorized patients into high- and low-risk groups with notable survival differences, validated across independent cohorts. A prognostic nomogram combining the risk score, age, and cytogenetic risk enhanced the prediction accuracy for overall survival. Our study presents an integrative model that connects multi-modal PCD pathways to AML prognosis, offering a new molecular subtyping system and a clinically applicable risk assessment tool for improved prognostication and personalized treatment strategies. - Source: PubMed
Publication date: 2026/03/27
Zhang ChunlongNi HaisenZhao ZiyiZhao Ning - Ultraviolet B (UVB) irradiation is a key exogenous factor contributing to skin photoaging. Idebenone (IDE), a structural analog of coenzyme Q10 (CoQ10), exhibits potent free radical scavenging capacity and is mainly employed in the treatment of neurodegenerative disorders, and in anti-aging products. However, the molecular mechanisms underlying its photoprotective effects in skin cells remain poorly understood. - Source: PubMed
Publication date: 2026/03/19
Feng LiweiTian LinjieGuo JingZhang LinglingWang PengBu Xiaolin - High-grade gliomas (HGG) are aggressive central nervous system tumors with poor outcomes; in fact, only a small subset of patients survive beyond 5 years. - Source: PubMed
Publication date: 2026/03/17
Patanè MAbballe LPatrizi SCanale MCiolfi APedace LAntonacci CVinciarelli FLazzarini ETartaglia MCapelli LChiadini ECalistri DLocatelli FPollo BIndraccolo SAnghileri EMiele E - Estrogen receptor-positive (ER) breast cancer, a leading cause of female cancer mortality, faces therapeutic challenges due to endocrine resistance. Plasma proteins, bridging genetic variation and disease phenotypes, offer potential biomarkers and therapeutic targets, yet their causal roles in the pathogenesis of ER breast cancer remain underexplored. - Source: PubMed
Publication date: 2026/03/05
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