Ask about this productRelated genes to: CD117 antibody
- Gene:
- KIT NIH gene
- Name:
- KIT proto-oncogene, receptor tyrosine kinase
- Previous symbol:
- PBT
- Synonyms:
- CD117, SCFR, C-Kit
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: CD117 antibody
Related articles to: CD117 antibody
- Oligo(para-phenylene ethynylene)s (OPEs) serve as well-defined model compounds to understand electronic effects in conjugated macromolecules. Here, we report a sequence-defined series of OPEs capped with a di-tert-butylcarbazole (DtBCz) donor and a triphenyltriazine (Trz) acceptor to investigate how the donor-acceptor distance along a conjugated OPE backbone governs charge-transfer properties. Using an iterative synthetic strategy, the OPE length was extended stepwise, providing a molecularly highly defined platform to investigate length-dependent excited-state evolution. The lowest excited-state character was examined by steady-state absorption and photoluminescence spectroscopy, Lippert-Mataga analysis, time-resolved photoluminescence (TRPL) spectroscopy, transient absorption (TA) spectroscopy, and quantum-chemical calculations. Shorter OPE sequences (PE0 and PE1) exhibit stronger charge-transfer (CT) dominant behavior, reflected by clear donor-acceptor coherence in transition-density analyses and pronounced solvatochromism. With increasing OPE length (PE2 and PE3), locally excited (LE) contributions become more prominent, leading to hybridized LE and CT (HLCT) states which is further supported by TA and TRPL spectroscopy. The observed CT-to-HLCT evolution highlights the importance of precise backbone length control for rationally tuning excited-state properties in conjugated macromolecules. - Source: PubMed
Publication date: 2026/09/23
Cai QianyuPaha TillArmbruster MarianneJung AndréZysman-Colman EliUnterreiner Andreas-NeilMeier Michael A R - Hepatitis B virus (HBV) infection remains a major public health challenge in sub-Saharan Africa, including Ghana, despite the infant vaccination programs. Limited data exist on HBV prevalence and predictors in informal sector populations, who may face unique occupational and behavioral exposures. This study assessed the prevalence and predictors of HBV infection among sellers and workers at Kejetia Market, Ghana's largest commercial hub. - Source: PubMed
Boateng De-Graft Kwaku OfosuObeng Michael AgyemangAttah Joshua KofiShardow Abdul Latif KoneyBoateng Clinton OwusuOkwan Daniel KobinaAhadzie Senam Yawa NunameyTakyi PiusScott Godfred YawsonAbrampah Akwasi AmponsahBoakye Felix KusiOduro PatrickNouwati Daniel DzemedoAmankwah Kofi BonsuHassanin Reem MahmoudAdams Mohammed MahiRahamani Abu Abudu - Blue light is becoming increasingly prevalent in our daily lives. However, the possible deleterious effects of blue light exposure on the skin have been largely overlooked. We have previously shown that blue light has the ability to induce mitochondrial DNA (mtDNA) damage and dysfunction in human dermal fibroblasts (HDFn). However, whether blue light is able to induce senescence in skin has yet to be investigated. Cellular senescence is a key part of the aging process and is heavily associated with an aging phenotype. Our study involved exposing HDFn to varying doses of blue light before assessing the expression of known senescence markers using both immunofluorescence and gene expression qPCR. We also assessed beta-galactosidase activity using a senescence-associated beta-galactosidase (SA β-gal) staining kit. Blue light induces increased γH2AX expression ( = ≤ 0.0001), indicating its ability to induce DNA double-strand breaks. P21, a known marker of senescence, is increased in response to blue light, as seen in both immunofluorescence and gene expression, where a 15-fold increase is reported in cells exposed to 50 J/cm blue light ( = ≤ 0.001). Importantly, NFκB also displayed a dose-dependent increase in expression following blue light exposure, with 25 J/cm ( = ≤ 0.0001) and 50 J/cm ( = ≤ 0.0001) inducing maximal nuclear translocation. SA β-gal activity also increased in response to blue light, with 25 J/cm being the minimum dose required to induce statistical significance ( = ≤ 0.01) when compared to a non-irradiated control group. Taken together, we demonstrate that blue light may have the ability to induce not only mtDNA damage but also nuclear DNA (nDNA) damage. This, combined with the increased expression of senescent markers and SA-β-gal activity, suggests that blue light could induce cellular senescence while also eliciting the bystander effect in neighboring cells due to increased NFκB nuclear translocation and associated reactive oxygen species (ROS) production. These findings emphasize the need for further research into the potential deleterious effects of senescence in skin and for future interventions to attenuate these effects. - Source: PubMed
Publication date: 2026/09/22
McNish HelenMathapathi Mruthyunjaya SwamyFiglak KatarzynaDamodaran AnitaBirch-Machin Mark - Very rarely, live attenuated varicella zoster virus (VZV) vaccine recipients develop herpes zoster (HZ) without a preceding history of clinical varicella. A 14-month-old girl without prior varicella developed vesicles on her right arm and back. She received zoster vaccine live (ZVL) on the right arm 65 days earlier. A rapid immunochromatographic VZV antigen detection kit (DermaQuick VZV, Maruho, Osaka, Japan) was positive. Because PCR strain typing was not performed, the causative agent could not be definitively identified as the vaccine strain; therefore, breakthrough varicella or HZ due to wild-type VZV could not be completely ruled out. Based on the clinical and laboratory findings, she was diagnosed with HZ. Weight-adjusted oral valacyclovir was initiated at 200 mg four times daily for seven days. At seven-day follow-up, the vesicles had resolved into erythema and erythematous papules accompanied by desquamation in some areas. Assuming the HZ in our current case originated from the ZVL strain, it is hypothesized that the administered virus replicated locally in the skin, traveled retrogradely via sensory nerves to establish latency, and subsequently reactivated to cause HZ in the dermatome that corresponded to the injection site. Clinicians should include HZ in the differential diagnosis when they encounter a unilateral vesicular eruption in an immunocompetent infant with no history of varicella. DermaQuick, a simple and minimally invasive method, is extremely useful for rapidly diagnosing such cases. - Source: PubMed
Publication date: 2026/09/08
Omi MichiyaWatanabe DaisukeTakeichi Takuya - Hepatitis E virus (HEV) infection is emerging but under-recognized worldwide. However, the epidemiology and ecology of this infection in Chile are poorly understood. This study aimed to detect and analyze hepatitis E seroprevalence among blood donors at a private health care center in Santiago, Chile. - Source: PubMed
Publication date: 2026/08/22
Porte LorenaWeitzel Ian BatistaMartínez-Valdebenito CostanzaPizarro GabrielBustamante VerónicaWeitzel Thomas