Ask about this productRelated genes to: CD106 antibody
- Gene:
- VCAM1 NIH gene
- Name:
- vascular cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- CD106
- Chromosome:
- 1p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2016-10-05
Related products to: CD106 antibody
Related articles to: CD106 antibody
- A simple and convenient approach involving visible-light-induced, TBHP-mediated oxidation of propargyl alcohols to ynone in aqueous media has been developed. This photoinduced protocol was conducted under an aerobic-aqueous medium using Eosin Y as a photosensitizer. A diverse range of ynone derivatives were prepared from propargyl alcohol in moderate to excellent yield. Furthermore, the successful gram-scale experiment of this method also indicates its flexibility and applicability for industrial applications. Steric mapping of the series 2a-2q, exemplified by 2j, revealed an optimized buried volume and three-dimensional bulk distribution that closely mimics the reference PKC inhibitor while surpassing the less efficient steric profiles of the MSY and VCAM1 analogues. In addition, an exit vector analysis was carried out to get a clearer insight into the substituent orientation and spatial vector divergence. - Source: PubMed
Bera BimanHalder ArabindaKumar PradeepVasudev Prema GSaid Musa ABera Mrinal K - The endothelium maintains vascular health by regulating blood flow and protecting against inflammatory damage. In type 2 diabetes (T2DM), however, hyperglycemia, hypertension, and hyperlipidemia place a significant burden on the endothelium, potentially leading to atherosclerosis and cardiovascular disease (CVD). While semaglutide and empagliflozin have been shown to reduce CVD risk in T2DM, it remains unclear whether these benefits are mediated by improved endothelial function. This post-hoc analysis explores the effects of these agents on markers of endothelial function, i.e. the reactive hyperaemic index (RHI) and the endothelial-derived cell adhesion molecules (CAMs) E-Selectin, ICAM-1, P-Selectin, and VCAM-1. - Source: PubMed
Publication date: 2026/08/29
Gullaksen SørenVernstrøm LivSørensen Steffen SkovgaardFunck Kristian LøkkePoulsen Per LøgstrupLaugesen Esben - The upregulation of vascular cell adhesion molecule-1 (VCAM-1) by the transcription factor GATA-6 during inflammation of the brain is a key contributor to neuronal injury. Silencing GATA-6 expression in brain endothelial cells may provide an avenue for ameliorating blood-brain barrier (BBB) inflammation and slowing neurodegeneration. Cationic bicelles composed of DPPC/DCPC/DOTAP at a molar ratio of 63.8/25.0/11.2 were designed for the targeted delivery of GATA-6 siRNA to the BBB. However, formulation processes such as sonication or lyophilization introduce stresses that may impact the structural stability of the bicelles and therapeutic efficacy of the siRNA cargo. Therefore, these processes must be optimized. A sonication time of 3 min was sufficient for achieving a narrow particle size distribution without mechanically damaging the siRNA. A trehalose concentration of 10% w/v was effective at protecting the siRNA-bicelle complexes from particle aggregation and loss of silencing efficiency after 3 cycles of freeze-thaw. By contrast, a sucrose concentration of 5% w/v was only able to protect the siRNA-bicelle complexes from particle aggregation. Moreover, the addition of sucrose partially hindered the cellular uptake of cationic bicelles in polarized human cerebral microvascular endothelial cell (hCMEC/D3) monolayers, suggesting that it is an inappropriate cryoprotectant for cationic bicelles. Optimization of these formulation parameters for siRNA-bicelle complexes contributes towards their efficacy during delivery and stability during storage, which are critical factors to consider in a clinical setting. Thus, these findings will aid in the translation of siRNA-loaded cationic bicelles from the bench to the bedside. - Source: PubMed
Publication date: 2026/08/30
Cheng JoanSalian Vrishali SudeshBadola MuskanKandimalla Karunya K - Long noncoding RNAs (lncRNAs) are key regulators of vascular endothelial function. The lncRNA differentiation antagonizing non-protein coding RNA (DANCR) is implicated in cell proliferation and inflammatory responses; however, its specific role in atherosclerosis remains undefined. - Source: PubMed
Publication date: 2026/08/29
Wang ShutingZhang QiyueLi RongxiaWang YixiaoKamili AdalaitiHan YuqingHou ZhihuiChen YuYang ShujunZhang Weili - Zaoshi Huatan Xiefei Formula (ZHXF) is a Chinese medicine prescription used in the treatment of severe pneumonia (SP). Although clinical studies have confirmed its efficacy in improving pneumonia, the specific bioactive components and their intricate regulatory pathwaysremain incompletely understood. - Source: PubMed
Publication date: 2026/08/22
Shan BaixiZhao ShuaijunZhang ZhijingCao HaiyangJiang YuhangDu YanZhang QinZhao PengLi Jiansheng