Ask about this productRelated genes to: CD106 antibody
- Gene:
- VCAM1 NIH gene
- Name:
- vascular cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- CD106
- Chromosome:
- 1p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2016-10-05
Related products to: CD106 antibody
Related articles to: CD106 antibody
- Deoxynivalenol (DON), a mycotoxin commonly found in grains and feed, poses a serious threat to animal and public health. This study aimed to investigate the underlying mechanisms of DON-induced liver damage in piglets and to elucidate the potential of alginate-encapsulated enzyme in mitigating hepatotoxicity in vivo. - Source: PubMed
Publication date: 2026/09/05
He WeiHuo XiangyuWen XiaoluCao ShutingJiang ZongyongShi BaomingWang Li - Rheumatic fever is an immunologically mediated inflammatory disease that develops following group A streptococcal infection and triggers valvular inflammation that can progress to chronic rheumatic heart disease (RHD), a major cause of cardiovascular morbidity and mortality in low-resource countries. Early diagnosis remains critical for preventing irreversible valvular damage. Elevated levels of circulating endothelial cell adhesion molecules (CAM), particularly E-selectin; ICAM-1; and VCAM-1 have been associated with disease severity, highlighting their potential as diagnostic biomarkers. Here, we report on the development of a polymeric fluorescent probe based on N-(2-hydroxypropyl)methacrylamide (HPMA) for the sensitive detection of serum E-selectin and VCAM-1. The probe incorporates a high-affinity CAM-binding peptide (Esbp or Vbp), fluorescent reporters (FITC or IR783), and a hexa-histidine (His6)-tag to enable plate surface immobilization. Polymers were synthesized with increasing IR783 molar content to induce fluorescence quenching at high dye loadings while preserving activation upon interaction with serum biomarkers. Their sensing performance was evaluated in both buffer and serum using fluorescence-based assays. Surface-immobilized probes demonstrated dose-dependent detection of labeled E-selectin and VCAM-1 in the microgram scale (1-10 µg/ml) in PBS. In serum, the probe exhibited specific and quantitative binding to E-selectin, while VCAM-1 binding was reduced, likely due to interference from abundant serum proteins. Optimization of IR783 content in the polymer revealed that 2.5 mol % dye loading enabled effective fluorescence activation upon interaction with E-selectin, whereas higher dye loadings led to self-quenching and reduced responsiveness, due to IR783-driven self-assembly that hindered signal activation at the tested biomarker concentrations. The optimized probe successfully detected E-selectin in spiked serum samples. This study demonstrates a simple, modular HPMA-based sensing platform for detecting circulating CAM that can be readily adapted to a broad range of serum biomarkers. By utilizing polymer-based probes that are inherently more stable and lower in cost than antibody-based reagents, the platform addresses key limitations of current diagnostics and offers a promising route toward affordable, rapid assays for RHD in low-resource settings. Further optimization may enhance sensitivity and expand biomarker coverage to improve clinical applicability. - Source: PubMed
Publication date: 2026/09/04
Teboul IlanaShlush NaamaDroby MayaVentura YvonneLevine Robert ADavid Ayelet - Plaque heterogeneity underlies the propensity of atherosclerotic lesions to rupture and trigger cardiovascular events. Most proteomic studies examine bulk changes, obscuring key spatial differences in protein abundance. We report a high-resolution spatial proteomics workflow exploring the molecular landscape of human plaques and a murine myocardium. By combining laser capture microdissection with high-sensitivity ion-mobility mass spectrometry, spatial profiling of cellular and extracellular matrix (ECM) proteomes was achieved. Over 2700 proteins were detected from 50,000 μm2 areas, revealing substantial intraplaque heterogeneity across distinct regions (lipid-rich, media, shoulder, necrotic core, intima) and distance from the artery lumen. Inverse correlations between proteases (cathepsin B) and core structural ECM proteins (perlecan, HSPG2) indicated active ECM remodeling. Analysis of media layers indicated distinct protein signatures associated with smooth muscle contraction and cell-cell communication. Blood coagulation signatures, including platelet degranulation and fibrin formation, were enriched at the intima. Inflammatory (clusters of differentiation 4/68, CD4/CD68; vascular cell adhesion molecule 1, VCAM1) and vascular damage markers (tenascin-C, TNC) were enriched in shoulder regions. The necrotic core was dominated by blood proteins, consistent with intraplaque hemorrhage. This workflow resolves proteomic changes over ∼200 μm distances, providing unprecedented insights into plaque morphology and offers a powerful tool for elucidating plaque biology. - Source: PubMed
