Ask about this productRelated genes to: CD105 antibody
- Gene:
- ENG NIH gene
- Name:
- endoglin
- Previous symbol:
- ORW1, ORW
- Synonyms:
- END, HHT1, CD105
- Chromosome:
- 9q34.11
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-03
- Date modifiied:
- 2019-04-23
Related products to: CD105 antibody
Related articles to: CD105 antibody
- Early detection of right ventricular (RV) dysfunction is essential in pulmonary arterial hypertension (PAH) but remains challenging using conventional echocardiography. This study investigates the feasibility of a noninvasive, physics-based framework using three-dimensional (3D) echocardiography that integrates myocardial strain and volumetric flow analysis to characterize RV mechanical performance across stages of PAH. - Source: PubMed
Publication date: 2026/05/01
Hashemi Mohammad SaberFalahatpisheh AhmadFarsiani YasamanMatusov YuriSingh SiddharthGhafourian KambizPedrizzetti GianniKheradvar Arash - Meniscal allograft transplantation can restore joint biomechanics and alleviate symptoms, but its clinical use is limited by the scarcity of size-matched, structurally intact grafts. Current two-dimensional sizing and subjective inspection in tissue banks fail to capture complex three-dimensional geometry and subtle surface defects, highlighting the need for an accurate, reliable, and practical solution for routine donor tissue evaluation. - Source: PubMed
Publication date: 2026/05/01
Sun ShuchunPan GeZhao JichaoPullen William MichaelChen JianMa HaiyangBridges William CMueller DustinYao HaiWang Shangping - Meniscal injuries are one of the most frequent orthopedic injuries and often lead to joint degeneration and osteoarthritis if left untreated. Current meniscus prostheses are limited by inadequate mechanical properties and poor integration with native tissue, leading to high failure rates and limited long-term success. The field of meniscus replacement aims to develop scaffolds that mimic the native meniscus's complex structure and mechanical properties while promoting tissue regeneration and integration (when targeting a tissue-engineered meniscus). However, traditional fabrication methods, such as fused deposition modeling (FDM) 3D printing, are limited by the narrow range of compatible materials and insufficient resolution for producing highly porous and biocompatible scaffolds. To overcome these challenges, this study introduces a novel injection molding setup designed to fabricate scaffolds using hydrogel building blocks, AUP4K DA and AUP4K HA, specifically engineered for meniscus replacement applications. The scaffolds were characterized to assess their suitability for meniscus replacement. Microscopic analysis and SEM analysis revealed an interconnected porous network with uniform pore distribution and the absence of traces of the applied negative mold used to fabricate the scaffold. Swelling degree and gel fraction were evaluated to confirm the high hydrogels' water retention and cross-linking efficiency, respectively. Mechanical properties were analyzed through compression testing and texture profile analysis (TPA), demonstrating that the scaffolds exhibit compressive strength and viscoelastic behavior in the range of native human meniscal tissue. By addressing the material and structural limitations of FDM printing, the injection molding setup presents a versatile platform for fabricating hydrogel-based scaffolds with a large range of mechanical properties. This study thus provides a promising solution for meniscus replacement, paving the way for the development of hydrogel scaffolds that mimic the native meniscal tissue. - Source: PubMed
Publication date: 2026/05/01
Meazzo MartinaRamezani AlìBarberis FabrizioVan Der Straeten CatherineDubruel Peter - Viscoelastic biomaterials that exhibit biomimetic responses to applied stresses are important in studying physiology and designing biomaterial scaffolds. Particle-based hydrogels offer potential for engineering viscoelasticity through the design of both the component microparticles and their processing into bulk particle-based materials. When particles are not cross-linked to one another, particle movements in response to strain can potentially relieve applied stresses and facilitate the material's use in dynamic processes like bioprinting. In particle-based hydrogels based on spherical hydrogel microparticles (HMPs), particle movement is restricted by contact with immediately adjacent HMPs. In comparison, fiber-based hydrogel systems leverage high-aspect-ratio microfiber components with long-range interactions. Here, microfibers with aspect ratios of ∼15:1 length/diameter are used to form particle-based hydrogels to compare how interparticle interactions at increased length scales alter properties compared to particle-based hydrogels based on spherical HMPs. Like particle-based hydrogels formed from spherical HMPs, those formed from fiber HMPs exhibit viscoelasticity with shear-thinning and self-healing behaviors. But fiber-based materials allow enhanced control over bulk stress relaxation times ( ∼ 1-100+ s) across a range of applied strains (σ ∼ 2.5%-50%) in a packing density-dependent fashion. Fiber-based systems relaxed stresses continuously and to a greater degree at low strains in comparison to HMP systems. Dynamic interfiber interactions in fiber-based hydrogels also supported embedded printing, where perfusable channels can be printed into fiber-based hydrogels stabilized by physical interfiber interactions. Taken together, fiber-based hydrogels offer opportunities for designing complex biomaterial scaffolds, including allowing control over viscoelastic properties through hydrogel design and control over heterogeneous 3D structures through embedded printing. - Source: PubMed
Publication date: 2026/05/01
Grewal M GregoryFerrarese EmilyPorter LaurenHelein Georgia THighley Christopher B - Aortic valve (AV) disease is a major contributor to cardiovascular morbidity, particularly in ageing populations. Although surgical and transcatheter AV replacement are established treatments, no current prosthesis fully reproduces the haemodynamic performance and durability of the native AV without clinical compromise. This review examines prosthetic heart valves in the aortic position from an engineering perspective, with emphasis on mechanical heart valves (MHVs) and bileaflet mechanical heart valves (BMHVs). The pathophysiology of aortic stenosis and aortic regurgitation is briefly outlined to contextualise replacement strategies, followed by a critical evaluation of bioprosthetic, mechanical, polymeric, homograft, autograft, and transcatheter valve technologies. The evolution of MHVs is reviewed alongside key considerations in material selection, including titanium alloys and pyrolytic carbon, and their associated mechanical and haemocompatibility properties. Fundamental fluid dynamic principles governing transvalvular flow, shear stress, and thrombogenicity are discussed in relation to valve geometry and hinge design. Anticoagulation requirements and their clinical implications are examined within the context of blood-material interactions. Despite significant advancements, contemporary BMHVs remain limited by non-physiological flow patterns and the lifelong need for anticoagulation therapy. Future development should prioritise improved leaflet kinematics, optimised hinge mechanics, and enhanced haemocompatibility to better approximate native valve function while reducing thromboembolic risk. - Source: PubMed
Publication date: 2026/05/01
Goode DylanDhaliwal RubyMohammadi DahliaMohammadi Hadi