Ask about this productRelated genes to: CD117 antibody
- Gene:
- KIT NIH gene
- Name:
- KIT proto-oncogene, receptor tyrosine kinase
- Previous symbol:
- PBT
- Synonyms:
- CD117, SCFR, C-Kit
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CD117 antibody
Related articles to: CD117 antibody
- Pancreatic tumors are characterized by a prominent desmoplastic stroma that can account for up to 90% of the tumor. Given the marked upregulation of CD44, a family of transmembrane glycoproteins, in pancreatic cancer-associated fibroblasts (CAFs), we investigated its role in regulating myofibroblastic and inflammatory CAF phenotypes. Conditional deletion of Cd44 in fibroblastic cells in Cd44;PdgfrβCreER mice significantly reduced tumor growth and was associated with a significant reduction in intratumoral regulatory T cells (T). Consistently, in human CAFs CRISPR/Cas9-edited to delete CD44, the fibroblasts' morphology changed drastically: CAFs lost their elongated phenotype and adopted a round shape, reflecting their inactivation. This was accompanied by a significant downregulation of activation markers, unresponsiveness to exogenous stimuli, and reduced contractile activity. Furthermore, CD44 ablation decreased extracellular matrix production and altered the immunomodulatory cytokine secretion, highlighting its role in both fibrosis and immune regulation. Finally, CD44-deficient CAFs exhibited a reduced capacity to suppress anti-tumor immune responses by failing to induce immunosuppressive programs in dendritic cells (DCs) and by increasing cytotoxic T cell (CTL)-mediated tumor cell killing. Collectively, we identify CD44 as a regulator of CAF activation and immunosuppressive function, linking stromal remodeling to immune evasion in pancreatic cancer and supporting CD44 as a potential therapeutic strategy to reprogram the tumor stroma and enhance anti-tumor immunity. - Source: PubMed
Publication date: 2026/08/15
Treffert Sven MátéHeneka Yvonne MadeleineMartin JulieGargano AlessandraLaunhardt LarissaAkilli ÖzlemStanganello ElianaAndrieux GeoffroyHoch DominiqueSonnentag Steffen JoachimMehner Lisa-MarieMunoz-Sagredo LeonelChrist MichelleOrian-Rousseau Véronique - Gliomas are highly aggressive primary brain tumors with a dismal prognosis. Temozolomide (TMZ) serves as the first-line chemotherapeutic agent for glioma patients. However, the clinical efficacy of TMZ is severely limited by the inevitable development of acquired chemoresistance, which ultimately leads to tumor recurrence and treatment failure. Unraveling the molecular mechanisms underlying TMZ resistance is therefore critical for improving glioma prognosis. This study aimed to identify key genes driving TMZ resistance and explore their underlying mechanisms to provide novel therapeutic targets for overcoming this clinical challenge. - Source: PubMed
Publication date: 2026/08/15
Fan YiYang HeYu Hai - To describe the geographic distribution of naloxone kits in Rhode Island using multiple measures of naloxone saturation to inform future naloxone distribution efforts. - Source: PubMed
Publication date: 2026/08/15
Shin JaejoonHallowell Benjamin DMarshall Brandon D LKrieger Maxwell SSt John Kristen - Presumptive tuberculosis refers to individuals who presents with symptoms or signs of suggestive active TB having at least one of these clinical manifestations (more than two weeks of, cough, fever, appetite loss, night sweating, chest pain, or weight loss). Although tuberculosis is both preventable and curable, it continues to cause millions of new infections and fatalities globally. With a national burden that ranks third in Africa and eighth globally, Ethiopia remains a high-burden country for tuberculosis. Tigray had 6700 confirmed tuberculosis cases in 2020, immediately before the war had started. War is an ideal condition for the spread of TB. This has happened in Tigray following the war. Therefore, this study aimed to assess a community-based presumptive tuberculosis among rural and urban residents after the conflict in Tigray region of Ethiopia. - Source: PubMed
Publication date: 2026/08/05
Hidru Hagos DegefaTsadik MacheTequare Mengistu HagaziBerhe Abadi KidanemariamAsgedom Akeza AwealomGebrekidan Gebregziabher BerihuWoldearegay Haftom GebrehiwotGebretnsae HailayRedae Gebru HailuMeles Gebrekiros GebremichaelEbrahim Mohamedawel MohamednigussBereket TedrosTesfau Yemane BerhaneGebretsadik Gebremedhin GebreegziabherBerhe Muzey GebremichaelDebesay Micheale HagosEsayas RieyeAmaha Mebrahtom HafteHagos Weldegerima GebremedhinKahsay HayelomWeldu Meresa Gebremedhin - The following study details the draft genome sequencing of a sp. ABR isolated from Kurseong soil. sp. ABR synthesizes cellulase, essential for the breakdown of plant biomass. It is a prospective supply of enzymes significant for digestion, particularly lignocellulases. Genomic DNA was extracted from a pure bacterial colony (expanded in liquid culture before extraction) with a QIAGEN Blood and Tissue Kit (QIAgen Inc., Canada). DNA sequencing was carried out on the Illumina HiSeq X platform employing 2 × 150 bp paired-end chemistry, yielding approximately 1.90 Gb of high-quality sequence data. The raw data were assembled into 12 contigs exceeding 1000 base pairs, with a sequence coverage of 509X (N50 value = 901,304 and L50 = 2). The assembled genome consists of 3,729,524 base pairs and exhibits a mean GC content of 41.43%. Functional annotation using the RAST server predicted 3,927 coding sequences (CDSs), 59 RNA coding genes, and 3 rRNA genes. The strain ABR harbours a diverse repertoire of Carbohydrate-Active Enzymes (CAZymes), confirming the strain's cellulolytic potential, which has application in lignocellulosic biomass degradation. - Source: PubMed
Publication date: 2026/07/21
Show Binoy KumarLodha TusharGhosh AnudebDhakephalkar PrashantRoss Andrew BChaudhury ShibaniBalachandran Srinivasan