Jokumsen Kathrine VLorentzen Lasse GYeung KarinResch Timothy AEiberg Jonas PDavies Michael JGamon Luke F - Long COVID, a major post-acute infection syndrome (PAIS), characterized by prolonged or new-onset symptoms following acute COVID-19, critically affects patients' quality of life. Establishing easily measurable and objective biomarkers that reflect disease severity is essential for clinical management. This retrospective cohort study evaluated serum levels of growth differentiation factor 15 (GDF-15), a mitochondrial stress marker, and vascular cell adhesion molecule-1 (VCAM-1), a vascular endothelial stress marker, in 32 patients with Long COVID who presented with persistent systemic or neurological symptoms and had not required acute-phase hospitalization. Serum GDF-15, VCAM-1, and inflammatory cytokine levels were measured at the initial visit and at 3 and 6 months. Differences between patients who recovered at 6 months and those who did not (non-improved group) were analyzed using linear mixed-effects models (LMMs). Most inflammatory cytokines remained near their lower detection limits and were excluded from the longitudinal analysis. The LMMs revealed sustained elevation of both GDF-15 ( = 0.02) and VCAM-1 ( = 0.03) levels in the non-improved group. These findings suggest that longitudinal tracking of these two markers may offer clinically relevant insights into disease activity and treatment-resistant pathophysiology in mild acute-phase Long COVID. - Source: PubMed
Publication date: 2026/08/20
Ono RieTakayama ShinAbe MichiakiArita RyutaroOnodera KohIshizawa KotaKanno TakeshiSaito NatsumiKikuchi AkikoAbe TakaakiIshii Tadashi - Extramedullary hematopoiesis is increasingly recognized as an important mechanism by which peripheral tissues augment immune responses during inflammation and infection. However, the mechanisms governing recruitment, retention, and local differentiation of circulating hematopoietic stem and progenitor cells (HSPCs) within human tissues remain poorly understood due to the lack of physiologically relevant experimental models. Here, we developed a human skin-on-a-chip microphysiological platform to investigate the role of circulating hematopoietic stem and progenitor cells (HSPCs) in cutaneous immune responses and their potential contribution to extramedullary hematopoiesis. The device recapitulates key features of human skin, including a perfusable vascular endothelium, fibroblast-populated dermis, and keratinocyte epidermis. Upon stimulation with pro-inflammatory cytokines or a TLR2 agonist, endothelial activation significantly increased ICAM-1 and VCAM-1 expression and enhanced recruitment of both neutrophils (PMNs) and HSPCs. While PMNs readily underwent transendothelial migration into the dermal compartment, HSPCs remained localized to the vascular niche. Notably, HSPCs adhered robustly and persisted on inflamed endothelium independent of SDF-1/CXCR4 signaling. Under granulopoietic conditions, these retained HSPCs differentiated locally within the vascular compartment into PMN-like cells capable of phagocytosis and exhibiting pathogen-responsive gene expression profiles. These findings provide evidence in a human model that circulating HSPCs can contribute to host defense localized granulopoiesis without tissue infiltration, and suggests that the vascular niche itself may serve as a site of immune cell production during infection. The platform further offers a foundation for developing HSPC-based therapeutic strategies to combat antibiotic-resistant skin infections. - Source: PubMed
Publication date: 2026/09/03
Cirves Evan PWallace Stormy KChiaramonte Bella SJudy MadisonShirure Venktesh SShergill Bhupinder SGeorge Steven C