Ask about this productRelated genes to: CD117 antibody
- Gene:
- KIT NIH gene
- Name:
- KIT proto-oncogene, receptor tyrosine kinase
- Previous symbol:
- PBT
- Synonyms:
- CD117, SCFR, C-Kit
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CD117 antibody
Related articles to: CD117 antibody
- Cerebral ischemia-reperfusion injury (CIRI) triggers endoplasmic reticulum stress (ERS), a key pathological driver of neuronal apoptosis and neurological impairment. While the neuroprotective effects of astragaloside IV (AS-IV) are well-documented, the precise regulatory bridge between the Sonic Hedgehog (SHH) pathway and ERS remains to be elucidated. - Source: PubMed
Publication date: 2026/09/18
Wei PingboHan YangyunWang JunLuo LeMeng JiangFan BoLiu Jiaxin - Gantry-less radiotherapy with a fixed treatment beam, in which an upright patient is slowly rotated, promises reductions in treatment room costs and could offer anatomical / comfort benefits for certain patients. Several radiotherapy centres worldwide have now designed or acquired upright patient immobilization systems; however, many aspects of the upright treatment workflow are yet to be fully addressed. - Source: PubMed
Publication date: 2026/09/18
Trnkova PetraUnderwood TracyBokrantz RasmusEngwall ErikGlide-Hurst CarriGaribaldi CristinaGlimelius LarsInaniva TakuJäkel OliverJolly SimonLomax TonyMartire Maria ChiaraPatera VincenzoPlacidi LorenzoPryanichnikov AlexanderRinaldi IlariaSands GordonTroost Esther G CVai AlessandroZhang YeVolz Lennart - Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for pesticide detection but is hindered in field applications by slow analyte mass transport and quantitative irreproducibility. Herein, we report an in-tube solid-phase microextraction-SERS (in-tube SPME-SERS) strategy that simultaneously overcomes these bottlenecks. A silver-nanoplate-decorated copper wire was synthesized via galvanic replacement, functionalized with thiocyanate (SCN) as a covalently bonded internal standard (IS), and assembled into a fused-silica capillary. Hydrodynamic flow compresses the diffusion boundary layer, accelerating the extraction equilibrium from ∼90 min (static mode) to ∼300 s. The SCN internal standard (2136 cm) enables ratiometric correction (I/I) for thiram quantification, effectively compensating for substrate heterogeneity and instrumental drift. Mechanistic studies reveal a competitive adsorption process where thiram partially displaces SCN, ensuring precise analyte-IS co-localization. This method exhibits excellent analytical performance for thiram, including a wide linear range (20-1000 nM), a low limit of detection (33.8 nM), and high reproducibility (RSD < 10%). Furthermore, direct analysis of surface and groundwater samples without pretreatment yields satisfactory recoveries (90.9%-108.5%). With robust 28-day stability, this ratiometric in-tube SPME-SERS platform provides a reliable, kit-based solution for on-site environmental monitoring. - Source: PubMed
Publication date: 2026/09/15
Xin YuxuanYang ZixiaoLiu RubingGai YinanWang WeiLai Yongchao - - Source: PubMed
Publication date: 2026/09/16
Nickel AnninaReinhardt AndréLachmann Ingolf - Maternal diabetes mellitus (DM) is a known risk factor for offspring metabolic dysfunction, predisposing them to DM later in life. While this association is established, the molecular mechanisms underlying the intergenerational transmission of DM risk are not fully understood. This study investigated the effects of in utero exposure to maternal DM on circulating levels of asprosin in offspring, aiming to clarify the potential role of asprosin in this pathological cascade. Twelve pregnant Wistar rats were randomized into two groups: a streptozotocin (STZ)-induced diabetic group (n = 6) and a non-diabetic control group (n = 6). DM was confirmed via blood glucose measurements (>250 mg/dL) 72 hours post-STZ administration. At 16 weeks postnatal, six male offspring per group were euthanized for plasma collection. Asprosin levels were measured using a commercial ELISA kit. Statistical analyses were performed to compare group means and determine the relationship between asprosin and variables. Maternal asprosin levels were significantly higher in the DM group compared to controls (330.70 ± 78.13 vs. 244.00 ± 21.54 pg/mL, P = 0.02). However, offspring of both groups showed comparable circulating asprosin concentrations (234.50 ± 10.60 vs 235.00 ± 7.23 pg/mL, P = 0.92). In contrast to diabetic mothers, in whom asprosin was significantly correlated with atherogenic lipid parameters and glucose homeostasis indices, no significant correlations were observed between asprosin and these parameters in offspring of either group. These preliminary findings suggest that asprosin may not be a critical mediator in the intergenerational transmission of diabetes-associated metabolic dysfunction. - Source: PubMed
Publication date: 2026/09/18
Ahmadasadi HamidrezaRasouli Emamgholi PeymanLayali IssaKianfar TinaTork ShahriyarJafarpour MobinaAliabadi MasoumeHeydari Hafez