Ask about this productRelated genes to: CD117 antibody
- Gene:
- KIT NIH gene
- Name:
- KIT proto-oncogene, receptor tyrosine kinase
- Previous symbol:
- PBT
- Synonyms:
- CD117, SCFR, C-Kit
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CD117 antibody
Related articles to: CD117 antibody
- Hepatic stellate cell (HSC) activation is a key mediator in hepatic fibrosis, with glycolysis serving a key regulatory function. S100 calcium-binding protein 16 (S100A16) has been associated with various pathologies; however, its function and underlying mechanisms in liver fibrosis remains elusive. This study aimed to elucidate the functional role of S100A16 in HSC activation and its interaction with Erb-B2 receptor tyrosine kinase 2 (ERBB2)-mediated glycolysis. Transforming growth factor-β1 (TGF-β1)-stimulated human liver stellate cells (LX2) and carbon tetrachloride (CCl)-induced mice were used as in vitro and in vivo models, respectively. Cell proliferation and alpha-smooth muscle actin (α-SMA) expression were detected by Cell Counting Kit-8 (CCK-8) assay and immunofluorescence. Glycolysis was detected via measuring the extracellular acidification rate (ECAR), lactate production, glucose uptake, and glycolytic enzyme levels. Molecular interactions were analyzed through bioinformatics and co-immunoprecipitation. Liver injury and fibrosis were assessed using hematoxylin and eosin (H&E)/Masson staining. Expression of S100A16, ERBB2, and fibrosis markers were quantified using quantitative real-time PCR (qRT-PCR) and Western blot. S100A16 was upregulated in fibrotic liver tissues and TGF-β1-stimulated LX2 cells. TGF-β1 increased lactate production and glycolysis, whereas S100A16 knockdown produced the opposite effects. Additionally, TGF-β1 enhanced cell proliferation and upregulated α-SMA, Collagen 1, and Fibronectin levels, but these effects were attenuated by either S100A16 knockdown or glycolysis inhibition. S100A16 interacted with ERBB2 and promoted its expression. ERBB2 knockdown reduced TGF-β1-induced glycolysis and HSC activation, along with reduced cell proliferation, effects that were inhibited by S100A16 overexpression. Furthermore, S100A16 knockdown ameliorated CCl-induced liver injury and fibrosis, decreased serum lactate levels, and reduced S100A16 and ERBB2 expression, thereby suppressing glycolysis. Collectively, S100A16 promotes HSC activation and liver fibrosis through ERBB2-mediated glycolysis, highlighting the S100A16-ERBB2-glycolysis axis as a potential therapeutic target. - Source: PubMed
Ou ShiyuTang XiaolingLiu JuanOuyang RongHuang ShijiangWeng ShuwenQin JinpingLiang DinghengDu LingLi Zhongzhuan - The separation of C2H2 from CO2 remains a critical challenge because of their similar molecular dimensions and boiling points. Herein, we report two isostructural cage-based metal-organic frameworks (MOFs), LIFM-801 and LIFM-802, with Co and Ni metal nodes. Built from linear trinuclear metal nodes and tritopic pyridyl ligands, both adopt a nested cage architecture. Cage-confined tetrafluoroborate (BF4-) counteranions are immobilized within cavities via C-H···F interactions, generating fluorine-rich microenvironments as C2H2 recognition sites. At 298 K and 1 bar, LIFM-801 and LIFM-802 exhibit C2H2 uptakes of 121.4 and 113.5 cm3 g-1 with isosteric adsorption enthalpies (Qst) of 30.1 and 27.8 kJ mol-1. Ideal adsorbed solution theory (IAST) calculations yield equimolar C2H2/CO2 selectivities of 4.17 and 2.96. Dynamic breakthrough experiments demonstrate efficient C2H2/CO2 separation performance with separation windows of 23 and 22 min g-1 at 298 K. The comparable performance indicates that the separation ability is dominated by cage-confined BF4- anions, while metal node substitution enables tuning of affinity and kinetics. Grand canonical Monte Carlo (GCMC) simulations corroborate that cage-confined BF4- serves as the dominant binding site for C2H2 via C-H···F interactions. This work highlights a guest-anion confinement strategy for fluorine-rich adsorption microenvironments toward gas separations, with metal node modulation for performance optimization. - Source: PubMed
Zhou Zi-QianGuo Ya-NanSong LiangZhu Xiao-YanFenske DieterFan Ya-NanJiang Ji-JunChen Cheng-XiaWei Zhang-WenSu Cheng-Yong - To investigate the genetic etiology of a three-generation pedigree affected with piebaldism. - Source: PubMed
Publication date: 2026/09/05
Yan KaiWang LiyaPan JiexueHuang HefengDong Minyue - WD repeat and SOCS box containing protein 1 (WSB1) promotes tumor progression and metastasis; however, its role in the response to hyperthermia combined with chemoradiotherapy in cervical cancer remains unclear. Therefore, this study investigated the involvement of WSB1 and the c-Myc/Wnt/β-catenin axis in the antitumor effects of this combined treatment. - Source: PubMed
Publication date: 2026/09/07
Bai LuLi FengLiu ShashaShi FangyuCui PenghuaYang JiyuanLi QingshanLiu Ming - Introduction Orbital compartment syndrome is a rare but sight-threatening ophthalmic emergency requiring immediate recognition and intervention to prevent irreversible vision loss. Emergency lateral canthotomy and cantholysis remain the definitive treatment; however, the infrequent nature of the procedure means many ophthalmologists have limited practical experience and reduced procedural confidence. In addition to technical familiarity, delays in treatment may arise from difficulties locating emergency equipment within clinical environments. This quality improvement project evaluated clinician preparedness for the management of orbital compartment syndrome within a UK National Health Service (NHS) ophthalmology department and assessed the impact of introducing standardised emergency lateral canthotomy grab kits alongside focused educational teaching. Methods A single-centre closed-loop quality improvement project was undertaken within a UK NHS ophthalmology department. Clinicians of varying grades completed a baseline questionnaire assessing confidence in recognising orbital compartment syndrome, performing emergency lateral canthotomy, and locating the equipment required to undertake the procedure under time-critical conditions. Following baseline assessment, two interventions were implemented: a focused departmental teaching session reviewing recognition and management of orbital compartment syndrome and a dedicated emergency lateral canthotomy grab kit containing all equipment required for orbital decompression. A repeat survey was undertaken following implementation to evaluate changes in clinician preparedness, procedural confidence, and perceived accessibility of emergency equipment. Results Baseline findings demonstrated variable confidence in performing emergency lateral canthotomy and highlighted uncertainty regarding the location of essential equipment. Following implementation of the educational intervention and emergency grab kit, clinicians reported improved preparedness and procedural confidence. Around 92% of participants agreed that the introduction of dedicated grab kits improved procedural efficiency and accessibility, while all respondents reported being able to identify the equipment required to perform emergency lateral canthotomy following implementation. Conclusion This quality improvement project demonstrated that simple, low-cost interventions can improve clinician preparedness for the management of orbital compartment syndrome. Combining focused education with standardised emergency equipment may reduce avoidable delays during time-critical ophthalmic emergencies and represent an easily reproducible intervention that could be adopted across ophthalmology departments nationwide to improve the management of orbital compartment syndrome. - Source: PubMed
Publication date: 2026/09/06
Awad PeterAwad MarkAwad John