Ask about this productRelated genes to: CD117 antibody
- Gene:
- KIT NIH gene
- Name:
- KIT proto-oncogene, receptor tyrosine kinase
- Previous symbol:
- PBT
- Synonyms:
- CD117, SCFR, C-Kit
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CD117 antibody
Related articles to: CD117 antibody
- As a novel type of high-energy-density, environmentally friendly, and low-sensitivity energetic materials (EMs), cyclo-pentazolate salts are being extensively studied. However, their detonation mechanism remains unclear. This study developed a neural network potential (NNP) to simulate the shock-induced detonation process of NHOHN-, a representative salt of the pentazolate anion (N-). The well-trained NNP exhibits high precision comparable to DFT, as well as high efficiency. The NNP-based large-scale molecular dynamics (MD) simulations for NHOHN- produced an ideal C-J detonation velocity of 9.4 km/s, which is in agreement with the value estimated by the Cheetah 7.0 program (9.93 km/s). The simulation demonstrates that the proton transfer from NHOH to N- is the initial reaction, while the primary decomposition pathway of N- is a ring-opening reaction, or the bimolecular reactions with its initial decomposition intermediate azide anion N- resulting in the formation of N ring. Quantum chemical calculations show that these pathways possess low activation barriers. The influence of nuclear quantum effects on shock-induced chemical reactions was also studied, which shows that nuclear quantum corrections not only improve the accuracy of predicted ideal detonation velocity but also improve temperature in simulations, which results in the different reaction mechanism of shock-induced detonation reaction of NHOHN-, facilitating the ring-opening reaction of N- ring and preventing its reaction with N. This study enhances the understanding of the detonation mechanism of cyclo-pentazolate salts. - Source: PubMed
Publication date: 2026/05/07
Zhao JikaiZhang JidongZhang Weijing - The present study aimed to explore the therapeutic effects and underlying mechanisms of the active constituents of . in gastric cancer (GC) and to identify potential targets for its prevention and treatment. Active compounds and their corresponding targets were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. In comparison, GC-related targets were retrieved from GeneCards and Online Mendelian Inheritance in Man databases. Common targets were identified using Venny 2.1.0. Cytoscape 3.10.2 was then employed to construct a traditional Chinese medicine component-target-disease network and a protein-protein interaction network. Core compounds and targets were further assessed through molecular docking, and the potential mechanisms were investigated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The biological activity of luteolin, the principal active component of ., was experimentally validated in AGS cells using Cell Counting Kit-8 assays, wound-healing (scratch) assays, Transwell migration assays, flow cytometry and western blotting. A total of 10 active ingredients and 166 shared targets were identified. Among them, quercetin, luteolin and acacetin were identified as key bioactive constituents, whereas AKT serine/threonine kinase 1 (AKT1), TNF and hypoxia-inducible factor-1 (HIF-1A) were recognized as central targets. Molecular docking analysis revealed strong binding affinities between the core compounds and these targets. Enrichment analyses further indicated that the therapeutic effects of . may involve pathways related to oxidative stress, the phosphatidylinositol 3-kinase-protein kinase B signaling pathway, and the HIF-1 signaling pathway. Among the identified compounds, luteolin showed the most pronounced inhibitory effects on GC cells and was therefore selected for further mechanistic investigation. experiments demonstrated that luteolin significantly suppressed GC cell proliferation and migration, reduced AKT phosphorylation and HIF-1A expression, and did not induce apoptosis. These findings suggest that luteolin may exert its anti-GC effects primarily by modulating the AKT1/HIF-1A signaling axis. The present study provides experimental support for the therapeutic potential of -derived compounds and offers insights into novel molecular targets for GC treatment. - Source: PubMed
Publication date: 2026/04/27
Yu WeizhouNi XiaohuiWang JingXia WeiShen XinyaQiu FanChen Yuping - As COVID-19 continues to reemerge with new variants, it has become a persistent challenge to public health, causing disruptions in society and the economy. We report a facile photonic crystal-based aptasensor for the rapid visual detection of the receptor-binding domain (RBD) of the severe acute respiratory syndrome (SARS-CoV-2) spike (S) protein. Monodispersed polystyrene@poly(2-hydroxyethyl methacrylate-acrylic acid) [PS@poly(HEMA-AA)] core-shell microspheres were synthesized to fabricate a stimuli-responsive photonic crystal (RPC). The integration of the RBD target-specific aptamer into the poly(HEMA-AA) hydrogel network facilitated the development of a biosensor that enabled RPCs to selectively bind to the SARS-CoV-2 spike protein using coupling chemistry. The interaction between the RBD and a single-stranded DNA aptamer causes the hydrogel to expand, leading to a color change and a shift in the photonic bandgap (PBG). This phenomenon can be used to detect the RBD of the SARS-CoV-2 spike protein. The addition of the RBD of SARS-CoV-2-S-protein to the Apt-RPC aptasensor resulted in a rapid visual color shift from violet to green. The detection range of the developed aptasensor was estimated to be 100-1000 ng with excellent selectivity. Thus, the developed aptasensor offers distinct advantages over conventional detection methods. Our study also facilitates the development of a straightforward point-of-care self-testing kit that does not rely on toxic acrylamide-based chemicals. Furthermore, the sensor eliminates the need for complex sample preparation or signal amplification steps, making it a promising platform for point-of-care diagnosis. - Source: PubMed
Publication date: 2026/05/05
Mary Thomas MeghanaChandran Parvathy RLekshmanan LekshmiPeer Mohamed APillai Saju - Short tandem repeats (STRs) are highly polymorphic genetic markers with essential roles in forensic identification and paternity testing. Understanding the genetic diversity of STR loci in specific populations is crucial for accurate forensic applications. The aims of this study were to evaluate the genetic variation and forensic efficiency parameters for 15 autosomal STR loci in the southern region population of KSA. - Source: PubMed
Publication date: 2026/04/30
Alhatim HuseinMuthanna AbdulRahmanHakim Abdullah Muhammad NMohd Desa Mohd N - HIV remains a global health concern, disproportionately affecting men who have sex with men (MSM). Discrimination, stigma, and other barriers in healthcare settings are common issues for MSM in Malaysia, resulting in sub-optimal HIV testing and linkage to HIV prevention services. Thus, we created a clinic-integrated HIV prevention app called "JomPrEP" to scale up HIV prevention efforts among this vulnerable group. This study aimed to explore the perceived utility, appeal, and functionality of the JomPrEP app for MSM in Malaysia to improve access to HIV prevention services. - Source: PubMed
Publication date: 2026/05/04
Sujan Md Safaet HossainWickersham Jeffrey AKhati AntoineGautam KamalPaudel KiranAzwa IskandarAltice Frederick LTan Yee KeeSabri Nursahira Sahiba MohdCopenhaver Michael MShrestha Roman